Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis

West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases

(2012) K. Roe et al.   JOURNAL OF GENERAL VIROLOGY

Erratum: Addendum: Defective Dock2 expression in a subset of ASC-deficient mouse lines

(2012) Sirish K Ippagunta et al.   NATURE IMMUNOLOGY

TLR2/MyD88/NF-κB Pathway, Reactive Oxygen Species, Potassium Efflux Activates NLRP3/ASC Inflammasome during Respiratory Syncytial Virus Infection

(2012) Jesus Segovia et al.   PLoS One

Effect of Serum Heat-Inactivation and Dilution on Detection of Anti-WNV Antibodies in Mice by West Nile Virus E-protein Microsphere Immunoassay

(2012) Madhuri Namekar et al.   PLoS One

Impaired Virus Clearance, Compromised Immune Response and Increased Mortality in Type 2 Diabetic Mice Infected with West Nile Virus

(2012) Mukesh Kumar et al.   PLoS One

Cell-intrinsic innate immune control of West Nile virus infection

(2012) Michael S. Diamond et al.   TRENDS IN IMMUNOLOGY

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome

(2011) Debra J. Taxman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenoprotein K Knockout Mice Exhibit Deficient Calcium Flux in Immune Cells and Impaired Immune Responses

(2011) S. Verma et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Detects Encephalomyocarditis Virus and Vesicular Stomatitis Virus Infection

(2011) J. V. Rajan et al.   JOURNAL OF VIROLOGY

Myxoma Virus Lacking the Pyrin-Like Protein M013 Is Sensed in Human Myeloid Cells by both NLRP3 and Multiple Toll-Like Receptors, Which Independently Activate the Inflammasome and NF- B Innate Response Pathways

(2011) M. M. Rahman et al.   JOURNAL OF VIROLOGY

Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59

(2011) A. H. Ellebedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of Legionella Pneumophila in Human Cells: Why are We Susceptible?

(2011) Arwa Abu Khweek et al.   Frontiers in Microbiology

Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes

(2010) S. Verma et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis

(2010) P. J. Shaw et al.   JOURNAL OF IMMUNOLOGY

Pro-inflammatory cytokines derived from West Nile virus (WNV)-infected SK-N-SH cells mediate neuroinflammatory markers and neuronal death

(2010) Mukesh Kumar et al.   Journal of Neuroinflammation

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

(2010) Erin McElvania TeKippe et al.   PLoS One

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Progress on the development of therapeutics against West Nile virus

(2009) Michael S. Diamond   ANTIVIRAL RESEARCH

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Expression and function of the NALP3 inflammasome in rheumatoid synovium

(2009) Laeticia Kolly et al.   IMMUNOLOGY

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain

(2009) N. B. Bryan et al.   JOURNAL OF IMMUNOLOGY

The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis

(2009) K. J. Szretter et al.   JOURNAL OF VIROLOGY

Neuronal and glial cerebrospinal fluid protein biomarkers are elevated after West Nile Virus infection

(2009) A. Petzold et al.   MUSCLE & NERVE

Reversal of West Nile virus-induced blood–brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor

(2009) Saguna Verma et al.   VIROLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection

(2008) Mikhail V Ovanesov et al.   Journal of Neuroinflammation

Tumor Necrosis Factor Alpha Protects against Lethal West Nile Virus Infection by Promoting Trafficking of Mononuclear Leukocytes into the Central Nervous System

(2008) B. Shrestha et al.   JOURNAL OF VIROLOGY

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE