Biosensor-based affinities and binding kinetics of small molecule antagonists to the adenosine A2Areceptor reconstituted in HDL like particles

Binding Kinetics of ZM241385 Derivatives at the Human Adenosine A2AReceptor

(2014) Dong Guo et al.   ChemMedChem

Kinetics of the early events of GPCR signalling

(2014) Roslin J. Adamson et al.   FEBS LETTERS

High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875

(2014) Ankita Srivastava et al.   NATURE

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Biophysical Fragment Screening of the β1-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

(2013) John A. Christopher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

(2013) Tonia Aristotelous et al.   ACS Medicinal Chemistry Letters

HDL-like discs for assaying membrane proteins in drug discovery

(2012) Cédric Fiez-Vandal et al.   BIOPHYSICAL CHEMISTRY

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

(2012) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biophysical Mapping of the Adenosine A2AReceptor

(2011) Andrei Zhukov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Biacore analysis with stabilized G-protein-coupled receptors

(2010) Rebecca L. Rich et al.   ANALYTICAL BIOCHEMISTRY

Nanodiscs allow the use of integral membrane proteins as analytes in surface plasmon resonance studies

(2010) Julian M. Glück et al.   ANALYTICAL BIOCHEMISTRY

Application of Fragment-Based Drug Discovery to Membrane Proteins: Identification of Ligands of the Integral Membrane Enzyme DsbB

(2010) Virginie Früh et al.   CHEMISTRY & BIOLOGY

Drug–target residence time: critical information for lead optimization

(2010) Hao Lu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery

(2010) Nathan Robertson et al.   NEUROPHARMACOLOGY

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors

(2009) Adam J. Kuszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanodiscs for Immobilization of Lipid Bilayers and Membrane Receptors: Kinetic Analysis of Cholera Toxin Binding to a Glycolipid Receptor

(2008) Jonas Borch et al.   ANALYTICAL CHEMISTRY

Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles

(2008) Sourabh Banerjee et al.   JOURNAL OF MOLECULAR BIOLOGY

The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure

(2007) P Kalk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantifying the association and dissociation rates of unlabelled antagonists at the muscarinic M3 receptor

(2006) Mark R Dowling et al.   BRITISH JOURNAL OF PHARMACOLOGY