Abnormal MDMX degradation in tumor cells due to ARF deficiency

Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation

(2011) Mingxuan Xia et al.   CELL CYCLE

Small-Molecule Inhibitors of p53-MDM2 Interaction: the 2006-2010 Update

(2011) Melissa Millard et al.   CURRENT PHARMACEUTICAL DESIGN

Inhibition of p53 DNA Binding Function by the MDM2 Protein Acidic Domain

(2011) Brittany Cross et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Spontaneous Tumorigenesis in Mice Overexpressing the p53-Negative Regulator Mdm4

(2010) S. Xiong et al.   CANCER RESEARCH

p53 inactivation by MDM2 and MDMX negative feedback loops in testicular germ cell tumors

(2010) Baozong Li et al.   CELL CYCLE

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of theHDMXGene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

(2010) Anna Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

(2010) Delin Chen et al.   NATURE

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

ATM activates p53 by regulating MDM2 oligomerization and E3 processivity

(2009) Qian Cheng et al.   EMBO JOURNAL

Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans

(2008) K Linke et al.   CELL DEATH AND DIFFERENTIATION

Intrinsically Unstructured Domains of Arf and Hdm2 Form Bimolecular Oligomeric Structures In Vitro and In Vivo

(2008) Sivashankar G. Sivakolundu et al.   JOURNAL OF MOLECULAR BIOLOGY

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA