Recent genetic findings in schizophrenia and their therapeutic relevance

The current and potential impact of genetics and genomics on neuropsychopharmacology

(2015) Paul J. Harrison   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Psychiatric Disorders From Childhood to Adulthood in 22q11.2 Deletion Syndrome: Results From the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome

(2014) Maude Schneider et al.   AMERICAN JOURNAL OF PSYCHIATRY

Effects of Schizophrenia Risk Variation in the NRG1 Gene on NRG1-IV Splicing During Fetal and Early Postnatal Human Neocortical Development

(2014) Clare Paterson et al.   AMERICAN JOURNAL OF PSYCHIATRY

Is There a Flame in the Brain in Psychosis?

(2014) Cameron S. Carter et al.   BIOLOGICAL PSYCHIATRY

Calcium signalling and psychiatric disease: bipolar disorder and schizophrenia

(2014) Michael J. Berridge   CELL AND TISSUE RESEARCH

The synapse in schizophrenia

(2014) Andrew J. Pocklington et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan

(2014) D J Porteous et al.   MOLECULAR PSYCHIATRY

What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit

(2014) C Barkus et al.   MOLECULAR PSYCHIATRY

De novo mutations in schizophrenia implicate synaptic networks

(2014) Menachem Fromer et al.   NATURE

A polygenic burden of rare disruptive mutations in schizophrenia

(2014) Shaun M. Purcell et al.   NATURE

Guidelines for investigating causality of sequence variants in human disease

(2014) D. G. MacArthur et al.   NATURE

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

Large-scale genomics unveils the genetic architecture of psychiatric disorders

(2014) Jacob Gratten et al.   NATURE NEUROSCIENCE

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Schizophrenia Genetics Comes of Age

(2014) Anna C. Need et al.   NEURON

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

Converging Genetic and Functional Brain Imaging Evidence Links Neuronal Excitability to Working Memory, Psychiatric Disease, and Brain Activity

(2014) Angela Heck et al.   NEURON

Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

(2014) Ryan L. Boudreau et al.   NEURON

Risk genes for schizophrenia: Translational opportunities for drug discovery

(2014) Catherine L. Winchester et al.   PHARMACOLOGY & THERAPEUTICS

Unlocking the Treasure Trove: From Genes to Schizophrenia Biology

(2014) S. E. McCarthy et al.   SCHIZOPHRENIA BULLETIN

Genetic modifiers and subtypes in schizophrenia: Investigations of age at onset, severity, sex and family history

(2014) Sarah E. Bergen et al.   SCHIZOPHRENIA RESEARCH

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research

(2014) Conrad Iyegbe et al.   SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY

The emerging roles of TCF4 in disease and development

(2014) Marc P. Forrest et al.   TRENDS IN MOLECULAR MEDICINE

Differential Effects of Common Variants inSCN2Aon General Cognitive Ability, Brain Physiology, and messenger RNA Expression in Schizophrenia Cases and Control Individuals

(2014) Dwight Dickinson et al.   JAMA Psychiatry

Expression ofZNF804Ain Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

(2014) Ran Tao et al.   JAMA Psychiatry

Effects of ZNF804A on auditory P300 response in schizophrenia

(2014) T O'Donoghue et al.   Translational Psychiatry

Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds

(2014) E C del Re et al.   Translational Psychiatry

Beyond GWASs: Illuminating the Dark Road from Association to Function

(2013) Stacey L. Edwards et al.   AMERICAN JOURNAL OF HUMAN GENETICS

How mightZNF804Avariants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis

(2013) Jonathan L. Hess et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Schizophrenia as a Human Leukocyte Antigen-Associated Disease Revisited

(2013) Peter McGuffin et al.   AMERICAN JOURNAL OF PSYCHIATRY

Genome-wide Association Studies: Findings at the Major Histocompatibility Complex Locus in Psychosis

(2013) Aiden Corvin et al.   BIOLOGICAL PSYCHIATRY

Major Histocompatibility Complex I in Brain Development and Schizophrenia

(2013) A. Kimberley McAllister   BIOLOGICAL PSYCHIATRY

The Penetrance of Copy Number Variations for Schizophrenia and Developmental Delay

(2013) George Kirov et al.   BIOLOGICAL PSYCHIATRY

Analysis of copy number variations at 15 schizophrenia-associated loci

(2013) Elliott Rees et al.   BRITISH JOURNAL OF PSYCHIATRY

Spatial and Temporal Mapping of De Novo Mutations in Schizophrenia to a Fetal Prefrontal Cortical Network

(2013) Suleyman Gulsuner et al.   CELL

Distilling Pathophysiology from Complex Disease Genetics

(2013) Aravinda Chakravarti et al.   CELL

Pathogenic rare copy number variants in community-based schizophrenia suggest a potential role for clinical microarrays

(2013) G. Costain et al.   HUMAN MOLECULAR GENETICS

The genomics of schizophrenia: update and implications

(2013) Paola Giusti-Rodríguez et al.   JOURNAL OF CLINICAL INVESTIGATION

Reviewing the ketamine model for schizophrenia

(2013) Joel Frohlich et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Epistatic interaction between COMT and DTNBP1 modulates prefrontal function in mice and in humans

(2013) F Papaleo et al.   MOLECULAR PSYCHIATRY

Questions about DISC1 as a genetic risk factor for schizophrenia

(2013) P F Sullivan   MOLECULAR PSYCHIATRY

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci

(2013) A D Børglum et al.   MOLECULAR PSYCHIATRY

Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders

(2013) E M Kenny et al.   MOLECULAR PSYCHIATRY

The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia

(2013) T A Lett et al.   MOLECULAR PSYCHIATRY

Genetics of rheumatoid arthritis contributes to biology and drug discovery

(2013) Yukinori Okada et al.   NATURE

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

(2013) S Hong Lee et al.   NATURE GENETICS

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

(2013) Stephan Ripke et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Bringing genome-wide association findings into clinical use

(2013) Teri A. Manolio   NATURE REVIEWS GENETICS

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

Progress in the Genetics of Polygenic Brain Disorders: Significant New Challenges for Neurobiology

(2013) Steven A. McCarroll et al.   NEURON

Revitalizing Psychiatric Therapeutics

(2013) Steven E Hyman   NEUROPSYCHOPHARMACOLOGY

Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction

(2013) D. T. Balu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Will Brain Cells Derived From Induced Pluripotent Stem Cells or Directly Converted From Somatic Cells (iNs) Be Useful for Schizophrenia Research?

(2013) C. Filippich et al.   SCHIZOPHRENIA BULLETIN

Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia

(2013) Ming Li et al.   SCHIZOPHRENIA RESEARCH

Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex

(2013) Ilaria Guella et al.   SCHIZOPHRENIA RESEARCH

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

(2013) Ole A. Andreassen et al.   PLoS Genetics

Support for the N -Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families

(2013) Andrew E. Timms et al.   JAMA Psychiatry

Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients

(2013) A Hatzimanolis et al.   Translational Psychiatry

ErbB inhibitors ameliorate behavioral impairments of an animal model for schizophrenia: implication of their dopamine-modulatory actions

(2013) M Mizuno et al.   Translational Psychiatry

Potential Impact of miR-137 and Its Targets in Schizophrenia

(2013) Carrie Wright et al.   Frontiers in Genetics

Evidence That Schizophrenia Risk Variation in theZNF804AGene Exerts Its Effects During Fetal Brain Development

(2012) Matthew J. Hill et al.   AMERICAN JOURNAL OF PSYCHIATRY

Cys2His2 zinc finger protein family: Classification, functions, and major members

(2012) S. V. Razin et al.   BIOCHEMISTRY-MOSCOW

Alternative splicing: Functional diversity among voltage-gated calcium channels and behavioral consequences

(2012) Diane Lipscombe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Confirmation that the AKT1 (rs2494732) Genotype Influences the Risk of Psychosis in Cannabis Users

(2012) Marta Di Forti et al.   BIOLOGICAL PSYCHIATRY

The possible role of the Akt signaling pathway in schizophrenia

(2012) Wenhua Zheng et al.   BRAIN RESEARCH

CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics

(2012) Dheeraj Malhotra et al.   CELL

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Pharmacogenetics of antipsychotics: recent progress and methodological issues

(2012) Jian-Ping Zhang et al.   Expert Opinion on Drug Metabolism & Toxicology

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

Schizophrenia risk gene ZNF804A does not influence macroscopic brain structure: an MRI study in 892 volunteers

(2012) H Cousijn et al.   MOLECULAR PSYCHIATRY

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants

(2012) B J Mowry et al.   MOLECULAR PSYCHIATRY

Use of genome-wide association studies for drug repositioning

(2012) Philippe Sanseau et al.   NATURE BIOTECHNOLOGY

De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia

(2012) Bin Xu et al.   NATURE GENETICS

Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

(2012) S Hong Lee et al.   NATURE GENETICS

Diverse types of genetic variation converge on functional gene networks involved in schizophrenia

(2012) Sarah R Gilman et al.   NATURE NEUROSCIENCE

Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translational gap

(2012) Judith Pratt et al.   NATURE REVIEWS DRUG DISCOVERY

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

ZNF804a Regulates Expression of the Schizophrenia-Associated Genes PRSS16, COMT, PDE4B, and DRD2

(2012) Matthew J. Girgenti et al.   PLoS One

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy

(2012) Amanda J. Law et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

Epigenetic Studies of Schizophrenia: Progress, Predicaments, and Promises for the Future

(2012) Emma Dempster et al.   SCHIZOPHRENIA BULLETIN

Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137

(2012) Albert H. Kim et al.   SCHIZOPHRENIA RESEARCH

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide association analysis of age at onset in schizophrenia in a European-American sample

(2011) Ke-Sheng Wang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Altered Cortical Network Dynamics

(2011) Roberta Rasetti   ARCHIVES OF GENERAL PSYCHIATRY

MeCP2 and Rett syndrome: reversibility and potential avenues for therapy

(2011) Kamal K.E. Gadalla et al.   BIOCHEMICAL JOURNAL

Pharmacogenetics of Response to Antipsychotics in Patients with Schizophrenia

(2011) Maria J. Arranz et al.   CNS DRUGS

From genes to therapeutic targets for psychiatric disorders – what to expect?

(2011) Pierandrea Muglia   CURRENT OPINION IN PHARMACOLOGY

Knockdown of the psychosis susceptibility gene ZNF804A alters expression of genes involved in cell adhesion

(2011) M. J. Hill et al.   HUMAN MOLECULAR GENETICS

Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia

(2011) E S Lips et al.   MOLECULAR PSYCHIATRY

Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets

(2011) E Kwon et al.   MOLECULAR PSYCHIATRY

Allelic differences in nuclear protein binding at a genome-wide significant risk variant for schizophrenia in ZNF804A

(2011) M J Hill et al.   MOLECULAR PSYCHIATRY

Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses

(2011) P M Visscher et al.   MOLECULAR PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Charting a course for genomic medicine from base pairs to bedside

(2011) Eric D. Green et al.   NATURE

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia

(2011) Dheeraj Malhotra et al.   NEURON

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Targeting glutamate synapses in schizophrenia

(2011) Julie R. Field et al.   TRENDS IN MOLECULAR MEDICINE

Structural and functional differences between L-type calcium channels: crucial issues for future selective targeting

(2011) Annalisa Zuccotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

No evidence that rare coding variants in ZNF804A confer risk of schizophrenia

(2010) S. Dwyer et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia

(2010) James T. R. Walters et al.   ARCHIVES OF GENERAL PSYCHIATRY

Biological Validation of Increased Schizophrenia Risk With NRG1, ERBB4, and AKT1 Epistasis via Functional Neuroimaging in Healthy Controls

(2010) Kristin K. Nicodemus et al.   ARCHIVES OF GENERAL PSYCHIATRY

Schizophrenia risk genes: Implications for future drug development and discovery

(2010) Garret O’Connell et al.   BIOCHEMICAL PHARMACOLOGY

Genetic Neuropathology of Schizophrenia: New Approaches to an Old Question and New Uses for Postmortem Human Brains

(2010) Joel E. Kleinman et al.   BIOLOGICAL PSYCHIATRY

Neuregulin 1–erbB4 pathway in schizophrenia: From genes to an interactome

(2010) Anamika Banerjee et al.   BRAIN RESEARCH BULLETIN

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?

(2010) Joshua T. Kantrowitz et al.   BRAIN RESEARCH BULLETIN

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder

(2010) H J Williams et al.   MOLECULAR PSYCHIATRY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New Therapeutic Approaches to Mendelian Disorders

(2010) Harry C. Dietz   NEW ENGLAND JOURNAL OF MEDICINE

MHC class I modulates NMDA receptor function and AMPA receptor trafficking

(2010) L. Fourgeaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strong synaptic transmission impact by copy number variations in schizophrenia

(2010) J. T. Glessner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

(2009) Zachary Freyberg et al.   AMERICAN JOURNAL OF PSYCHIATRY

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

(2009) Paul Lichtenstein et al.   LANCET

Glutamatergic (N-Methyl-D-aspartate Receptor) Hypofrontality in Schizophrenia: Too Little Juice or a Miswired Brain?

(2009) G. J. Marek et al.   MOLECULAR PHARMACOLOGY

The neurobiology of D-amino acid oxidase and its involvement in schizophrenia

(2009) L Verrall et al.   MOLECULAR PSYCHIATRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Neural Mechanisms of a Genome-Wide Supported Psychosis Variant

(2009) C. Esslinger et al.   SCIENCE

Immune involvement in schizophrenia and autism: Etiology, pathology and animal models

(2008) Paul H. Patterson   BEHAVIOURAL BRAIN RESEARCH

Review: The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia

(2008) PJ Harrison et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Conditional forebrain deletion of the L-type calcium channel CaV1.2 disrupts remote spatial memories in mice

(2008) J. A. White et al.   LEARNING & MEMORY

Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk

(2008) K K Nicodemus et al.   MOLECULAR PSYCHIATRY

Psychiatric genetics: The brains of the family

(2008) Alison Abbott   NATURE

Identification of loci associated with schizophrenia by genome-wide association and follow-up

(2008) Michael C O'Donovan et al.   NATURE GENETICS

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database

(2008) Nicole C Allen et al.   NATURE GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Expression of a GRM3 Splice Variant is Increased in the Dorsolateral Prefrontal Cortex of Individuals Carrying a Schizophrenia Risk SNP

(2008) Leah J Sartorius et al.   NEUROPSYCHOPHARMACOLOGY