A 96-well microplate bioreactor platform supporting individual dual perfusion and high-throughput assessment of simple or biofabricated 3D tissue models

Pressure-actuated monolithic acrylic microfluidic valves and pumps

(2018) Pablo E. Guevara-Pantoja et al.   LAB ON A CHIP

3D printed high density, reversible, chip-to-chip microfluidic interconnects

(2018) Hua Gong et al.   LAB ON A CHIP

A new class of magnetically actuated pumps and valves for microfluidic applications

(2018) Joshua K. Hamilton et al.   Scientific Reports

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS)

(2017) Christian Maass et al.   Integrative Biology

µ-Particle tracking velocimetry and computational fluid dynamics study of cell seeding within a 3D porous scaffold

(2017) A. Campos Marin et al.   Journal of the Mechanical Behavior of Biomedical Materials

Micro-engineered perfusable 3D vasculatures for cardiovascular diseases

(2017) Nishanth Venugopal Menon et al.   LAB ON A CHIP

Design considerations to minimize the impact of drug absorption in polymer-based organ-on-a-chip platforms

(2017) V. S. Shirure et al.   LAB ON A CHIP

Precision control of flow rate in microfluidic channels using photoresponsive soft polymer actuators

(2017) Colm Delaney et al.   LAB ON A CHIP

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

“Open-top” microfluidic device for in vitro three-dimensional capillary beds

(2017) Soojung Oh et al.   LAB ON A CHIP

A portable and reconfigurable multi-organ platform for drug development with onboard microfluidic flow control

(2017) J. R. Coppeta et al.   LAB ON A CHIP

A loop of cancer-stroma-cancer interaction promotes peritoneal metastasis of ovarian cancer via TNFα-TGFα-EGFR

(2017) T-S Lau et al.   ONCOGENE

Flow velocity-driven differentiation of human mesenchymal stromal cells in silk fibroin scaffolds: A combined experimental and computational approach

(2017) Jolanda Rita Vetsch et al.   PLoS One

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

(2017) Yu Shrike Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage

(2017) Christoph Meinert et al.   Scientific Reports

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

(2017) Ying I. Wang et al.   Advanced Healthcare Materials

Bioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue

(2017) Batzaya Byambaa et al.   Advanced Healthcare Materials

96 perfusable blood vessels to study vascular permeability in vitro

(2017) V. van Duinen et al.   Scientific Reports

Modular Tissue Assembly Strategies for Biofabrication of Engineered Cartilage

(2016) B. S. Schon et al.   ANNALS OF BIOMEDICAL ENGINEERING

2D µ-Particle Image Velocimetry and Computational Fluid Dynamics Study Within a 3D Porous Scaffold

(2016) A. Campos Marin et al.   ANNALS OF BIOMEDICAL ENGINEERING

3D Printing of Tissue Engineered Constructs for In Vitro Modeling of Disease Progression and Drug Screening

(2016) Joseph Vanderburgh et al.   ANNALS OF BIOMEDICAL ENGINEERING

Experimental Approach to Visualize Flow in a Stacked Hollow Fiber Bundle of an Artificial Lung With Particle Image Velocimetry

(2016) Andreas Kaesler et al.   ARTIFICIAL ORGANS

Guidelines for the selection of functional assays to evaluate the hallmarks of cancer

(2016) Otília Menyhárt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Characterization of a novel bioreactor system for 3D cellular mechanobiology studies

(2016) Colin A. Cook et al.   BIOTECHNOLOGY AND BIOENGINEERING

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

Quantitative imaging of excised osteoarthritic cartilage using spectral CT

(2016) Kishore Rajendran et al.   EUROPEAN RADIOLOGY

3D printed nervous system on a chip

(2016) Blake N. Johnson et al.   LAB ON A CHIP

High-throughput imaging: Focusing in on drug discovery in 3D

(2016) Linfeng Li et al.   METHODS

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

(2016) Daniela Loessner et al.   Nature Protocols

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Angiogenesis in tissue-engineered nerves evaluated objectively using MICROFIL perfusion and micro-CT scanning

(2016) Xiao-song Gu et al.   Neural Regeneration Research

A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models

(2016) Nathalie Picollet-D’hahan et al.   TRENDS IN BIOTECHNOLOGY

Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels

(2016) Keely A. Heintz et al.   Advanced Healthcare Materials

Drug screening in 3D in vitro tumor models: overcoming current pitfalls of efficacy read-outs

(2016) Vítor E. Santo et al.   Biotechnology Journal

New Visible-Light Photoinitiating System for Improved Print Fidelity in Gelatin-Based Bioinks

(2016) Khoon S. Lim et al.   ACS Biomaterials-Science & Engineering

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials-Science & Engineering

Biomimetic on-a-chip platforms for studying cancer metastasis

(2016) Esak Lee et al.   Current Opinion in Chemical Engineering

New Visible-Light Photoinitiating System for Improved Print Fidelity in Gelatin-Based Bioinks

(2016) Khoon S. Lim et al.   ACS Biomaterials Science & Engineering

Bioprinting the Cancer Microenvironment

(2016) Yu Shrike Zhang et al.   ACS Biomaterials Science & Engineering

High-Throughput 3D Tumor Spheroid Screening Method for Cancer Drug Discovery Using Celigo Image Cytometry

(2016) Sarah Kessel et al.   SLAS Technology

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform

(2016) Nienke R. Wevers et al.   Scientific Reports

Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

(2015) Sitta Sittampalam et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

(2015) Ilka Maschmeyer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Emulating human microcapillaries in a multi-organ-chip platform

(2015) Tobias Hasenberg et al.   JOURNAL OF BIOTECHNOLOGY

A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing

(2015) Eva-Maria Materne et al.   JOURNAL OF BIOTECHNOLOGY

Bubble pump: scalable strategy for in-plane liquid routing

(2015) Ali Oskooei et al.   LAB ON A CHIP

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy

(2015) Hilary A. Kenny et al.   Nature Communications

Cancer-Associated Fibroblasts and Their Putative Role in Potentiating the Initiation and Development of Epithelial Ovarian Cancer

(2015) Isaiah G. Schauer et al.   NEOPLASIA

Microvascular Endothelial Cells Migrate Upstream and Align Against the Shear Stress Field Created by Impinging Flow

(2014) Maggie A. Ostrowski et al.   BIOPHYSICAL JOURNAL

X-ray phase contrast imaging of calcified tissue and biomaterial structure in bioreactor engineered tissues

(2014) Alyssa A. Appel et al.   BIOTECHNOLOGY AND BIOENGINEERING

Stem Cell-Based Microphysiological Osteochondral System to Model Tissue Response to Interleukin-1β

(2014) Hang Lin et al.   MOLECULAR PHARMACEUTICS

Multiplexing Spheroid Volume, Resazurin and Acid Phosphatase Viability Assays for High-Throughput Screening of Tumour Spheroids and Stem Cell Neurospheres

(2014) Delyan P. Ivanov et al.   PLoS One

Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues

(2014) Zi Di et al.   PLoS One

Fluid shear stress threshold regulates angiogenic sprouting

(2014) P. A. Galie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis

(2014) Olivier Frey et al.   Nature Communications

Gelatin hydrogels formed by orthogonal thiol–norbornene photochemistry for cell encapsulation

(2014) Zachary Mũnoz et al.   Biomaterials Science

Tissue engineering perfusable cancer models

(2014) EL Fong et al.   Current Opinion in Chemical Engineering

Poly(vinyl alcohol)-heparin biosynthetic microspheres produced by microfluidics and ultraviolet photopolymerisation

(2013) Cara Young et al.   Biomicrofluidics

The role ofin vitromethods as alternatives to animals in toxicity testing

(2013) Arturo Anadón et al.   Expert Opinion on Drug Metabolism & Toxicology

On being the right size: scaling effects in designing a human-on-a-chip

(2013) Christopher Moraes et al.   Integrative Biology

Microfluidic titer plate for stratified 3D cell culture

(2013) Sebastiaan J. Trietsch et al.   LAB ON A CHIP

Three-Dimensional Characterization of Tissue-Engineered Constructs by Contrast-Enhanced Nanofocus Computed Tomography

(2013) Ioannis Papantoniou et al.   TISSUE ENGINEERING PART C-METHODS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

A metering rotary nanopump for microfluidic systems

(2010) Scott G. Darby et al.   LAB ON A CHIP

The return of a forgotten polymer—Polycaprolactone in the 21st century

(2010) Maria Ann Woodruff et al.   PROGRESS IN POLYMER SCIENCE

Automatic Quantitative Micro-Computed Tomography Evaluation of Angiogenesis in an Axially Vascularized Tissue-Engineered Bone Construct

(2010) Andreas Arkudas et al.   TISSUE ENGINEERING PART C-METHODS

A Novel Flex-Stretch-Flow Bioreactor for the Study of Engineered Heart Valve Tissue Mechanobiology

(2008) George C. Engelmayr et al.   ANNALS OF BIOMEDICAL ENGINEERING

Design of a Modular Bioreactor to Incorporate Both Perfusion Flow and Hydrostatic Compression for Tissue Engineering Applications

(2008) David E. Orr et al.   ANNALS OF BIOMEDICAL ENGINEERING

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS