PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21
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Title
PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21
Authors
Keywords
Medical hypoxia, Mouse models, RNA extraction, Small interfering RNAs, Transfection, Hypoxia, MicroRNAs, Pathogenesis
Journal
PLoS One
Volume 10, Issue 7, Pages e0133391
Publisher
Public Library of Science (PLoS)
Online
2015-07-25
DOI
10.1371/journal.pone.0133391
References
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Related references
Note: Only part of the references are listed.- MicroRNAs in Pulmonary Arterial Hypertension
- (2015) Guofei Zhou et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension
- (2014) Thomas Bertero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of PPAR-γ ameliorates pulmonary arterial hypertension via inducing heme oxygenase-1 and p21WAF1: An in vivo study in rats
- (2014) Dexin Zhang et al. LIFE SCIENCES
- Is Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) a Therapeutic Target for the Treatment of Pulmonary Hypertension?
- (2014) David E. Green et al. Pulmonary Circulation
- Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells
- (2013) Xianghuai Lu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Hypoxia Mediates Mutual Repression between microRNA-27a and PPARγ in the Pulmonary Vasculature
- (2013) Bum-Yong Kang et al. PLoS One
- Critical Role for the Advanced Glycation End‐Products Receptor in Pulmonary Arterial Hypertension Etiology
- (2013) Jolyane Meloche et al. Journal of the American Heart Association
- Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension
- (2013) Henrick Horita et al. Journal of the American Heart Association
- miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
- (2012) Shanzhong Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation
- (2012) David E. Green et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension
- (2012) Victoria N. Parikh et al. CIRCULATION
- A Role for miR-145 in Pulmonary Arterial Hypertension
- (2012) Paola Caruso et al. CIRCULATION RESEARCH
- Peroxisome Proliferator-Activated Receptor-γ Ameliorates Pulmonary Arterial Hypertension by Inhibiting 5-Hydroxytryptamine 2B Receptor
- (2012) Yahan Liu et al. HYPERTENSION
- Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression
- (2012) Clemens L. Bockmeyer et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- BMP-2 Up-Regulates PTEN Expression and Induces Apoptosis of Pulmonary Artery Smooth Muscle Cells under Hypoxia
- (2012) Weifeng Pi et al. PLoS One
- The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study
- (2012) L. Azoulay et al. BMJ-British Medical Journal
- Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Regulates Thrombospondin-1 and Nox4 Expression in Hypoxia-Induced Human Pulmonary Artery Smooth Muscle Cell Proliferation
- (2012) David E. Green et al. Pulmonary Circulation
- Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension
- (2012) Kevin White et al. Pulmonary Circulation
- The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
- (2011) Bum-Yong Kang et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Hypoxia induces downregulation of PPAR-γ in isolated pulmonary arterial smooth muscle cells and in rat lung via transforming growth factor-β signaling
- (2011) Kaizheng Gong et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Inhibition of MicroRNA-17 Improves Lung and Heart Function in Experimental Pulmonary Hypertension
- (2011) Soni S. Pullamsetti et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Akt2 Regulates All Akt Isoforms and Promotes Resistance to Hypoxia through Induction of miR-21 upon Oxygen Deprivation
- (2011) C. Polytarchou et al. CANCER RESEARCH
- Dysregulation of PTEN in Cardiopulmonary Vascular Remodeling Induced by Pulmonary Hypertension
- (2011) Yazhini Ravi et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
- (2011) Tero-Pekka Alastalo et al. JOURNAL OF CLINICAL INVESTIGATION
- Role for miR-204 in human pulmonary arterial hypertension
- (2011) Audrey Courboulin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Peroxisome Proliferator-Activated Receptor γ Agonist Troglitazone Inhibits High Mobility Group Box 1 Expression in Endothelial Cells Via Suppressing Transcriptional Activity of Nuclear Factor κB and Activator Protein 1
- (2011) Min Gao et al. SHOCK
- MicroRNAs-Control of Essential Genes: Implications for Pulmonary Vascular Disease
- (2011) Sachindra R. Joshi et al. Pulmonary Circulation
- PPARγ regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-κB
- (2010) Xianghuai Lu et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration
- (2010) Joy Sarkar et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity
- (2010) Martina Weber et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Basic Science of Pulmonary Arterial Hypertension for Clinicians
- (2010) Stephen L. Archer et al. CIRCULATION
- miRNAs: roles and clinical applications in vascular disease
- (2010) Md Saha Jamaluddin et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
- (2010) Gang Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- miR-130 Suppresses Adipogenesis by Inhibiting Peroxisome Proliferator-Activated Receptor Expression
- (2010) E. K. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- Emerging therapies for the treatment of pulmonary hypertension
- (2010) Kurt R. Stenmark et al. Pediatric Critical Care Medicine
- Rosiglitazone attenuates hypoxia-induced pulmonary arterial hypertension in rats
- (2010) Eun Kyung KIM et al. RESPIROLOGY
- PPARγ as a potential therapeutic target in pulmonary hypertension
- (2010) Roy L. Sutliff et al. Therapeutic Advances in Respiratory Disease
- Rosiglitazone Attenuates Chronic Hypoxia–Induced Pulmonary Hypertension in a Mouse Model
- (2009) Rachel E. Nisbet et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
- (2009) Michael Karbiener et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway
- (2009) Matthias Brock et al. CIRCULATION RESEARCH
- MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4
- (2009) Yunhui Cheng et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Effect of PPARγ inhibition on pulmonary endothelial cell gene expression: gene profiling in pulmonary hypertension
- (2009) Jing Tian et al. PHYSIOLOGICAL GENOMICS
- Molecular pathogenesis of pulmonary arterial hypertension
- (2008) Marlene Rabinovitch JOURNAL OF CLINICAL INVESTIGATION
- An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension
- (2008) Georg Hansmann et al. JOURNAL OF CLINICAL INVESTIGATION
- miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism
- (2008) Shuji Fujita et al. JOURNAL OF MOLECULAR BIOLOGY
- SMAD proteins control DROSHA-mediated microRNA maturation
- (2008) Brandi N. Davis et al. NATURE
- Understanding PTEN regulation: PIP2, polarity and protein stability
- (2008) N R Leslie et al. ONCOGENE
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