Prediction of methionine oxidation risk in monoclonal antibodies using a machine learning method

Evaluation of Transdermal Drug Permeation as Modulated by Lipoderm and Pluronic Lecithin Organogel

(2018) Qian Zhang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Comparisons of Protein Dynamics from Experimental Structure Ensembles, Molecular Dynamics Ensembles, and Coarse-Grained Elastic Network Models

(2018) Kannan Sankar et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure Based Prediction of Asparagine Deamidation Propensity in Monoclonal Antibodies

(2018) Qingrong Yan et al.   mAbs

Rapid assessment of oxidation via middle-down LCMS correlates with methionine side-chain solvent-accessible surface area for 121 clinical stage monoclonal antibodies

(2017) Rong Yang et al.   mAbs

In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions

(2017) Dheeraj S. Tomar et al.   mAbs

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered dynamics upon oligomerization corresponds to key functional sites

(2017) Sambit Kumar Mishra et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Current progress in innovative engineered antibodies

(2017) William R. Strohl   Protein & Cell

Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions

(2017) Francisco J. Veredas et al.   Scientific Reports

Therapeutic monoclonal antibodies for respiratory diseases: Current challenges and perspectives, March 31 – April 1, 2016, Tours, France

(2016) Guillaume Desoubeaux et al.   mAbs

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(2016)   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Modeling the Oxidation of Methionine Residues by Peroxides in Proteins

(2015) Naresh Chennamsetty et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Golden Retriever Lifetime Study: establishing an observational cohort study with translational relevance for human health

(2015) Michael K. Guy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions

(2014) Jasmin F. Sydow et al.   PLoS One

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessment of fully automated antibody homology modeling protocols in molecular operating environment

(2014) Johannes K. X. Maier et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Second antibody modeling assessment (AMA-II)

(2014) Juan C. Almagro et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Methionine-aromatic Motif Plays a Unique Role in Stabilizing Protein Structure

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predicting protein oxidation sites with feature selection and analysis approach

(2012) Shen Niu et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Antibody Repertoires in Humanized NOD-scid-IL2Rγnull Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse

(2012) Gregory C. Ippolito et al.   PLoS One

Structural Consensus among Antibodies Defines the Antigen Binding Site

(2012) Vered Kunik et al.   PLoS Computational Biology

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

(2011) Amy C. King et al.   PROTEIN SCIENCE

Antibody modeling assessment

(2011) Juan C. Almagro et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Global Dynamics of Proteins: Bridging Between Structure and Function

(2010) Ivet Bahar et al.   Annual Review of Biophysics

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Predictive tools for stabilization of therapeutic proteins

(2010) Vladimir Voynov et al.   mAbs

Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization

(2009) Junyan A. Ji et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

(2008) Dingjiang Liu et al.   BIOCHEMISTRY

Considerations for the development of therapeutic monoclonal antibodies

(2008) Patrick G Swann et al.   CURRENT OPINION IN IMMUNOLOGY

IMGT(R), the international ImMunoGeneTics information system(R)

(2008) M.-P. Lefranc et al.   NUCLEIC ACIDS RESEARCH