Damaging the Integrated HIV Proviral DNA with TALENs

Construction and characterization of adenoviral vectors for the delivery of TALENs into human cells

(2014) Maarten Holkers et al.   METHODS

Cell-Penetrating Peptide-Mediated Delivery of TALEN Proteins via Bioconjugation for Genome Engineering

(2014) Jia Liu et al.   PLoS One

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From reactivation of latent HIV-1 to elimination of the latent reservoir: The presence of multiple barriers to viral eradication

(2013) Liang Shan et al.   BIOESSAYS

A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models

(2013) Stefan Frank et al.   BMC GENOMICS

Gene therapy for PIDs: Progress, pitfalls and prospects

(2013) Sayandip Mukherjee et al.   GENE

Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART

(2013) C W Peterson et al.   GENE THERAPY

TALEN or Cas9 – Rapid, Efficient and Specific Choices for Genome Modifications

(2013) Chuanxian Wei et al.   Journal of Genetics and Genomics

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

(2013) Kristie Bloom et al.   MOLECULAR THERAPY

TALENs Targeting HBV: Designer Endonuclease Therapies for Viral Infections

(2013) Nicholas D Weber et al.   MOLECULAR THERAPY

Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients

(2013) David G Ousterout et al.   MOLECULAR THERAPY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polµ and Polλ

(2013) Maria Jose Martin et al.   NUCLEIC ACIDS RESEARCH

Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells

(2013) Haibao Zhu et al.   NUCLEIC ACIDS RESEARCH

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

(2013) Xiying Qu et al.   NUCLEIC ACIDS RESEARCH

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

(2013) Shijia Chen et al.   NUCLEIC ACIDS RESEARCH

High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases

(2013) Zhongwei Qiu et al.   NUCLEIC ACIDS RESEARCH

High Efficiency In Vivo Genome Engineering with a Simplified 15-RVD GoldyTALEN Design

(2013) Alvin C. Ma et al.   PLoS One

Efficient TALEN Construction for Bombyx mori Gene Targeting

(2013) Yoko Takasu et al.   PLoS One

Targeted Gene Therapy of Xeroderma Pigmentosum Cells Using Meganuclease and TALEN™

(2013) Aurélie Dupuy et al.   PLoS One

The CRISPR Craze

(2013) E. Pennisi   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Targeted gene disruption to cure HIV

(2013) Daniel Stone et al.   Current Opinion in HIV and AIDS

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

(2013) Hirotaka Ebina et al.   Scientific Reports

Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity

(2013) Tetsushi Sakuma et al.   Scientific Reports

Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila

(2013) Kelly J. Beumer et al.   G3-Genes Genomes Genetics

Highly Significant Antiviral Activity of HIV-1 LTR-Specific Tre-Recombinase in Humanized Mice

(2013) Ilona Hauber et al.   PLoS Pathogens

Comparison of TALEN scaffolds in Xenopus tropicalis

(2013) K. Nakajima et al.   Biology Open

As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs

(2012) Alex Sigal et al.   Cell Host & Microbe

Viral latency and potential eradication of HIV-1

(2012) Kenneth A Matreyek et al.   Expert Review of Anti-Infective Therapy

Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

(2012) Julien Valton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy

(2012) Jiyong Liu et al.   Journal of Genetics and Genomics

Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections

(2012) J. T. Schiffer et al.   JOURNAL OF VIROLOGY

Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease

(2012) Ning Sun et al.   Molecular BioSystems

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

(2012) Thomas Gaj et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

DNA expansions generated by human Polµ on iterative sequences

(2012) Ana Aza et al.   NUCLEIC ACIDS RESEARCH

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

(2012) Lindsay Cade et al.   NUCLEIC ACIDS RESEARCH

Excision of HIV-1 Proviral DNA by Recombinant Cell Permeable Tre-Recombinase

(2012) Lakshmikanth Mariyanna et al.   PLoS One

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates

(2011) Romain Chayot et al.   DNA REPAIR

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells

(2011) Maarten Holkers et al.   NUCLEIC ACIDS RESEARCH

Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

(2011) Martine Aubert et al.   PLoS One

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

(2011) M. M. Mahfouz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

(2010) Tae-Wook Chun et al.   AIDS

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Review of the clinical development of alipogene tiparvovec gene therapy for lipoprotein lipase deficiency

(2010) Daniel Gaudet et al.   ATHEROSCLEROSIS SUPPLEMENTS

Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication

(2010) M. E. Abram et al.   JOURNAL OF VIROLOGY

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

(2010) Yannick Doyon et al.   NATURE METHODS

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

(2010) J. D. Sander et al.   NUCLEIC ACIDS RESEARCH

TAL effector-DNA specificity

(2010) Heidi Scholze et al.   Virulence

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE