SIAH proteins: critical roles in leukemogenesis

The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities

(2015)   Oncotarget

PAFc, a Key Player in MLL-rearranged Leukemogenesis

(2015)   Oncotarget

Targeting Taspase1 for Cancer Therapy--Letter

(2012) R. H. Stauber et al.   CANCER RESEARCH

Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells

(2012) Annette Romanski et al.   CELL CYCLE

Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo

(2012) Carolin Bier et al.   FASEB JOURNAL

The Ubiquitin Ligase Siah1 Controls ELL2 Stability and Formation of Super Elongation Complexes to Modulate Gene Transcription

(2012) Min Liu et al.   MOLECULAR CELL

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

(2012) Catherine C. Smith et al.   NATURE

Role of Misfolded N-CoR Mediated Transcriptional Deregulation of Flt3 in Acute Monocytic Leukemia (AML)-M5 Subtype

(2012) Dawn Sijin Nin et al.   PLoS One

Chronic Myeloid Leukemia: Clinical Impact of BCR-ABL1 Mutations and Other Lesions Associated With Disease Progression

(2012) Thomas Ernst et al.   SEMINARS IN ONCOLOGY

The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML

(2012) V Novotny-Diermayr et al.   Blood Cancer Journal

MicroRNA29a regulates the expression of the nuclear oncogene Ski

(2011) S. Teichler et al.   BLOOD

Enforced expression of MLL-AF4 fusion in cord blood CD34+ cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia

(2011) R. Montes et al.   BLOOD

Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment

(2011) E. Goto et al.   BLOOD

Genome-wide functions of PML–RARα in acute promyelocytic leukaemia

(2011) S Saeed et al.   BRITISH JOURNAL OF CANCER

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

(2011) Scott R. Daigle et al.   CANCER CELL

Siah1/SIP regulates p27kip1stability and cell migration under metabolic stress

(2011) Yoshito Nagano et al.   CELL CYCLE

HDAC Inhibitors Potentiate the Activity of the BCR/ABL Kinase Inhibitor KW-2449 in Imatinib-Sensitive or -Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo

(2011) T. Nguyen et al.   CLINICAL CANCER RESEARCH

Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells

(2011) Ulf H Beier et al.   CURRENT OPINION IN IMMUNOLOGY

The super elongation complex (SEC) and MLL in development and disease

(2011) E. Smith et al.   GENES & DEVELOPMENT

Differential regulation of PML–RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1

(2011) Kristin Pietschmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

USP13 Enzyme Regulates Siah2 Ligase Stability and Activity via Noncatalytic Ubiquitin-binding Domains

(2011) Marzia Scortegagna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia

(2011) D J P M Stumpel et al.   LEUKEMIA

The heterodimerization domains of MLL—FYRN and FYRC—are potential target structures in t(4;11) leukemia

(2011) B Pless et al.   LEUKEMIA

The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia

(2011) B V Balgobind et al.   LEUKEMIA

Dynamics of the emergence of dasatinib and nilotinib resistance in imatinib-resistant CML patients

(2011) F X Gruber et al.   LEUKEMIA

Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and ‘retreatment’ approaches in the era of novel agents

(2011) B Mohty et al.   LEUKEMIA

The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma

(2011) S K Martin et al.   LEUKEMIA

Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy

(2011) M Gupta et al.   LEUKEMIA

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy

(2011) L S Steelman et al.   LEUKEMIA

Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1

(2011) Huiling Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PAX5–PML acts as a dual dominant-negative form of both PAX5 and PML

(2011) S Kurahashi et al.   ONCOGENE

BAG1: The Guardian of Anti-Apoptotic Proteins in Acute Myeloid Leukemia

(2011) Sanja Aveic et al.   PLoS One

The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

(2011) L. Wang et al.   SCIENCE

The Importin-Alpha/Nucleophosmin Switch Controls Taspase1 Protease Function

(2011) Carolin Bier et al.   TRAFFIC

Inhibiting aberrant Stat3 function with molecular therapeutics

(2010) Sina Haftchenary et al.   ANTI-CANCER DRUGS

SIAH-1 interacts with mammalian polyhomeotic homologues HPH2 and affects its stability via the ubiquitin–proteasome pathway

(2010) Huiling Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Ski protein negatively regulates Siah2-mediated HDAC3 degradation

(2010) Hong-Ling Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4

(2010) A. Bursen et al.   BLOOD

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity

(2010) C. Wichmann et al.   BLOOD

AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit

(2010) T.-Y. Lin et al.   BLOOD

Mechanisms of leukemogenesis by MLL fusion proteins

(2010) Rolf Marschalek   BRITISH JOURNAL OF HAEMATOLOGY

HtrA2, taming the oncogenic activities of WT1

(2010) Jörg Hartkamp et al.   CELL CYCLE

Inhibitors of HDACs - Effective Drugs Against Cancer?

(2010) S. Muller et al.   CURRENT CANCER DRUG TARGETS

Molecular Targeting of Aberrant Transcription Factors in Leukemia: Strategies for RUNX1/ETO

(2010) Christian Wichmann et al.   CURRENT DRUG TARGETS

The molecular signature of oncofusion proteins in acute myeloid leukemia

(2010) Joost H.A. Martens et al.   FEBS LETTERS

Cell-based Analysis of Structure-Function Activity of Threonine Aspartase 1

(2010) Carolin Bier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunohistochemical Methods for Predicting Cell of Origin and Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab

(2010) Paul N. Meyer et al.   JOURNAL OF CLINICAL ONCOLOGY

Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation

(2010) M Buchwald et al.   LEUKEMIA

The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures

(2010) A Benedikt et al.   LEUKEMIA

Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia

(2010) A Quintás-Cardama et al.   LEUKEMIA

Discovery and Characterization of Novel Mutant FLT3 Kinase Inhibitors

(2010) E. Weisberg et al.   MOLECULAR CANCER THERAPEUTICS

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Deconstructing repression: evolving models of co-repressor action

(2010) Valentina Perissi et al.   NATURE REVIEWS GENETICS

Drug resistance in mutant FLT3-positive AML

(2010) E Weisberg et al.   ONCOGENE

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

Identification of AML1-ETO modulators by chemical genomics

(2009) S. M. Corsello et al.   BLOOD

Cotreatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplastic cells

(2009) Y. Wang et al.   BLOOD

Bis(1H-indol-2-yl)methanones are effective inhibitors of FLT3-ITD tyrosine kinase and partially overcome resistance to PKC412Ain vitro

(2009) Florian Heidel et al.   BRITISH JOURNAL OF HAEMATOLOGY

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1

(2009) Se-Yong Kim et al.   CANCER LETTERS

HDACi – Targets beyond chromatin

(2009) Marc Buchwald et al.   CANCER LETTERS

Siah Proteins: Novel Drug Targets in the Ras and Hypoxia Pathways

(2009) C. M. House et al.   CANCER RESEARCH

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

New insights to the MLL recombinome of acute leukemias

(2009) C Meyer et al.   LEUKEMIA

PML–RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

(2009) S Wojiski et al.   LEUKEMIA

Proteasome inhibitors in the treatment of multiple myeloma

(2009) J J Shah et al.   LEUKEMIA

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE

Inhibition of Siah2 ubiquitin ligase by vitamin K3 (menadione) attenuates hypoxia and MAPK signaling and blocks melanoma tumorigenesis

(2009) Meera Shah et al.   Pigment Cell & Melanoma Research

HDAC2: a critical factor in health and disease

(2009) Oliver H. Krämer   TRENDS IN PHARMACOLOGICAL SCIENCES

Hexachlorophene suppresses β-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells

(2008) Hye-Jin Min et al.   CANCER LETTERS

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

(2008) M. G. Guenther et al.   GENES & DEVELOPMENT

E2F1 represses β-catenin/TCF activity by direct up-regulation of Siah1

(2008) Wei Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth

(2008) Atique U. Ahmed et al.   JNCI-Journal of the National Cancer Institute

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

(2008) Chie Nishioka et al.   LEUKEMIA RESEARCH

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response

(2008) Marco A. Calzado et al.   NATURE CELL BIOLOGY

TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels

(2008) Mohammad Shahidul Makki et al.   NUCLEIC ACIDS RESEARCH

Review: genetic models of acute myeloid leukaemia

(2008) E McCormack et al.   ONCOGENE

Gatekeeper function of the RUNX1 transcription factor in acute leukemia

(2007) Birte Niebuhr et al.   BLOOD CELLS MOLECULES AND DISEASES

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARα

(2007) Oliver H. Krämer et al.   FASEB JOURNAL