Children's Oncology Group's 2013 blueprint for research: Bone tumors

Randomized comparison of every-two-week v. every-three-week chemotherapy in Ewing sarcoma family tumors (ESFT)

(2017) R. B. Womer et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts

(2015) Toru Akiyama et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Ecteinascidin 743 Interferes with the Activity of EWS-FLI1 in Ewing Sarcoma Cells

(2015) Patrick J. Grohar et al.   NEOPLASIA

Epigenetic Changes in Pediatric Solid Tumors: Promising New Targets

(2012) E. R. Lawlor et al.   CLINICAL CANCER RESEARCH

Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells

(2012) Alexander G. Beristain et al.   JOURNAL OF CELL SCIENCE

Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group

(2012) David Ebb et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Controlled Trial of Interval-Compressed Chemotherapy for the Treatment of Localized Ewing Sarcoma: A Report From the Children's Oncology Group

(2012) Richard B. Womer et al.   JOURNAL OF CLINICAL ONCOLOGY

Common Musculoskeletal Tumors of Childhood and Adolescence

(2012) Carola A.S. Arndt et al.   MAYO CLINIC PROCEEDINGS

A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion

(2012) Gaëlle Pierron et al.   NATURE GENETICS

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Molecular Pathogenesis of Ewing Sarcoma: New Therapeutic and Transcriptional Targets

(2011) Stephen L. Lessnick et al.   Annual Review of Pathology-Mechanisms of Disease

Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma

(2011) Scott C. Borinstein et al.   CANCER

Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription

(2011) M. Patel et al.   GENOME RESEARCH

Dipeptidyl Peptidases as Survival Factors in Ewing Sarcoma Family of Tumors

(2011) Congyi Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R1507, a Monoclonal Antibody to the Insulin-Like Growth Factor 1 Receptor, in Patients With Recurrent or Refractory Ewing Sarcoma Family of Tumors: Results of a Phase II Sarcoma Alliance for Research Through Collaboration Study

(2011) Alberto S. Pappo et al.   JOURNAL OF CLINICAL ONCOLOGY

Preliminary Efficacy of the Anti-Insulin–Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma

(2011) Heribert Juergens et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening

(2011) Patrick J. Grohar et al.   JNCI-Journal of the National Cancer Institute

Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling

(2011) C Garofalo et al.   ONCOGENE

R1507, an Anti-Insulin-Like Growth Factor-1 Receptor (IGF-1R) Antibody, and EWS/FLI-1 siRNA in Ewing's Sarcoma: Convergence at the IGF/IGFR/Akt Axis

(2011) Helen J. Huang et al.   PLoS One

Promiscuous partnerships in Ewing's sarcoma

(2011) Savita Sankar et al.   Cancer Genetics

Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors

(2010) Yan Li et al.   CANCER LETTERS

A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

(2010) Jeffrey D. Hancock et al.   CELL CYCLE

RANK-Fc inhibits malignancy via inhibiting ERK activation and evoking caspase-3-mediated anoikis in human osteosarcoma cells

(2010) Toru Akiyama et al.   CLINICAL & EXPERIMENTAL METASTASIS

Ewing Tumors That Do Not Overexpress BMI-1 Are a Distinct Molecular Subclass with Variant Biology: A Report from the Children's Oncology Group

(2010) A. Cooper et al.   CLINICAL CANCER RESEARCH

A Phase I Study of Weekly R1507, A Human Monoclonal Antibody Insulin-like Growth Factor-I Receptor Antagonist, in Patients with Advanced Solid Tumors

(2010) R. Kurzrock et al.   CLINICAL CANCER RESEARCH

Inhaled Granulocyte-Macrophage Colony Stimulating Factor for First Pulmonary Recurrence of Osteosarcoma: Effects on Disease-Free Survival and Immunomodulation. A Report From the Children's Oncology Group

(2010) C. A. S. Arndt et al.   CLINICAL CANCER RESEARCH

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

(2010) Sam D. Molyneux et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact ofEWS-ETSFusion Type on Disease Progression in Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: Prospective Results From the Cooperative Euro-E.W.I.N.G. 99 Trial

(2010) Marie-Cecile Le Deley et al.   JOURNAL OF CLINICAL ONCOLOGY

Current Treatment Protocols Have Eliminated the Prognostic Advantage of Type 1 Fusions in Ewing Sarcoma: A Report From the Children's Oncology Group

(2010) John A. van Doorninck et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma

(2010) Alice L. Yu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recent advances in the molecular pathogenesis of Ewing's sarcoma

(2010) E C Toomey et al.   ONCOGENE

Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program

(2010) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Downstream EWS/FLI1 - upstream Ewing's sarcoma

(2010) Heinrich Kovar   Genome Medicine

Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

(2009) D Herrero-Martín et al.   BRITISH JOURNAL OF CANCER

Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma

(2009) Alexander J. Chou et al.   CANCER

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

The Insulin-like Growth Factor-1 Receptor-Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma

(2009) R. T. Kurmasheva et al.   CANCER RESEARCH

EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma

(2009) M. Kinsey et al.   CANCER RESEARCH

Ewing’s Sarcoma: Standard and Experimental Treatment Options

(2009) Vivek Subbiah et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons

(2009) Lisa Mirabello et al.   INTERNATIONAL JOURNAL OF CANCER

GLI1 Is a Direct Transcriptional Target of EWS-FLI1 Oncoprotein

(2009) Elspeth Beauchamp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

(2009) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study

(2009) David Olmos et al.   LANCET ONCOLOGY

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance

(2009) W Luo et al.   ONCOGENE

The Role of IGF-1R in Pediatric Malignancies

(2009) S. Y. Kim et al.   ONCOLOGIST

Irinotecan and temozolomide for Ewing sarcoma: The Memorial Sloan-Kettering experience

(2009) Denise A. Casey et al.   PEDIATRIC BLOOD & CANCER

Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow

(2009) Steven G. DuBois et al.   PEDIATRIC BLOOD & CANCER

EWS-FLI1 Suppresses NOTCH-Activated p53 in Ewing's Sarcoma

(2008) J. Ban et al.   CANCER RESEARCH

The Mechanisms of Differential Sensitivity to an Insulin-like Growth Factor-1 Receptor Inhibitor (BMS-536924) and Rationale for Combining with EGFR/HER2 Inhibitors

(2008) F. Huang et al.   CANCER RESEARCH

High Expression of Neuropeptide Y1 Receptors in Ewing Sarcoma Tumors

(2008) M. Korner et al.   CLINICAL CANCER RESEARCH

Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group

(2008) Paul A. Meyers et al.   JOURNAL OF CLINICAL ONCOLOGY

Changes in Incidence and Survival of Ewing Sarcoma Patients Over the Past 3 Decades

(2008) Natia Esiashvili et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Therapeutic efficacy of soluble receptor activator of nuclear factor-κB-Fc delivered by nonviral gene transfer in a mouse model of osteolytic osteosarcoma

(2008) François Lamoureux et al.   MOLECULAR CANCER THERAPEUTICS

Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

(2008) E. Anders Kolb et al.   PEDIATRIC BLOOD & CANCER

Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: A report from the Children's Oncology Group

(2008) Steven G. DuBois et al.   PEDIATRIC BLOOD & CANCER

EWS/FLI Mediates Transcriptional Repression via NKX2.2 during Oncogenic Transformation in Ewing's Sarcoma

(2008) Leah A. Owen et al.   PLoS One

IGF1 Is a Common Target Gene of Ewing's Sarcoma Fusion Proteins in Mesenchymal Progenitor Cells

(2008) Luisa Cironi et al.   PLoS One

Microsatellites as EWS/FLI response elements in Ewing's sarcoma

(2008) K. Gangwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA