Targeted DNA Mutagenesis for the Cure of Chronic Viral Infections

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

(2012) Hans-Peter Kiem et al.   Cell Stem Cell

HIV-1 DNA Is Detected in Bone Marrow Populations Containing CD4+ T Cells but Is not Found in Purified CD34+ Hematopoietic Progenitor Cells in Most Patients on Antiretroviral Therapy

(2012) Christine M. Durand et al.   JOURNAL OF INFECTIOUS DISEASES

Hematopoietic Precursor Cells Isolated From Patients on Long-term Suppressive HIV Therapy Did Not Contain HIV-1 DNA

(2012) Lina Josefsson et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells

(2011) Christoph C. Carter et al.   Cell Host & Microbe

Virological breakthrough and resistance in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice

(2011) Chanunta Hongthanakorn et al.   HEPATOLOGY

Zinc-Finger Nucleases for Somatic Gene Therapy: The Next Frontier

(2011) Shamim H. Rahman et al.   HUMAN GENE THERAPY

Chimeric mouse model of hepatitis B virus infection

(2011) Maura Dandri et al.   JOURNAL OF HEPATOLOGY

The Kinetics of Mucosal Herpes Simplex Virus–2 Infection in Humans: Evidence for Rapid Viral-Host Interactions

(2011) Joshua T. Schiffer et al.   JOURNAL OF INFECTIOUS DISEASES

Meganuclease-mediated Inhibition of HSV1 Infection in Cultured Cells

(2011) Stéphanie Grosse et al.   MOLECULAR THERAPY

Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood–brain barrier

(2011) Giovanni Tosi et al.   Nanomedicine

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy

(2011) Alex Sigal et al.   NATURE

Gene editing: not just for translation anymore

(2011) Moira A McMahon et al.   NATURE METHODS

Ex vivo gene transfer and correction for cell-based therapies

(2011) Luigi Naldini   NATURE REVIEWS GENETICS

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering

(2011) Umut Y. Ulge et al.   NUCLEIC ACIDS RESEARCH

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

(2011) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI

(2011) Martine Aubert et al.   PLoS One

Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule

(2011) L. Josefsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Critical Subset Model Provides a Conceptual Basis for the High Antiviral Activity of Major HIV Drugs

(2011) L. Shen et al.   Science Translational Medicine

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

(2011) Barry L. Stoddard   STRUCTURE

Identity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursors

(2011) Misaki Wayengera   Theoretical Biology and Medical Modelling

Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases

(2011) Craig B. Wilen et al.   PLoS Pathogens

Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV

(2010) Jacqueline Neuhaus et al.   AIDS

The effect of transmitted HIV-1 drug resistance on pre-therapy viral load

(2010) Linda Harrison et al.   AIDS

Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication

(2010) Tae-Wook Chun et al.   AIDS

Short Communication: Dynamic Constraints on the Second Phase Compartment of HIV-Infected Cells

(2010) Adam M. Spivak et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Molecular genetics of HBV infection

(2010) Stephen Locarnini et al.   ANTIVIRAL THERAPY

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

TAL effectors: finding plant genes for disease and defense

(2010) Adam J Bogdanove et al.   CURRENT OPINION IN PLANT BIOLOGY

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Detection of Hepatitis B and C Viruses in Almost All Hepatocytes by Modified PCR-Based In Situ Hybridization

(2010) H. Nuriya et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction

(2010) Min Liang et al.   JOURNAL OF GENE MEDICINE

Persistent Genital Herpes Simplex Virus-2 Shedding Years Following the First Clinical Episode

(2010) Warren Phipps et al.   JOURNAL OF INFECTIOUS DISEASES

Sequence Variability in Clinical and Laboratory Isolates of Herpes Simplex Virus 1 Reveals New Mutations

(2010) M. L. Szpara et al.   JOURNAL OF VIROLOGY

Spread of Herpes Simplex Virus to the Spinal Cord Is Independent of Spread to Dorsal Root Ganglia

(2010) M. Ohashi et al.   JOURNAL OF VIROLOGY

Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication

(2010) M. E. Abram et al.   JOURNAL OF VIROLOGY

In vitro evolution and analysis of HIV-1 LTR-specific recombinases

(2010) Frank Buchholz et al.   METHODS

Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs

(2010) Thomas J Cradick et al.   MOLECULAR THERAPY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

Genome editing with engineered zinc finger nucleases

(2010) Fyodor D. Urnov et al.   NATURE REVIEWS GENETICS

Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases

(2010) Ankit Gupta et al.   NUCLEIC ACIDS RESEARCH

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

(2010) Justin Ashworth et al.   NUCLEIC ACIDS RESEARCH

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

(2010) Ting Li et al.   NUCLEIC ACIDS RESEARCH

Painful Failure of Promising Genital Herpes Vaccine

(2010) J. Cohen   SCIENCE

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Rapid Emergence of Protease Inhibitor Resistance in Hepatitis C Virus

(2010) L. Rong et al.   Science Translational Medicine

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

Simian immunodeficiency virus macaque models of HIV latency

(2010) Jesse D Deere et al.   Current Opinion in HIV and AIDS

The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial

(2010) Rajesh T. Gandhi et al.   PLOS MEDICINE

Generation of Covalently Closed Circular DNA of Hepatitis B Viruses via Intracellular Recycling Is Regulated in a Virus Specific Manner

(2010) Josef Köck et al.   PLoS Pathogens

Increased mutations in Env and Pol suggest greater HIV-1 replication in sputum-derived viruses compared with blood-derived viruses

(2009) Thor A Wagner et al.   AIDS

The “Trojan horse” model-delivery of anti-HBV small interfering RNAs by a recombinant HBV vector

(2009) Amir Shlomai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatitis B Virus Reactivation following Allogeneic Hematopoietic Stem Cell Transplantation

(2009) Sarah P. Hammond et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model

(2009) S. Shimizu et al.   BLOOD

Specific Transduction of HIV-Susceptible Cells for CCR5 Knockdown and Resistance to HIV Infection: A Novel Method for Targeted Gene Therapy and Intracellular Immunization

(2009) Joseph S Anderson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Asymptomatically shed recombinant herpes simplex virus type 1 strains detected in saliva

(2009) J. A. Liljeqvist et al.   JOURNAL OF GENERAL VIROLOGY

CCR5 Deficiency Is a Risk Factor for Early Clinical Manifestations of West Nile Virus Infection but not for Viral Transmission

(2009) Jean K. Lim et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4+ T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy

(2009) T. P. Brennan et al.   JOURNAL OF VIROLOGY

Hepatitis B virus infection

(2009) Yun-Fan Liaw et al.   LANCET

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Persistence of HIV-1 receptor–positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

(2009) Jia Zhu et al.   NATURE MEDICINE

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compartmentalization of HIV-1 within the Female Genital Tract Is Due to Monotypic and Low-Diversity Variants Not Distinct Viral Populations

(2009) Marta Bull et al.   PLoS One

Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy

(2009) J. B. Dinoso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy

(2009) Libin Rong et al.   PLoS Computational Biology

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

New concepts in understanding genital herpes

(2009) Joshua T. Schiffer et al.   Current Infectious Disease Reports

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

The role of the DNA damage response in neuronal development, organization and maintenance

(2008) Ari Barzilai et al.   DNA REPAIR

Modeling complex decay profiles of hepatitis B virus during antiviral therapy

(2008) Harel Dahari et al.   HEPATOLOGY

Efficient Inhibition of Hepatitis B Virus Replication In Vivo, Using Polyethylene Glycol-Modified Adenovirus Vectors

(2008) Carol Crowther et al.   HUMAN GENE THERAPY

Exploring gene-deleted adenoviral vectors for delivery of short hairpin RNAs and reduction of hepatitis B virus infection in mice

(2008) Christina Rauschhuber et al.   JOURNAL OF GENE MEDICINE

Supragenotypic groups of the hepatitis B virus genome

(2008) M. A. Purdy et al.   JOURNAL OF GENERAL VIROLOGY

Relapse of hepatitis B in HBeAg-negative chronic hepatitis B patients who discontinued successful entecavir treatment: The case for continuous antiviral therapy

(2008) Daniel Shouval et al.   JOURNAL OF HEPATOLOGY

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

Zinc Finger Proteins Designed To Specifically Target Duck Hepatitis B Virus Covalently Closed Circular DNA Inhibit Viral Transcription in Tissue Culture

(2008) K. A. Zimmerman et al.   JOURNAL OF VIROLOGY

Antiviral Therapy during Primary Simian Immunodeficiency Virus Infection Fails To Prevent Acute Loss of CD4+ T Cells in Gut Mucosa but Enhances Their Rapid Restoration through Central Memory T Cells

(2008) D. Verhoeven et al.   JOURNAL OF VIROLOGY

Characterization of the Follicular Dendritic Cell Reservoir of Human Immunodeficiency Virus Type 1

(2008) B. F. Keele et al.   JOURNAL OF VIROLOGY

Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies

(2008)   LANCET

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection

(2008) Carmela Zincarelli et al.   MOLECULAR THERAPY

Comparative Study of Anti-hepatitis B Virus RNA Interference by Double-stranded Adeno-associated Virus Serotypes 7, 8, and 9

(2008) Chun-Chi Chen et al.   MOLECULAR THERAPY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

(2008) Lin Shen et al.   NATURE MEDICINE

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

(2008) Ryo Takeuchi et al.   NUCLEIC ACIDS RESEARCH

Noncytotoxic Lytic Granule-Mediated CD8+ T Cell Inhibition of HSV-1 Reactivation from Neuronal Latency

(2008) J. E. Knickelbein et al.   SCIENCE

Identification of restriction endonuclease with potential ability to cleave the HSV-2 genome: inherent potential for biosynthetic versus "live" recombinant microbicides

(2008) Misaki Wayengera et al.   Theoretical Biology and Medical Modelling

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH

Molecular Evolution of the Tre Recombinase

(2008) Frank Buchholz   Jove-Journal of Visualized Experiments