Structural significance of galectin design: impairment of homodimer stability by linker insertion and partial reversion by ligand presence

A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code

(2015) Dolores Solís et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Human chimera-type galectin-3: Defining the critical tail length for high-affinity glycoprotein/cell surface binding and functional competition with galectin-1 in neuroblastoma cell growth regulation

(2014) Jürgen Kopitz et al.   BIOCHIMIE

Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)

(2014) Sabine André et al.   CARBOHYDRATE RESEARCH

Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells

(2014) Federico M. Ruiz et al.   FEBS Journal

Impact of subunit linkages in an engineered homodimeric binding protein to  -synuclein

(2014) A. Gauhar et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target

(2013) Karel Smetana et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity

(2013) Elena Ermakova et al.   GLYCOBIOLOGY

Beyond glycoproteins as galectin counterreceptors: tumor-effector T cell growth control via ganglioside GM1

(2012) Robert W. Ledeen et al.   Annals of the New York Academy of Sciences

Analysis of homodimeric avian and human galectins by two methods based on fluorescence spectroscopy: Different structural alterations upon oxidation and ligand binding

(2012) Antonia Göhler et al.   BIOCHIMIE

X-ray structure of a protease-resistant mutant form of human galectin-8 with two carbohydrate recognition domains

(2012) Hiromi Yoshida et al.   FEBS Journal

Tumour suppressor p16INK4a- anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model

(2012) Maho Amano et al.   FEBS Journal

Ganglioside GM1/Galectin-Dependent Growth Regulation in Human Neuroblastoma Cells: Special Properties of Bivalent Galectin-4 and Significance of Linker Length for Ligand Selection

(2012) Jürgen Kopitz et al.   NEUROCHEMICAL RESEARCH

Linkers in the structural biology of protein-protein interactions

(2012) Vishnu Priyanka Reddy Chichili et al.   PROTEIN SCIENCE

Structural aspects of binding of α-linked digalactosides to human galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

Quantitative immunohistochemical fingerprinting of adhesion/growth-regulatory galectins in salivary gland tumours: divergent profiles with diagnostic potential

(2011) Myriam Remmelink et al.   HISTOPATHOLOGY

Galectin-1 and Galectin-8 Have Redundant Roles in Promoting Plasma Cell Formation

(2011) C.-M. Tsai et al.   JOURNAL OF IMMUNOLOGY

From lectin structure to functional glycomics: principles of the sugar code

(2011) Hans-Joachim Gabius et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hydrodynamic Properties of Human Adhesion/Growth-Regulatory Galectins Studied by Fluorescence Correlation Spectroscopy

(2010) Antonia Göhler et al.   BIOPHYSICAL JOURNAL

Galectin multimerization and lattice formation are regulated by linker region structure

(2010) L. A. Earl et al.   GLYCOBIOLOGY

How adhesion/growth-regulatory galectins-1 and -3 attain cell specificity: Case study defining their target on neuroblastoma cells (SK-N-MC) and marked affinity regulation by affecting microdomain organization of the membrane

(2010) Jürgen Kopitz et al.   IUBMB LIFE

Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity

(2010) Irina V. Nesmelova et al.   JOURNAL OF MOLECULAR BIOLOGY

Unique Chicken Tandem-Repeat-Type Galectin: Implications of Alternative Splicing and a Distinct Expression Profile Compared to Those of the Three Proto-Type Proteins

(2009) Herbert Kaltner et al.   BIOCHEMISTRY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 29 kDa human galectin-1 protein dimer

(2008) Irina V. Nesmelova et al.   Biomolecular NMR Assignments

Lgals6, a 2-Million-Year-Old Gene in Mice: A Case of Positive Darwinian Selection and Presence/Absence Polymorphism

(2008) D. Houzelstein et al.   GENETICS

Structural Features of Galectin-9 and Galectin-1 That Determine Distinct T Cell Death Pathways

(2008) Shuguang Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY