Effective Optimization of Antibody Affinity by Phage Display Integrated with High-Throughput DNA Synthesis and Sequencing Technologies

Design and construction of small perturbation mutagenesis libraries for antibody affinity maturation using massive microchip-synthesized oligonucleotides

(2015) Man Xu et al.   JOURNAL OF BIOTECHNOLOGY

The promise and challenge of high-throughput sequencing of the antibody repertoire

(2014) George Georgiou et al.   NATURE BIOTECHNOLOGY

Error removal in microchip-synthesized DNA using immobilized MutS

(2014) Wen Wan et al.   NUCLEIC ACIDS RESEARCH

Deep sequencing of phage display libraries to support antibody discovery

(2013) Ulla Ravn et al.   METHODS

Tailored amino acid diversity for the evolution of antibody affinity

(2012) Andrea González-Muñoz et al.   mAbs

Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing

(2012) Timothy A Whitehead et al.   NATURE BIOTECHNOLOGY

Paratome: an online tool for systematic identification of antigen-binding regions in antibodies based on sequence or structure

(2012) Vered Kunik et al.   NUCLEIC ACIDS RESEARCH

Construction of a rationally designed antibody platform for sequencing-assisted selection

(2012) H. B. Larman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Down-regulation of Overexpressed p185her2/neuProtein of Transformed Cells by the Antibody chA21

(2011) Huihao Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diversity of Phage-Displayed Libraries of Peptides during Panning and Amplification

(2011) Ratmir Derda et al.   MOLECULES

Autoantigen discovery with a synthetic human peptidome

(2011) H Benjamin Larman et al.   NATURE BIOTECHNOLOGY

Beyond natural antibodies: the power of in vitro display technologies

(2011) Andrew R M Bradbury et al.   NATURE BIOTECHNOLOGY

High-resolution mapping of protein sequence-function relationships

(2010) Douglas M Fowler et al.   NATURE METHODS

High-quality gene assembly directly from unpurified mixtures of microarray-synthesized oligonucleotides

(2010) Alex Y. Borovkov et al.   NUCLEIC ACIDS RESEARCH

By-passing in vitro screening—next generation sequencing technologies applied to antibody display and in silico candidate selection

(2010) U. Ravn et al.   NUCLEIC ACIDS RESEARCH

Interactions between anti-ErbB2 antibody A21 and the ErbB2 extracellular domain provide a basis for improving A21 affinity

(2009) Liang Chang et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops

(2008) Emmanuelle Laffly et al.   JOURNAL OF MOLECULAR BIOLOGY