Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A2AReceptor

Novel adenosine A2A receptor ligands: A synthetic, functional and computational investigation of selected literature adenosine A2A receptor antagonists for extending into extracellular space

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Functional efficacy of adenosine A2A receptor agonists is positively correlated to their receptor residence time

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Structure and dynamics of the M3 muscarinic acetylcholine receptor

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A2A antagonist, ZM 241385

(2012) Manuela Jörg et al.   STRUCTURAL CHEMISTRY

Adenosine A2A Receptor Antagonists and Parkinson’s Disease

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Target–drug interactions: first principles and their application to drug discovery

(2011) Sara Núñez et al.   DRUG DISCOVERY TODAY

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Recent developments in adenosine receptor ligands and their potential as novel drugs

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Binding kinetics and mechanism of action: toward the discovery and development of better and best in class drugs

(2010) Rumin Zhang et al.   Expert Opinion on Drug Discovery

Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled β2-adrenoceptor agonists

(2010) Elizabeth M. Rosethorne et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Fast on-rates allow short dwell time ligands to activate T cells

(2010) C. C. Govern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAR of a series of inhaled A2A agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data

(2009) Simon J. Mantell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Early integration of pharmacokinetic and dynamic reasoning is essential for optimal development of lead compounds: strategic considerations

(2009) Johan Gabrielsson et al.   DRUG DISCOVERY TODAY

Exploring the Mechanism of Agonist Efficacy: A Relationship between Efficacy and Agonist Dissociation Rate at the Muscarinic M3 Receptor

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An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles

(2009) Anton V. Dolzhenko et al.   TETRAHEDRON LETTERS

Inhaled adenosine A2A receptor agonists for the treatment of chronic obstructive pulmonary disease

(2008) Simon J. Mantell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS