The emerging role of native mass spectrometry in characterizing the structure and dynamics of macromolecular complexes

Topological Models of Heteromeric Protein Assemblies from Mass Spectrometry: Application to the Yeast eIF3:eIF5 Complex

(2015) Argyris Politis et al.   CHEMISTRY & BIOLOGY

Novel insights into nickel import in Staphylococcus aureus: the positive role of free histidine and structural characterization of a new thiazolidine-type nickel chelator

(2015) H. Lebrette et al.   Metallomics

Nanodiscs and Electrospray Ionization Mass Spectrometry: A Tool for Screening Glycolipids Against Proteins

(2014) Aneika C. Leney et al.   ANALYTICAL CHEMISTRY

Mass-Selective Soft-Landing of Protein Assemblies with Controlled Landing Energies

(2014) Victor A. Mikhailov et al.   ANALYTICAL CHEMISTRY

Amphipols Outperform Dodecylmaltoside Micelles in Stabilizing Membrane Protein Structure in the Gas Phase

(2014) Antonio N. Calabrese et al.   ANALYTICAL CHEMISTRY

Matrix-Assisted Ionization Vacuum for High-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometers

(2014) Beixi Wang et al.   ANALYTICAL CHEMISTRY

Analytical Approaches for Size and Mass Analysis of Large Protein Assemblies

(2014) Joost Snijder et al.   Annual Review of Analytical Chemistry

Dynamic protein ligand interactions - insights from MS

(2014) Carla Schmidt et al.   FEBS Journal

Defining the Stoichiometry and Cargo Load of Viral and Bacterial Nanoparticles by Orbitrap Mass Spectrometry

(2014) Joost Snijder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Charge Reduction Stabilizes Intact Membrane Protein Complexes for Mass Spectrometry

(2014) Shahid Mehmood et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Detection of Late Intermediates in Virus Capsid Assembly by Charge Detection Mass Spectrometry

(2014) Elizabeth E. Pierson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insights into the Mechanism of Protein Electrospray Ionization From Salt Adduction Measurements

(2014) Xuanfeng Yue et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Mass Spectrometric Strategies to Improve the Identification of Pt(II)-Modification Sites on Peptides and Proteins

(2014) Huilin Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Revealing Ligand Binding Sites and Quantifying Subunit Variants of Noncovalent Protein Complexes in a Single Native Top-Down FTICR MS Experiment

(2014) Huilin Li et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

ETD Allows for Native Surface Mapping of a 150 kDa Noncovalent Complex on a Commercial Q-TWIMS-TOF Instrument

(2014) Frederik Lermyte et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry

(2014) Rebecca H. Wills et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

What Protein Charging (and Supercharging) Reveal about the Mechanism of Electrospray Ionization

(2014) Rachel R. Ogorzalek Loo et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

(2014) Raymond H.J. Staals et al.   MOLECULAR CELL

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Ion mobility–mass spectrometry of a rotary ATPase reveals ATP-induced reduction in conformational flexibility

(2014) Min Zhou et al.   Nature Chemistry

A mass spectrometry–based hybrid method for structural modeling of protein complexes

(2014) Argyris Politis et al.   NATURE METHODS

Ten years of Methods

(2014)   NATURE METHODS

Type III restriction endonucleases are heterotrimeric: comprising one helicase–nuclease subunit and a dimeric methyltransferase that binds only one specific DNA

(2014) Annika Butterer et al.   NUCLEIC ACIDS RESEARCH

Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry

(2014) Albert Konijnenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometry Defines the C-Terminal Dimerization Domain and Enables Modeling of the Structure of Full-Length OmpA

(2014) Julien Marcoux et al.   STRUCTURE

Substrate Occupancy at the Onset of Oligomeric Transitions of DegP

(2014) Natalie J. Thompson et al.   STRUCTURE

Regulation of focal adhesion formation by a vinculin-Arp2/3 hybrid complex

(2014) Dror S. Chorev et al.   Nature Communications

From Protein Complexes to Subunit Backbone Fragments: A Multi-stage Approach to Native Mass Spectrometry

(2013) Mikhail E. Belov et al.   ANALYTICAL CHEMISTRY

New Ionization Method for Analysis on Atmospheric Pressure Ionization Mass Spectrometers Requiring Only Vacuum and Matrix Assistance

(2013) Sarah Trimpin et al.   ANALYTICAL CHEMISTRY

Orbitrap Mass Spectrometry

(2013) Roman A. Zubarev et al.   ANALYTICAL CHEMISTRY

Studying 18 MDa Virus Assemblies with Native Mass Spectrometry

(2013) Joost Snijder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

p-Sulfonato-calix[n]arenes inhibit staphylococcal bicomponent leukotoxins by supramolecular interactions

(2013) Benoît-Joseph Laventie et al.   BIOCHEMICAL JOURNAL

Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

(2013) Douglas Marcotte et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein Complexes Are under Evolutionary Selection to Assemble via Ordered Pathways

(2013) Joseph A. Marsh et al.   CELL

Ion mobility-mass spectrometry of intact protein–ligand complexes for pharmaceutical drug discovery and development

(2013) Shuai Niu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Intact protein mass spectrometry and top-down proteomics

(2013) Julian Whitelegge   Expert Review of Proteomics

Native mass spectrometry of photosynthetic pigment-protein complexes

(2013) Hao Zhang et al.   FEBS LETTERS

Detergent Release Prolongs the Lifetime of Native-like Membrane Protein Conformations in the Gas-Phase

(2013) Antoni J. Borysik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exposing the subunit diversity within protein complexes: A mass spectrometry approach

(2013) Shelly Rozen et al.   METHODS

The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

(2013) Matthias Mann et al.   MOLECULAR CELL

Probing the biophysical interplay between a viral genome and its capsid

(2013) J. Snijder et al.   Nature Chemistry

Detergent-free mass spectrometry of membrane protein complexes

(2013) Jonathan T S Hopper et al.   NATURE METHODS

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Mass spectrometry of intact membrane protein complexes

(2013) Arthur Laganowsky et al.   Nature Protocols

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump

(2013) J. Marcoux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric mechanisms can be distinguished using structural mass spectrometry

(2013) A. Dyachenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal packing modifies ligand binding affinity: The case of aldose reductase

(2013) Alexandra Cousido-Siah et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Intrinsically Disordered Protein Threads Through the Bacterial Outer-Membrane Porin OmpF

(2013) N. G. Housden et al.   SCIENCE

Architecture of a dsDNA Viral Capsid in Complex with Its Maturation Protease

(2013) David Veesler et al.   STRUCTURE

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis

(2012) Sung Hwan Yoon et al.   ANALYTICAL CHEMISTRY

Massign: An Assignment Strategy for Maximizing Information from the Mass Spectra of Heterogeneous Protein Assemblies

(2012) Nina Morgner et al.   ANALYTICAL CHEMISTRY

Native Mass Spectrometry Characterization of Intact Nanodisc Lipoprotein Complexes

(2012) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

(2012) Sara Rosati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Native ion mobility-mass spectrometry and related methods in structural biology

(2012) A. Konijnenberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Linking structural change with functional regulation—insights from mass spectrometry

(2012) Nina Morgner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure, stability and dynamics of norovirus P domain derived protein complexes studied by native mass spectrometry

(2012) Jessica Z. Bereszczak et al.   JOURNAL OF STRUCTURAL BIOLOGY

Surface Acoustic Wave Nebulization Produces Ions with Lower Internal Energy than Electrospray Ionization

(2012) Yue Huang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Charge Detection Mass Spectrometry with Resolved Charge States

(2012) Nathan C. Contino et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Spinning up mass spectrometry for whole protein complexes

(2012) Philip D Compton et al.   NATURE METHODS

High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

(2012) Rebecca J Rose et al.   NATURE METHODS

Single-protein nanomechanical mass spectrometry in real time

(2012) M. S. Hanay et al.   Nature Nanotechnology

In vivo protein complex topologies: Sights through a cross-linking lens

(2012) James E. Bruce   PROTEOMICS

Top-down mass spectrometry: Recent developments, applications and perspectives

(2011) Weidong Cui et al.   ANALYST

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

(2011) Samuel M. Meier et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Structural Analysis of Intact Monoclonal Antibodies by Electron Transfer Dissociation Mass Spectrometry

(2011) Yury O. Tsybin et al.   ANALYTICAL CHEMISTRY

Quantifying Protein–Protein Interactions Within Noncovalent Complexes Using Electrospray Ionization Mass Spectrometry

(2011) Elisabetta Boeri Erba et al.   ANALYTICAL CHEMISTRY

Native Electrospray and Electron-Capture Dissociation FTICR Mass Spectrometry for Top-Down Studies of Protein Assemblies

(2011) Hao Zhang et al.   ANALYTICAL CHEMISTRY

Interpreting the Charge State Assignment in Electrospray Mass Spectra of Bioparticles

(2011) Yao-Hsin Tseng et al.   ANALYTICAL CHEMISTRY

Modern Biomolecular Mass Spectrometry and its Role in Studying Virus Structure, Dynamics, and Assembly

(2011) Charlotte Uetrecht et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oligomeric Structure of ExbB and ExbB-ExbD Isolated fromEscherichia coliAs Revealed by LILBID Mass Spectrometry

(2011) Avijit Pramanik et al.   BIOCHEMISTRY

Mass spectrometry: come of age for structural and dynamical biology

(2011) Justin LP Benesch et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Investigating a macromolecular complex: The toolkit of methods

(2011) Anastassis Perrakis et al.   JOURNAL OF STRUCTURAL BIOLOGY

Monitoring the Dynamics of Monomer Exchange Using Electrospray Mass Spectrometry: The Case of the Dimeric Glucosamine-6-Phosphate Synthase

(2011) Guillaume Chevreux et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Electron Capture, Collision-Induced, and Electron Capture-Collision Induced Dissociation in Q-TOF

(2011) Valery G. Voinov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Fourier Transform Mass Spectrometry

(2011) Michaela Scigelova et al.   MOLECULAR & CELLULAR PROTEOMICS

Principles of Electrospray Ionization

(2011) Matthias Wilm   MOLECULAR & CELLULAR PROTEOMICS

Multimeric assembly and biochemical characterization of the Trax–translin endonuclease complex

(2011) Yuan Tian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for CRISPR RNA-guided DNA recognition by Cascade

(2011) Matthijs M Jore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heterogeneity and dynamics in the assembly of the Heat Shock Protein 90 chaperone complexes

(2011) I.-o. Ebong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

(2011) B. Wiedenheft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mass Spectrometry of Intact V-Type ATPases Reveals Bound Lipids and the Effects of Nucleotide Binding

(2011) M. Zhou et al.   SCIENCE

Surface Acoustic Wave Nebulization of Peptides As a Microfluidic Interface for Mass Spectrometry

(2010) Scott R. Heron et al.   ANALYTICAL CHEMISTRY

Combination of Noncovalent Mass Spectrometry and Traveling Wave Ion Mobility Spectrometry Reveals Sugar-Induced Conformational Changes of Central Glycolytic Genes Repressor/DNA Complex

(2010) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Ion Mobility-Mass Spectrometry Reveals the Influence of Subunit Packing and Charge on the Dissociation of Multiprotein Complexes

(2010) Elisabetta Boeri Erba et al.   ANALYTICAL CHEMISTRY

Alternate Dissociation Pathways Identified in Charge-Reduced Protein Complex Ions

(2010) Kevin Pagel et al.   ANALYTICAL CHEMISTRY

Recent advances in charting protein–protein interaction: mass spectrometry-based approaches

(2010) Anne-Claude Gavin et al.   CURRENT OPINION IN BIOTECHNOLOGY

Top-down mass spectrometry of supercharged native protein–ligand complexes

(2010) Sheng Yin et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

How far can we go with structural mass spectrometry of protein complexes?

(2010) Michal Sharon   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native Electrospray and Electron-Capture Dissociation in FTICR Mass Spectrometry Provide Top-Down Sequencing of a Protein Component in an Intact Protein Assembly

(2010) Hao Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Elucidating the site of protein-ATP binding by top-down mass spectrometry

(2010) Sheng Yin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Norwalk Virus Assembly and Stability Monitored by Mass Spectrometry

(2010) Glen K. Shoemaker et al.   MOLECULAR & CELLULAR PROTEOMICS

Physical basis of the inducer-dependent cooperativity of the Central glycolytic genes Repressor/DNA complex

(2010) D. Chaix et al.   NUCLEIC ACIDS RESEARCH

High-efficiency nano- and micro-HPLC - High-resolution Orbitrap-MS platform for top-down proteomics

(2010) Jens Mohr et al.   PROTEOMICS

Achievements and perspectives of top-down proteomics

(2010) Andrea Armirotti et al.   PROTEOMICS

Ion mobility mass spectrometry of proteins and proteinassemblies

(2009) Charlotte Uetrecht et al.   CHEMICAL SOCIETY REVIEWS

Native MS: an ’ESI‚ way to support structure- and fragment-based drug discovery

(2009) Valerie Vivat Hannah et al.   Future Medicinal Chemistry

An Integrative Approach Combining Noncovalent Mass Spectrometry, Enzyme Kinetics and X-ray Crystallography to Decipher Tgt Protein-Protein and Protein-RNA Interaction

(2009) Tina Ritschel et al.   JOURNAL OF MOLECULAR BIOLOGY

Probing the hydrophobic effect of noncovalent complexes by mass spectrometry

(2009) Claudia Bich et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

What does the future hold for top down mass spectrometry?

(2009) Benjamin A. Garcia   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Electrospray: From ions in solution to ions in the gas phase, what we know now

(2009) Paul Kebarle et al.   MASS SPECTROMETRY REVIEWS

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

(2009) Nelson P Barrera et al.   NATURE METHODS

Isoforms of U1-70k Control Subunit Dynamics in the Human Spliceosomal U1 snRNP

(2009) Helena Hernández et al.   PLoS One

An Atomistic View to the Gas Phase Proteome

(2009) Tim Meyer et al.   STRUCTURE

Symmetrical Modularity of the COP9 Signalosome Complex Suggests its Multifunctionality

(2009) Michal Sharon et al.   STRUCTURE

High-Resolution Mass Spectrometers

(2008) Alan G. Marshall et al.   Annual Review of Analytical Chemistry

Mapping of a copper-binding site on the small CP12 chloroplastic protein ofChlamydomonas reinhardtiiusing top-down mass spectrometry and site-directed mutagenesis

(2008) Jenny Erales et al.   BIOCHEMICAL JOURNAL

The use of ECD/ETD to identify the site of electrostatic interaction in noncovalent complexes

(2008) Shelley N. Jackson et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator fromBacillus subtilisreveal ligand-induced structural changes upon binding of several glycolytic intermediates

(2008) Pavlína Řezáčová et al.   MOLECULAR MICROBIOLOGY

Assembly reflects evolution of protein complexes

(2008) Emmanuel D. Levy et al.   NATURE

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS

Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3

(2008) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Micelles Protect Membrane Complexes from Solution to Vacuum

(2008) N. P. Barrera et al.   SCIENCE

Characterization of Platinum Anticancer Drug Protein-Binding Sites Using a Top-Down Mass Spectrometric Approach

(2007) Christian G. Hartinger et al.   INORGANIC CHEMISTRY