Journal
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume 23, Issue 6, Pages 1062-1070Publisher
AMER CHEMICAL SOC
DOI: 10.1007/s13361-012-0352-8
Keywords
Surface acoustic wave nebulization; Internal energy; Ionization method; ESI
Funding
- National Institutes of Health [1U54 AI57141-01]
- NSF [CHE-0342956, CHE-1055132]
- University of Washington
- CEA-Eurotalent [PCOFUND-GA-2008-228664]
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Surface acoustic wave nebulization (SAWN) has recently been reported as a novel method to transfer non-volatile analytes directly from solution to the gas phase for mass spectrometric analysis. Here we present a comparison of the survival yield of SAWN versus electrospray ionization (ESI) produced ions. A series of substituted benzylpyridinium (BzPy) compounds were utilized to measure ion survival yield from which ion energetics were inferred. We also estimated bond dissociation energies using higher level quantum chemical calculations than previously reported for BzPy ions. Additionally, the effects on BzPy precursor ion survival of SAWN operational parameters such as inlet capillary temperature and solution flow-rate were investigated. Under all conditions tested, SAWN-generated BzPy ions displayed a higher tendency for survival and thus have lower internal energies than those formed by ESI.
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