Chromatin modifiers and the promise of epigenetic therapy in acute leukemia
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Title
Chromatin modifiers and the promise of epigenetic therapy in acute leukemia
Authors
Keywords
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Journal
LEUKEMIA
Volume 28, Issue 7, Pages 1396-1406
Publisher
Springer Nature
Online
2014-03-10
DOI
10.1038/leu.2014.94
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Note: Only part of the references are listed.- An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
- (2013) Kyle D. Konze et al. ACS Chemical Biology
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations
- (2013) M. Neumann et al. BLOOD
- A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
- (2013) S. J. Kim et al. BLOOD
- Genomic impact of transient low-dose decitabine treatment on primary AML cells
- (2013) J. M. Klco et al. BLOOD
- Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML
- (2013) A. Chaturvedi et al. BLOOD
- PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains
- (2013) S. Picaud et al. CANCER RESEARCH
- The molecular profile of adult T-cell acute lymphoblastic leukemia: Mutations inRUNX1andDNMT3Aare associated with poor prognosis in T-ALL
- (2013) Vera Grossmann et al. GENES CHROMOSOMES & CANCER
- The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBP and differentiation in MLL-AF9 leukemia
- (2013) A. T. Thiel et al. HAEMATOLOGICA
- Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
- (2013) S. A. Mian et al. HAEMATOLOGICA
- Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen
- (2013) Joyce Sayegh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia
- (2013) Maria E. Figueroa et al. JOURNAL OF CLINICAL INVESTIGATION
- Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group
- (2013) Maxime Janin et al. JOURNAL OF CLINICAL ONCOLOGY
- NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
- (2013) J D E de Rooij et al. LEUKEMIA
- Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)
- (2013) H Méreau et al. LEUKEMIA
- Targeted disruption of the EZH2–EED complex inhibits EZH2-dependent cancer
- (2013) Woojin Kim et al. Nature Chemical Biology
- Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells
- (2013) Xiao-ning Gao et al. PLoS One
- An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells
- (2013) D. Rohle et al. SCIENCE
- Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation
- (2013) F. Wang et al. SCIENCE
- PRMT4 Blocks Myeloid Differentiation by Assembling a Methyl-RUNX1-Dependent Repressor Complex
- (2013) Ly P. Vu et al. Cell Reports
- Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies
- (2012) L. I. Kroeze et al. BLOOD
- Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
- (2012) S. Tanaka et al. BLOOD
- Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
- (2012) A. Shi et al. BLOOD
- PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential
- (2012) W.-J. Shia et al. BLOOD
- BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
- (2012) C. J. Ott et al. BLOOD
- The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
- (2012) William J. Harris et al. CANCER CELL
- An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia
- (2012) Tanja A. Gruber et al. CANCER CELL
- Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells
- (2012) Hsing-Chen Tsai et al. CANCER CELL
- ASXL1 Mutations Promote Myeloid Transformation through Loss of PRC2-Mediated Gene Repression
- (2012) Omar Abdel-Wahab et al. CANCER CELL
- The Origin and Evolution of Mutations in Acute Myeloid Leukemia
- (2012) John S. Welch et al. CELL
- Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
- (2012) J. J. Trowbridge et al. GENES & DEVELOPMENT
- Age-Related Prognostic Impact of Different Types ofDNMT3AMutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia
- (2012) Guido Marcucci et al. JOURNAL OF CLINICAL ONCOLOGY
- Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemia
- (2012) B G Mar et al. LEUKEMIA
- CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia
- (2012) A Inthal et al. LEUKEMIA
- DNA Methylation Dynamics during In Vivo Differentiation of Blood and Skin Stem Cells
- (2012) Christoph Bock et al. MOLECULAR CELL
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
- (2012) Laurens Kruidenier et al. NATURE
- EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
- (2012) Michael T. McCabe et al. NATURE
- IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
- (2012) Masato Sasaki et al. NATURE
- The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
- (2012) Jinghui Zhang et al. NATURE
- Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
- (2012) Jolanta Grembecka et al. Nature Chemical Biology
- Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
- (2012) Lambert Busque et al. NATURE GENETICS
- Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
- (2012) Panagiotis Ntziachristos et al. NATURE MEDICINE
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia
- (2012) Jay P. Patel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Polycomb repressive complex 2 is required for MLL-AF9 leukemia
- (2012) T. Neff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine
- (2012) J. A. Hackett et al. SCIENCE
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
- (2011) Ana Puda et al. AMERICAN JOURNAL OF HEMATOLOGY
- Structural basis for CARM1 inhibition by indole and pyrazole inhibitors
- (2011) John S. Sack et al. BIOCHEMICAL JOURNAL
- Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
- (2011) A. M. Jankowska et al. BLOOD
- Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks
- (2011) S. Deneberg et al. BLOOD
- The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
- (2011) C. L. Green et al. BLOOD
- Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
- (2011) S. Y. Jo et al. BLOOD
- DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
- (2011) A. T. Nguyen et al. BLOOD
- Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
- (2011) Z. Li et al. BLOOD
- KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
- (2011) J. He et al. BLOOD
- TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
- (2011) W.-C. Chou et al. BLOOD
- NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
- (2011) I. H. I. M. Hollink et al. BLOOD
- TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
- (2011) Cyril Quivoron et al. CANCER CELL
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
- (2011) Kathrin M. Bernt et al. CANCER CELL
- CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis
- (2011) Jiaying Tan et al. CANCER CELL
- JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
- (2011) Fan Liu et al. CANCER CELL
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
- (2011) Kelly Moran-Crusio et al. CANCER CELL
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells
- (2011) Lan-Lan Smith et al. Cell Stem Cell
- Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
- (2011) H. Wu et al. GENES & DEVELOPMENT
- Phase I Study of Oral Azacitidine in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia
- (2011) Guillermo Garcia-Manero et al. JOURNAL OF CLINICAL ONCOLOGY
- Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia
- (2011) Felicitas Thol et al. JOURNAL OF CLINICAL ONCOLOGY
- TET2Mutations Improve the New European LeukemiaNet Risk Classification of Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
- (2011) Klaus H. Metzeler et al. JOURNAL OF CLINICAL ONCOLOGY
- Small-Molecule Ligands of Methyl-Lysine Binding Proteins
- (2011) J. Martin Herold et al. JOURNAL OF MEDICINAL CHEMISTRY
- Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
- (2011) V Grossmann et al. LEUKEMIA
- CpG methylation patterns and decitabine treatment response in acute myeloid leukemia cells and normal hematopoietic precursors
- (2011) S Negrotto et al. LEUKEMIA
- ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy
- (2011) D Bhojwani et al. LEUKEMIA
- Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
- (2011) O Abdel-Wahab et al. LEUKEMIA
- Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells
- (2011) J Yuan et al. LEUKEMIA
- CREBBP mutations in relapsed acute lymphoblastic leukaemia
- (2011) Charles G. Mullighan et al. NATURE
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- (2011) Johannes Zuber et al. NATURE
- Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
- (2011) Mark A. Dawson et al. NATURE
- Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
- (2011) William A. Pastor et al. NATURE
- A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
- (2011) Masoud Vedadi et al. Nature Chemical Biology
- Analysis of the coding genome of diffuse large B-cell lymphoma
- (2011) Laura Pasqualucci et al. NATURE GENETICS
- Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia
- (2011) Víctor Quesada et al. NATURE GENETICS
- Dnmt3a is essential for hematopoietic stem cell differentiation
- (2011) Grant A Challen et al. NATURE GENETICS
- Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
- (2011) Xiao-Jing Yan et al. NATURE GENETICS
- SF3B1and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia
- (2011) Lili Wang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring
- (2010) Feng Xu et al. ANNALS OF HEMATOLOGY
- IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
- (2010) S. Schnittger et al. BLOOD
- Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
- (2010) S. Lugthart et al. BLOOD
- Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value
- (2010) S. Abbas et al. BLOOD
- Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
- (2010) Maria E. Figueroa et al. CANCER CELL
- DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia
- (2010) Maria E. Figueroa et al. CANCER CELL
- Jarid2 and PRC2, partners in regulating gene expression
- (2010) G. Li et al. GENES & DEVELOPMENT
- Prognostic Impact of Isocitrate Dehydrogenase Enzyme Isoforms 1 and 2 Mutations in Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group
- (2010) Nicolas Boissel et al. JOURNAL OF CLINICAL ONCOLOGY
- IDH1andIDH2Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
- (2010) Guido Marcucci et al. JOURNAL OF CLINICAL ONCOLOGY
- IDH1 and IDH2 Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia With NPM1 Mutation Without FLT3 Internal Tandem Duplication
- (2010) Peter Paschka et al. JOURNAL OF CLINICAL ONCOLOGY
- Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
- (2010) Stefan Gross et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
- (2010) J Boultwood et al. LEUKEMIA
- Comprehensive methylome map of lineage commitment from haematopoietic progenitors
- (2010) Hong Ji et al. NATURE
- Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
- (2010) Shinsuke Ito et al. NATURE
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
- (2010) Gorica Nikoloski et al. NATURE GENETICS
- Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
- (2010) Ryan D Morin et al. NATURE GENETICS
- Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
- (2010) Thomas Ernst et al. NATURE GENETICS
- DNMT3AMutations in Acute Myeloid Leukemia
- (2010) Timothy J. Ley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
- (2010) W. Blum et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies
- (2009) Honghe Wan et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study
- (2009) B. V. Balgobind et al. BLOOD
- Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
- (2009) T. E. Fandy et al. BLOOD
- The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors
- (2009) F. M. Perez-Campo et al. BLOOD
- Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
- (2009) Jamy C. Peng et al. CELL
- Moz and Retinoic Acid Coordinately Regulate H3K9 Acetylation, Hox Gene Expression, and Segment Identity
- (2009) Anne K. Voss et al. DEVELOPMENTAL CELL
- The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation
- (2009) H. Boukarabila et al. GENES & DEVELOPMENT
- DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes
- (2009) Lanlan Shen et al. JOURNAL OF CLINICAL ONCOLOGY
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
- (2009) Gang G. Wang et al. NATURE
- Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
- (2009) Yingli Sun et al. NATURE CELL BIOLOGY
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
- (2009) Ann-Marie Bröske et al. NATURE GENETICS
- PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
- (2009) Quan Zhao et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mutation inTET2in Myeloid Cancers
- (2009) François Delhommeau et al. NEW ENGLAND JOURNAL OF MEDICINE
- HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells
- (2008) R. Rao et al. BLOOD
- High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated
- (2008) S. Lugthart et al. BLOOD
- Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
- (2008) Y. Jiang et al. BLOOD
- Menin Critically Links MLL Proteins with LEDGF on Cancer-Associated Target Genes
- (2008) Akihiko Yokoyama et al. CANCER CELL
- Prospective Analysis ofTELGene Rearrangements in Childhood Acute Lymphoblastic Leukemia: A Children's Oncology Group Study
- (2008) Jeffrey E. Rubnitz et al. JOURNAL OF CLINICAL ONCOLOGY
- Arginine methylation regulates the p53 response
- (2008) Martin Jansson et al. NATURE CELL BIOLOGY
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