Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression

Life Extension Factor Klotho Prevents Mortality and Enhances Cognition in hAPP Transgenic Mice

(2015) D. B. Dubal et al.   JOURNAL OF NEUROSCIENCE

Identification of Cleavage Sites Leading to the Shed Form of the Anti-Aging Protein Klotho

(2014) Ci-Di Chen et al.   BIOCHEMISTRY

Life Extension Factor Klotho Enhances Cognition

(2014) Dena B. Dubal et al.   Cell Reports

Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women

(2013) Tomoko Matsubara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Decline in muscle strength and running endurance in klotho deficient C57BL/6 mice

(2013) Michael Phelps et al.   BIOGERONTOLOGY

Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood

(2013) Sarah M. Clinton et al.   BRAIN RESEARCH

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

(2013) C.-D. Chen et al.   JOURNAL OF NEUROSCIENCE

Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model

(2013) Xi Kuang et al.   NEUROBIOLOGY OF AGING

Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease

(2013) Richard D. Semba et al.   NEUROSCIENCE LETTERS

Association of Klotho Polymorphisms with Healthy Aging: A Systematic Review and Meta-Analysis

(2013) Danilo Di Bona et al.   REJUVENATION RESEARCH

Nuclear localization of Klotho in brain: an anti-aging protein

(2012) Dwight C. German et al.   NEUROBIOLOGY OF AGING

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

(2012) Tetsu Akimoto et al.   BMC Nephrology

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells

(2011) Ryan E. Forster et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure

(2011) Arifumi Kosakai et al.   BRAIN RESEARCH

Exercise-Induced Cognitive Plasticity, Implications for Mild Cognitive Impairment and Alzheimer’s Disease

(2011) Philip P. Foster et al.   Frontiers in Neurology

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Klotho is a substrate for α-, β- and γ-secretase

(2009) Laura Bloch et al.   FEBS LETTERS

Current understanding of klotho

(2008) Yuhong Wang et al.   AGEING RESEARCH REVIEWS

Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination

(2008) John Papaconstantinou   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice

(2008) M. Shiozaki et al.   NEUROSCIENCE

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA