HIV-1 Escape from the CCR5 Antagonist Maraviroc Associated with an Altered and Less-Efficient Mechanism of gp120-CCR5 Engagement That Attenuates Macrophage Tropism

CCR5 antibodies HGS004 and HGS101 preferentially inhibit drug-bound CCR5 infection and restore drug sensitivity of Maraviroc-resistant HIV-1 in primary cells

(2011) Olga Latinovic et al.   VIROLOGY

CD4-binding site alterations in CCR5-using HIV-1 envelopes influencing gp120–CD4 interactions and fusogenicity

(2011) Jasminka Sterjovski et al.   VIROLOGY

Population-based V3 genotypic tropism assay: a retrospective analysis using screening samples from the A4001029 and MOTIVATE studies

(2010) Rachel A McGovern et al.   AIDS

HIV Type 1 from a Patient with Baseline Resistance to CCR5 Antagonists Uses Drug-Bound Receptor for Entry

(2010) John C. Tilton et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus Envelope Glycoprotein Trimer

(2010) S.-H. Xiang et al.   JOURNAL OF VIROLOGY

A Maraviroc-Resistant HIV-1 with Narrow Cross-Resistance to Other CCR5 Antagonists Depends on both N-Terminal and Extracellular Loop Domains of Drug-Bound CCR5

(2010) John C. Tilton et al.   JOURNAL OF VIROLOGY

HIV-1 Resistance to CCR5 Antagonists Associated with Highly Efficient Use of CCR5 and Altered Tropism on Primary CD4+ T Cells

(2010) J. M. Pfaff et al.   JOURNAL OF VIROLOGY

Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5

(2010) Robert A. Ogert et al.   VIROLOGY

An altered and more efficient mechanism of CCR5 engagement contributes to macrophage tropism of CCR5-using HIV-1 envelopes

(2010) Jasminka Sterjovski et al.   VIROLOGY

Coreceptors and HIV-1 Pathogenesis

(2010) Paul R. Gorry et al.   Current HIV/AIDS Reports

Broad usage spectrum of G protein-coupled receptors as coreceptors by primary isolates of HIV

(2009) Nobuaki Shimizu et al.   AIDS

Entry inhibitors in the treatment of HIV-1 infection

(2009) John C. Tilton et al.   ANTIVIRAL RESEARCH

Tissue-Specific Sequence Alterations in the Human Immunodeficiency Virus Type 1 Envelope Favoring CCR5 Usage Contribute to Persistence of Dual-Tropic Virus in the Brain

(2009) L. Gray et al.   JOURNAL OF VIROLOGY

Structure-Function Analysis of Human Immunodeficiency Virus Type 1 gp120 Amino Acid Mutations Associated with Resistance to the CCR5 Coreceptor Antagonist Vicriviroc

(2009) R. A. Ogert et al.   JOURNAL OF VIROLOGY

Determinants Flanking the CD4 Binding Loop Modulate Macrophage Tropism of Human Immunodeficiency Virus Type 1 R5 Envelopes

(2009) M. J. Duenas-Decamp et al.   JOURNAL OF VIROLOGY

A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains

(2009) Samantha. H. Johnston et al.   JOURNAL OF VIROLOGY

Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41

(2009) C. G. Anastassopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12

(2009) Rebecca L Dunfee et al.   Retrovirology

Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

(2009) Pavel Pugach et al.   VIROLOGY

Enhanced CD4+ cellular apoptosis by CCR5-restricted HIV-1 envelope glycoprotein variants from patients with progressive HIV-1 infection

(2009) Jessica Wade et al.   VIROLOGY

Two HIV-1 Variants Resistant to Small Molecule CCR5 Inhibitors Differ in How They Use CCR5 for Entry

(2009) Reem Berro et al.   PLoS Pathogens

Virologic Failure in Therapy-Naive Subjects on Aplaviroc plus Lopinavir-Ritonavir: Detection of Aplaviroc Resistance Requires Clonal Analysis of Envelope

(2008) K. M. Kitrinos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Involvement of the Second Extracellular Loop and Transmembrane Residues of CCR5 in Inhibitor Binding and HIV-1 Fusion: Insights into the Mechanism of Allosteric Inhibition

(2008) Kenji Maeda et al.   JOURNAL OF MOLECULAR BIOLOGY