Scintillation proximity assay (SPA) as a new approach to determine a ligand’s kinetic profile. A case in point for the adenosine A1 receptor

Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance

(2015) Nicolas Bocquet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists

(2015) Jacobus P.D. van Veldhoven et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A2Areceptor reconstituted in HDL like particles

(2015) Elena Segala et al.   FEBS LETTERS

A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands

(2014) David C Swinney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A2AReceptor

(2014) Dong Guo et al.   ChemMedChem

Drug-Target Residence Time-A Case for G Protein-Coupled Receptors

(2014) Dong Guo et al.   MEDICINAL RESEARCH REVIEWS

Structure–Kinetic Relationships—An Overlooked Parameter in Hit-to-Lead Optimization: A Case of Cyclopentylamines as Chemokine Receptor 2 Antagonists

(2013) Maris Vilums et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

(2012) Dong Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Measuring substrate binding and affinity of purified membrane transport proteins using the scintillation proximity assay

(2012) Daniel Harder et al.   Nature Protocols

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor

(2010) Gregori J. Morriello et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor

(2009) D. A. Sykes et al.   MOLECULAR PHARMACOLOGY

Scintillation Proximity Assays in High-Throughput Screening

(2008) J. Fraser Glickman et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2- ]pyridine-8-carboxamide (CJ-033,466), a Novel and Selective 5-Hydroxytryptamine4 Receptor Partial Agonist: Pharmacological Profile in Vitro and Gastroprokinetic Effect in Conscious Dogs

(2008) T. Mikami et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS