Exposing the subunit diversity and modularity of protein complexes by structural mass spectrometry approaches

A Mutually Inhibitory Feedback Loop between the 20S Proteasome and Its Regulator, NQO1

(2015) Oren Moscovitz et al.   MOLECULAR CELL

Action-FRET: Probing the Molecular Conformation of Mass-Selected Gas-Phase Peptides with Förster Resonance Energy Transfer Detected by Acceptor-Specific Fragmentation

(2014) Steven Daly et al.   ANALYTICAL CHEMISTRY

From the Human Genome to the Human Proteome

(2014) Javier Muñoz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analytical Approaches for Size and Mass Analysis of Large Protein Assemblies

(2014) Joost Snijder et al.   Annual Review of Analytical Chemistry

Top Down proteomics: Facts and perspectives

(2014) Adam D. Catherman et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of the subunit organization of the eIF2B complex reveals new insights into its structure and regulation

(2014) Noel C. Wortham et al.   FASEB JOURNAL

Dynamic protein ligand interactions - insights from MS

(2014) Carla Schmidt et al.   FEBS Journal

Label-Free Quantitative Proteomics Reveals the Dynamics of Proteasome Complexes Composition and Stoichiometry in a Wide Range of Human Cell Lines

(2014) Bertrand Fabre et al.   JOURNAL OF PROTEOME RESEARCH

Collision-Induced Release, Ion Mobility Separation, and Amino Acid Sequence Analysis of Subunits from Mass-Selected Noncovalent Protein Complexes

(2014) Deepali Rathore et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Boundaries of Mass Resolution in Native Mass Spectrometry

(2014) Philip Lössl et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Histone H2A.Z subunit exchange controls consolidation of recent and remote memory

(2014) Iva B. Zovkic et al.   NATURE

Global analysis of protein structural changes in complex proteomes

(2014) Yuehan Feng et al.   NATURE BIOTECHNOLOGY

The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics

(2014) Francesco Lanucara et al.   Nature Chemistry

A mass spectrometry–based hybrid method for structural modeling of protein complexes

(2014) Argyris Politis et al.   NATURE METHODS

A comparative cross-linking strategy to probe conformational changes in protein complexes

(2014) Carla Schmidt et al.   Nature Protocols

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes

(2014) Alexander Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spec Studio for Integrative Structural Biology

(2014) Martial Rey et al.   STRUCTURE

Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex

(2014) Dror S. Chorev et al.   Nature Communications

eIF2B is a decameric guanine nucleotide exchange factor with a γ2ε2 tetrameric core

(2014) Yuliya Gordiyenko et al.   Nature Communications

Time Resolved Native Ion-Mobility Mass Spectrometry to Monitor Dynamics of IgG4 Fab Arm Exchange and “Bispecific” Monoclonal Antibody Formation

(2013) François Debaene et al.   ANALYTICAL CHEMISTRY

From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry

(2013) Mikhail E. Belov et al.   ANALYTICAL CHEMISTRY

Analyzing Protein Micro-Heterogeneity in Chicken Ovalbumin by High-Resolution Native Mass Spectrometry Exposes Qualitatively and Semi-Quantitatively 59 Proteoforms

(2013) Yang Yang et al.   ANALYTICAL CHEMISTRY

Mass spectrometry supported determination of protein complex structure

(2013) Thomas Walzthoeni et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

(2013) Hui Wei et al.   DRUG DISCOVERY TODAY

Deciphering post-translational modification codes

(2013) Adam P. Lothrop et al.   FEBS LETTERS

The Effects of Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) on Protein–Protein Interactions

(2013) Christopher M. Yates et al.   JOURNAL OF MOLECULAR BIOLOGY

In-depth qualitative and quantitative analysis of composite glycosylation profiles and other micro-heterogeneity on intact monoclonal antibodies by high-resolution native mass spectrometry using a modified Orbitrap

(2013) Sara Rosati et al.   mAbs

Exposing the subunit diversity within protein complexes: A mass spectrometry approach

(2013) Shelly Rozen et al.   METHODS

Structure and Activity of the RNA-Targeting Type III-B CRISPR-Cas Complex of Thermus thermophilus

(2013) Raymond H.J. Staals et al.   MOLECULAR CELL

Structure of the CRISPR Interference Complex CSM Reveals Key Similarities with Cascade

(2013) Christophe Rouillon et al.   MOLECULAR CELL

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural MS Pulls Its Weight

(2013) M. Sharon   SCIENCE

Comparative cross-linking and mass spectrometry of an intact F-type ATPase suggest a role for phosphorylation

(2013) Carla Schmidt et al.   Nature Communications

Post-translational modifications induce significant yet not extreme changes to protein structure

(2012) Fuxiao Xin et al.   BIOINFORMATICS

Targeted proteome investigation via selected reaction monitoring mass spectrometry

(2012) Alessio Maiolica et al.   Journal of Proteomics

Proteomics in chromatin biology and epigenetics: Elucidation of post-translational modifications of histone proteins by mass spectrometry

(2012) Simone Sidoli et al.   Journal of Proteomics

A Cell-Based Approach to the Human Proteome Project

(2012) Neil L. Kelleher   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Subcellular Distribution and Dynamics of Active Proteasome Complexes Unraveled by a Workflow Combiningin VivoComplex Cross-Linking and Quantitative Proteomics

(2012) Bertrand Fabre et al.   MOLECULAR & CELLULAR PROTEOMICS

Native Tandem and Ion Mobility Mass Spectrometry Highlight Structural and Modular Similarities in Clustered-Regularly-Interspaced Shot-Palindromic-Repeats (CRISPR)-associated Protein Complexes FromEscherichia coliandPseudomonas aeruginosa

(2012) Esther van Duijn et al.   MOLECULAR & CELLULAR PROTEOMICS

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions

(2012) Paola Picotti et al.   NATURE METHODS

Gene duplication as a mechanism of genomic adaptation to a changing environment

(2012) F. A. Kondrashov   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies

(2011) Hao Zhang et al.   ANALYTICAL CHEMISTRY

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

(2011) Mehdi Mollapour et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The role of protein conformational fluctuations in allostery, function, and evolution

(2011) James O. Wrabl et al.   BIOPHYSICAL CHEMISTRY

Capturing protein structural kinetics by mass spectrometry

(2011) Gili Ben-Nissan et al.   CHEMICAL SOCIETY REVIEWS

Protein folding mechanisms studied by pulsed oxidative labeling and mass spectrometry

(2011) Lars Konermann et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Quaternary Dynamics of αB-Crystallin as a Direct Consequence of Localised Tertiary Fluctuations in the C-Terminus

(2011) Andrew J. Baldwin et al.   JOURNAL OF MOLECULAR BIOLOGY

Mapping intact protein isoforms in discovery mode using top-down proteomics

(2011) John C. Tran et al.   NATURE

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions

(2011) Eman Basha et al.   TRENDS IN BIOCHEMICAL SCIENCES

How useful is ion mobility mass spectrometry for structural biology? The relationship between protein crystal structures and their collision cross sections in the gas phase

(2010) Ewa Jurneczko et al.   ANALYST

Hydrogen exchange mass spectrometry for studying protein structure and dynamics

(2010) Lars Konermann et al.   CHEMICAL SOCIETY REVIEWS

Future directions of structural mass spectrometry using hydroxyl radical footprinting

(2010) Janna G. Kiselar et al.   JOURNAL OF MASS SPECTROMETRY

Separating and visualising protein assemblies by means of preparative mass spectrometry and microscopy

(2010) Justin L.P. Benesch et al.   JOURNAL OF STRUCTURAL BIOLOGY

Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

(2010) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

Alternative translation start sites are conserved in eukaryotic genomes

(2010) G. A. Bazykin et al.   NUCLEIC ACIDS RESEARCH

Gas-phase fluorescence excitation and emission spectroscopy of mass-selected trapped molecular ions

(2010) Qunzhou Bian et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Between a chicken and a grape: estimating the number of human genes

(2010) Mihaela Pertea et al.   GENOME BIOLOGY

Proteomics by Mass Spectrometry: Approaches, Advances, and Applications

(2009) John R. Yates et al.   Annual Review of Biomedical Engineering

Nucleotide- and Activator-Dependent Structural and Dynamic Changes of Arp2/3 Complex Monitored by Hydrogen/Deuterium Exchange and Mass Spectrometry

(2009) Wendy D. Zencheck et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural implication of splicing stochastics

(2009) E. Melamud et al.   NUCLEIC ACIDS RESEARCH

The speciation of the proteome

(2008) Peter R Jungblut et al.   Chemistry Central Journal

Mass spectrometry for proteomics

(2008) Xuemei Han et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Alternative isoform regulation in human tissue transcriptomes

(2008) Eric T. Wang et al.   NATURE

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Ion mobility–mass spectrometry analysis of large protein complexes

(2008) Brandon T Ruotolo et al.   Nature Protocols