Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into Macrophages

R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies

(2013) Lamorris M Loftin et al.   Journal of Translational Medicine

Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors

(2012) Paul J Peters et al.   Retrovirology

Multiple CCR5 Conformations on the Cell Surface Are Used Differentially by Human Immunodeficiency Viruses Resistant or Sensitive to CCR5 Inhibitors

(2011) R. Berro et al.   JOURNAL OF VIROLOGY

HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism

(2011) M. Roche et al.   JOURNAL OF VIROLOGY

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120–CD4 interactions and fusogenicity

(2011) Jasminka Sterjovski et al.   VIROLOGY

Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41

(2011) Cleo G. Anastassopoulou et al.   VIROLOGY

HIV Type 1 from a Patient with Baseline Resistance to CCR5 Antagonists Uses Drug-Bound Receptor for Entry

(2010) John C. Tilton et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5

(2010) John C. Tilton et al.   JOURNAL OF VIROLOGY

HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells

(2010) J. M. Pfaff et al.   JOURNAL OF VIROLOGY

A Conserved Determinant in the V1 Loop of HIV-1 Modulates the V3 Loop To Prime Low CD4 Use and Macrophage Infection

(2010) T. Musich et al.   JOURNAL OF VIROLOGY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5

(2010) Robert A. Ogert et al.   VIROLOGY

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

(2010) Jasminka Sterjovski et al.   VIROLOGY

Coreceptors and HIV-1 Pathogenesis

(2010) Paul R. Gorry et al.   Current HIV/AIDS Reports

Entry inhibitors in the treatment of HIV-1 infection

(2009) John C. Tilton et al.   ANTIVIRAL RESEARCH

Entry Coreceptor Use and Fusion Inhibitor T20 Sensitivity of Dual-Tropic R5X4 HIV-1 in Primary Macrophage Infection

(2009) Yanjie Yi et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

(2009) L. Gray et al.   JOURNAL OF VIROLOGY

Structure-Function Analysis of Human Immunodeficiency Virus Type 1 gp120 Amino Acid Mutations Associated with Resistance to the CCR5 Coreceptor Antagonist Vicriviroc

(2009) R. A. Ogert et al.   JOURNAL OF VIROLOGY

Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 Envelopes

(2009) M. J. Duenas-Decamp et al.   JOURNAL OF VIROLOGY

Heterosexual Transmission of Human Immunodeficiency Virus Type 1 Subtype C: Macrophage Tropism, Alternative Coreceptor Use, and the Molecular Anatomy of CCR5 Utilization

(2009) J. Isaacman-Beck et al.   JOURNAL OF VIROLOGY

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41

(2009) C. G. Anastassopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

(2009) M. Pancera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12

(2009) Rebecca L Dunfee et al.   Retrovirology

Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

(2009) Reem Berro et al.   PLoS Pathogens

Only Five of 10 Strictly Conserved Disulfide Bonds Are Essential for Folding and Eight for Function of the HIV-1 Envelope Glycoprotein

(2008) Eelco van Anken et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE