Augmented Replicative Capacity of the Boosting Antigen Improves the Protective Efficacy of Heterologous Prime-Boost Vaccine Regimens

Preexisting High Frequencies of Memory CD8+ T Cells Favor Rapid Memory Differentiation and Preservation of Proliferative Potential upon Boosting

(2013) Kathryn A. Fraser et al.   IMMUNITY

Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory

(2012) Travis A. Doering et al.   IMMUNITY

Alternative Serotype Adenovirus Vaccine Vectors Elicit Memory T Cells with Enhanced Anamnestic Capacity Compared to Ad5 Vectors

(2012) Pablo Penaloza-MacMaster et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Simian Immunodeficiency Virus Gag-Specific Effector and Memory CD8+T Cells Induced by Different Adenovirus Vectors

(2012) Wendy G. Tan et al.   JOURNAL OF VIROLOGY

Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys

(2012) Jeffrey E. Teigler et al.   JOURNAL OF VIROLOGY

Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection

(2012) J. M. Angelosanto et al.   JOURNAL OF VIROLOGY

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

(2012) Yoshinori Fukazawa et al.   NATURE MEDICINE

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load

(2011) Erin E. West et al.   IMMUNITY

Protective Capacity of Memory CD8+ T Cells Is Dictated by Antigen Exposure History and Nature of the Infection

(2011) Jeffrey C. Nolz et al.   IMMUNITY

4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection

(2011) V. Vezys et al.   JOURNAL OF IMMUNOLOGY

Opposing Effects of CD70 Costimulation during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection of Mice

(2011) P. Penaloza-MacMaster et al.   JOURNAL OF VIROLOGY

Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine

(2011) H. Qureshi et al.   JOURNAL OF VIROLOGY

Recombinant Adenovirus Serotype 26 (Ad26) and Ad35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates against Ebolavirus Challenge

(2011) T. W. Geisbert et al.   JOURNAL OF VIROLOGY

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine

(2011) Scott G. Hansen et al.   NATURE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Route of Adenovirus-Based HIV-1 Vaccine Delivery Impacts the Phenotype and Trafficking of Vaccine-Elicited CD8+ T Lymphocytes

(2010) D. R. Kaufman et al.   JOURNAL OF VIROLOGY

Enhancing therapeutic vaccination by blocking PD-1–mediated inhibitory signals during chronic infection

(2008) Sang-Jun Ha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus

(2008) M. Genesca et al.   JOURNAL OF VIROLOGY

HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case–cohort analysis

(2008) M Juliana McElrath et al.   LANCET

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

(2008) Jinyan Liu et al.   NATURE

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY