Autoinhibition of MDMX by intramolecular p53 mimicry

Autoactivation of the MDM2 E3 Ligase by Intramolecular Interaction

(2014) Q. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MDMX contains an autoinhibitory sequence element

(2013) M. Bista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

Abstract 4074: Prostaglandin E2 promotes intestinal tumor growth via DNA methylation

(2012) Dianren Xia et al.   CANCER RESEARCH

Casein Kinase 1  Regulates an MDMX Intramolecular Interaction To Stimulate p53 Binding

(2012) S. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

(2012) B. Graves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal MDMX degradation in tumor cells due to ARF deficiency

(2011) X Li et al.   ONCOGENE

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

(2010) Baozong Li et al.   CELL CYCLE

MDM4 binds ligands via a mechanism in which disordered regions become structured

(2010) Maria C. Sanchez et al.   FEBS LETTERS

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX

(2009) Jason Phan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION