B-lineage transcription factors and cooperating gene lesions required for leukemia development

Advances in the Genetics of High-Risk Childhood B-Progenitor Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia: Implications for Therapy

(2012) M. L. Loh et al.   CLINICAL CANCER RESEARCH

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells

(2012) I. Gyory et al.   GENES & DEVELOPMENT

Essential role of EBF1 in the generation and function of distinct mature B cell types

(2012) Bojan Vilagos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx1–Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1

(2012) Wooseok Seo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biochemical and Phosphoproteomic Analysis of the Helix-Loop-Helix Protein E47

(2012) R. Teachenor et al.   MOLECULAR AND CELLULAR BIOLOGY

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

(2012) Giusy Della Gatta et al.   NATURE MEDICINE

The Origin and Nature of Tightly Clustered BTG1 Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution

(2012) Esmé Waanders et al.   PLoS Genetics

Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation

(2011) Brandy D. Hyndman et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer

(2011) J. A. I. Thoms et al.   BLOOD

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

(2011) A. P. Ng et al.   BLOOD

Overexpression of LEF1 predicts unfavorable outcome in adult patients with B-precursor acute lymphoblastic leukemia

(2011) A. Kuhnl et al.   BLOOD

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

(2011) J. Zhang et al.   BLOOD

PAX5 deletion is common and concurrently occurs with CDKN2A deletion in B-lineage acute lymphoblastic leukemia

(2011) Miyoung Kim et al.   BLOOD CELLS MOLECULES AND DISEASES

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

(2011) Shane McManus et al.   EMBO JOURNAL

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

(2011) S. Taoudi et al.   GENES & DEVELOPMENT

The Distal VH Gene Cluster of the Igh Locus Contains Distinct Regulatory Elements with Pax5 Transcription Factor-Dependent Activity in Pro-B Cells

(2011) Anja Ebert et al.   IMMUNITY

Histone Acetyltransferase p300 Acetylates Pax5 and Strongly Enhances Pax5-mediated Transcriptional Activity

(2011) Ti He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Genomic loss of the putative tumor suppressor geneE2Ain human lymphoma

(2011) Anne Steininger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ebf1orPax5haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia

(2011) Lynn M. Heltemes-Harris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development

(2011) T C Luis et al.   LEUKEMIA

Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation

(2011) Stefania Bottardi et al.   NUCLEIC ACIDS RESEARCH

Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG

(2011) L H Mochmann et al.   ONCOGENE

Dominant-negative mechanism of leukemogenic PAX5 fusions

(2011) N Kawamata et al.   ONCOGENE

The Leukemia-Specific Fusion Gene ETV6/RUNX1 Perturbs Distinct Key Biological Functions Primarily by Gene Repression

(2011) Gerhard Fuka et al.   PLoS One

ERG Deregulation Induces PIM1 Over-Expression and Aneuploidy in Prostate Epithelial Cells

(2011) Vera Magistroni et al.   PLoS One

Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

(2010) A. Gutierrez et al.   BLOOD

LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis

(2010) A. Gutierrez et al.   BLOOD

Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

(2010) R. C. Harvey et al.   BLOOD

hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin

(2010) Min Yang et al.   CANCER BIOLOGY & THERAPY

Ikaros in immune receptor signaling, lymphocyte differentiation, and function

(2010) Matthias Merkenschlager   FEBS LETTERS

Structure of an Ebf1:DNA complex reveals unusual DNA recognition and structural homology with Rel proteins

(2010) N. Treiber et al.   GENES & DEVELOPMENT

Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin

(2010) Thomas Treiber et al.   IMMUNITY

Phosphorylation of RUNX1 by Cyclin-dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3

(2010) Hong Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Determination of Functional Domains in Early B-cell Factor (EBF) Family of Transcription Factors Reveals Similarities to Rel DNA-binding Proteins and a Novel Dimerization Motif

(2010) Marina I. Siponen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes

(2010) Rachit Bakshi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors

(2010) J de Boer et al.   LEUKEMIA

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

(2010) C Virely et al.   LEUKEMIA

Deletions of the transcription factor Ikaros in myeloproliferative neoplasms

(2010) R Jäger et al.   LEUKEMIA

IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL

(2010) R P Kuiper et al.   LEUKEMIA

Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression

(2010) S. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells

(2010) N. K. Wilson et al.   MOLECULAR AND CELLULAR BIOLOGY

A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

(2010) Yin C Lin et al.   NATURE IMMUNOLOGY

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

(2009) A. P. Ng et al.   BLOOD

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

(2009) B. Jacob et al.   BLOOD

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

(2009) L. J. Russell et al.   BLOOD

Runx1 promotes B-cell survival and lymphoma development

(2009) Karen Blyth et al.   BLOOD CELLS MOLECULES AND DISEASES

ERG Is a Megakaryocytic Oncogene

(2009) S. Salek-Ardakani et al.   CANCER RESEARCH

TEL-AML1 Corrupts Hematopoietic Stem Cells to Persist in the Bone Marrow and Initiate Leukemia

(2009) Jeffrey W. Schindler et al.   Cell Stem Cell

Ikaros controls isotype selection during immunoglobulin class switch recombination

(2009) MacLean Sellars et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

(2009) J Familiades et al.   LEUKEMIA

Germline genomic variants associated with childhood acute lymphoblastic leukemia

(2009) Lisa R Treviño et al.   NATURE GENETICS

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia

(2009) Elli Papaemmanuil et al.   NATURE GENETICS

Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia

(2009) Charles G. Mullighan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage

(2009) M. A. Thal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5

(2009) H. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic inactivation of secreted Frizzled-related proteins in acute myeloid leukaemia

(2008) E. Jost et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

(2008) Babacar Cisse et al.   CELL

β-catenin is involved in N-cadherin–dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1–positive B acute lymphoblastic leukemia cells

(2008) Marit Kveine Nygren et al.   EXPERIMENTAL HEMATOLOGY

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

(2008) X. Zhao et al.   GENES & DEVELOPMENT

A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis

(2008) Konstantin Petropoulos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

(2008) Charles G. Mullighan et al.   NATURE

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

(2008) Stephen J Loughran et al.   NATURE IMMUNOLOGY

Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5

(2008) Jagan M R Pongubala et al.   NATURE IMMUNOLOGY

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE