Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Published 2012 View Full Article
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Title
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 29, Pages 11788-11793
Publisher
Proceedings of the National Academy of Sciences
Online
2012-06-29
DOI
10.1073/pnas.1203789109
References
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Note: Only part of the references are listed.- Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
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- (2011) L. Huang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53
- (2010) Federico Bernal et al. CANCER CELL
- Identification and Characterization of the First Small Molecule Inhibitor of MDMX
- (2010) Damon Reed et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Medicinal Chemist’s Guide to Molecular Interactions
- (2010) Caterina Bissantz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Role of Mdm4 in drug sensitivity of breast cancer cells
- (2010) S Lam et al. ONCOGENE
- The p53 orchestra: Mdm2 and Mdmx set the tone
- (2010) Mark Wade et al. TRENDS IN CELL BIOLOGY
- Mdm2-mediated ubiquitylation: p53 and beyond
- (2009) J-C Marine et al. CELL DEATH AND DIFFERENTIATION
- Inhibitors of MDM2 and MDMX: a structural perspective
- (2009) Christiane Riedinger et al. Future Medicinal Chemistry
- Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
- (2009) Joerg Kallen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Potent and Orally Active Small-Molecule Inhibitors of the MDM2−p53 Interaction
- (2009) Shanghai Yu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
- (2009) Mark Wade et al. MOLECULAR CANCER RESEARCH
- Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
- (2009) M. Pazgier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans
- (2008) K Linke et al. CELL DEATH AND DIFFERENTIATION
- Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
- (2008) S. Shangary et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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