The application of virus-like particles as vaccines and biological vehicles

Immune checkpoint modulation: Rational design of combination strategies

(2015) Dmitriy Zamarin et al.   PHARMACOLOGY & THERAPEUTICS

Recent progress in vaccination against human papillomavirus-mediated cervical cancer

(2015) Sara J. McKee et al.   REVIEWS IN MEDICAL VIROLOGY

Inhibition of BK virus replication in human kidney cells by BK virus large tumor antigen-specific shRNA delivered by JC virus-like particles

(2014) Mien-Chun Lin et al.   ANTIVIRAL RESEARCH

Overexpression and self-assembly of virus-like particles in Nicotiana benthamiana by a single-vector DNA replicon system

(2014) Ki-Beom Moon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The use of hybrid virus-like particles to enhance the immunogenicity of a broadly protective HPV vaccine

(2014) Mitchell Tyler et al.   BIOTECHNOLOGY AND BIOENGINEERING

The preparation of porcine circovirus type 2 (PCV2) virus-like particles using a recombinant pseudorabies virus and its application to vaccine development

(2014) Jyun-Ni Chi et al.   JOURNAL OF BIOTECHNOLOGY

Vaccine-Derived Polioviruses

(2014) C. C. Burns et al.   JOURNAL OF INFECTIOUS DISEASES

An Outbreak of Type Π Vaccine-Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population

(2014) Hai-Bo Wang et al.   PLoS One

AS04-adjuvanted virus-like particles containing multiple M2 extracellular domains of influenza virus confer improved protection

(2014) Yu-Na Lee et al.   VACCINE

Biomimetic Antigenic Nanoparticles Elicit Controlled Protective Immune Response to Influenza

(2013) Dustin P. Patterson et al.   ACS Nano

Expression and assembly of Norwalk virus-like particles in plants using a viral RNA silencing suppressor gene

(2013) Ana Cláudia Souza et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioengineering virus-like particles as vaccines

(2013) Linda H.L. Lua et al.   BIOTECHNOLOGY AND BIOENGINEERING

Chimeric Derivatives of Hepatitis B Virus Core Particles Carrying Major Epitopes of the Rubella Virus E1 Glycoprotein

(2013) Dace Skrastina et al.   Clinical and Vaccine Immunology

Immunization Against Active Ghrelin Using Virus-Like Particles for Obesity Treatment

(2013) Sara Andrade et al.   CURRENT PHARMACEUTICAL DESIGN

VLPs and particle strategies for cancer vaccines

(2013) Francesca Ungaro et al.   Expert Review of Vaccines

Hepatitis B core–based virus–like particles to present heterologous epitopes

(2013) Kenny Roose et al.   Expert Review of Vaccines

SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier

(2013) Masaaki Kawano et al.   Expert Review of Vaccines

Virus-like particle-based vaccines against hepatitis C virus infection

(2013) Bertrand Bellier et al.   Expert Review of Vaccines

Messenger RNA vaccine based on recombinant MS2 virus-like particles against prostate cancer

(2013) Jinming Li et al.   INTERNATIONAL JOURNAL OF CANCER

Structure-based design and experimental engineering of a plant virus nanoparticle for the presentation of immunogenic epitopes and as a drug carrier

(2013) Caterina Arcangeli et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Display of Neospora caninum surface protein related sequence 2 on Rous sarcoma virus-derived gag protein virus-like particles

(2013) Vipin Kumar Deo et al.   JOURNAL OF BIOTECHNOLOGY

Production and biomedical applications of virus-like particles derived from polyomaviruses

(2013) Erik A. Teunissen et al.   JOURNAL OF CONTROLLED RELEASE

Pattern of activation of human antigen presenting cells by genotype GII.4 norovirus virus-like particles

(2013) Eleonora Ponterio et al.   Journal of Translational Medicine

Chimeric Virus-Like Particle Vaccines Displaying Conserved Enterovirus 71 Epitopes Elicit Protective Neutralizing Antibodies in Mice through Divergent Mechanisms

(2013) X. Ye et al.   JOURNAL OF VIROLOGY

Recent Advances in Mucosal Immunization Using Virus-like Particles

(2013) Gaëlle Vacher et al.   MOLECULAR PHARMACEUTICS

Immunogenic assessment of plant-produced human papillomavirus type 16 L1/L2 chimaeras

(2013) Catherine B. Pineo et al.   PLANT BIOTECHNOLOGY JOURNAL

Chimeric Infectious Bursal Disease Virus-Like Particles as Potent Vaccines for Eradication of Established HPV-16 E7–Dependent Tumors

(2013) Juan Martin Caballero et al.   PLoS One

Generation of a parvovirus B19 vaccine candidate

(2013) Sumana Chandramouli et al.   VACCINE

Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice

(2013) Hao-Yang Li et al.   VACCINE

Virus-like particle vaccine protects against H3N2 canine influenza virus in dog

(2013) Dong-Hun Lee et al.   VACCINE

Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

(2013) Gale E. Smith et al.   VACCINE

Reconstituted plant viral capsids can release genes to mammalian cells

(2013) Odisse Azizgolshani et al.   VIROLOGY

Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants

(2013) Masaaki Kawano et al.   VIROLOGY

Self-assembled HCV core virus-like particles targeted and inhibited tumor cell migration and invasion

(2013) Xiang Li et al.   Nanoscale Research Letters

Production of Japanese encephalitis virus-like particles in insect cells

(2013) Hideki Yamaji et al.   Bioengineered

Tumor Targeting via Integrin Ligands

(2013) Udaya Kiran Marelli et al.   Frontiers in Oncology

Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency

(2012) B. Mohana Subramanian et al.   ANTIVIRAL RESEARCH

Characterization of porcine circovirus type 2 (PCV2) capsid particle assembly and its application to virus-like particle vaccine development

(2012) Pei-Ching Wu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Characterization and immunogenicity of norovirus capsid-derived virus-like particles purified by anion exchange chromatography

(2012) L. Huhti et al.   ARCHIVES OF VIROLOGY

Viral and Non-Viral Approaches for Transient Delivery of mRNA and Proteins

(2012) Juliane W. Schott et al.   CURRENT GENE THERAPY

Virus-like particle nanoreactors: programmed encapsulation of the thermostable CelB glycosidase inside the P22 capsid

(2012) Dustin P. Patterson et al.   Soft Matter

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

(2012) Natasha Kushnir et al.   VACCINE

Bluetongue virus serotype 8 virus-like particles protect sheep against virulent virus infection as a single or multi-serotype cocktail immunogen

(2012) Meredith Stewart et al.   VACCINE

Chimeric hepatitis E virus-like particle as a carrier for oral-delivery

(2012) Pitchanee Jariyapong et al.   VACCINE

Recombinant retrovirus-derived virus-like particle-based vaccines induce hepatitis C virus-specific cellular and neutralizing immune responses in mice

(2012) Christophe Huret et al.   VACCINE

Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41

(2012) C. Pastori et al.   VIROLOGY

Protection against a lethal H5N1 influenza challenge by intranasal immunization with virus-like particles containing 2009 pandemic H1N1 neuraminidase in mice

(2012) Judith D. Easterbrook et al.   VIROLOGY

Immunogenicity of virus-like particles containing modified goose parvovirus VP2 protein

(2012) Zongyan Chen et al.   VIRUS RESEARCH

Chimeric Hepatitis B core antigen virus-like particles displaying the envelope domain III of dengue virus type 2

(2012) Upasana Arora et al.   JOURNAL OF NANOBIOTECHNOLOGY

Encapsulation of gold nanoparticles into self-assembling protein nanoparticles

(2012) Yongkun Yang et al.   JOURNAL OF NANOBIOTECHNOLOGY

A new RNA vaccine platform based on MS2 virus-like particles produced in Saccharomyces cerevisiae

(2011) Shipeng Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Goose parvovirus structural proteins expressed by recombinant baculoviruses self-assemble into virus-like particles with strong immunogenicity in goose

(2011) Huanyu Ju et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human parvovirus B19 virus-like particles: In vitro assembly and stability

(2011) Sandra P. Sánchez-Rodríguez et al.   BIOCHIMIE

Self-Assembled Virus-Like Particles from Rotavirus Structural Protein VP6 for Targeted Drug Delivery

(2011) Qinghuan Zhao et al.   BIOCONJUGATE CHEMISTRY

Surface Functionalization of Virus-Like Particles by Direct Conjugation Using Azide−Alkyne Click Chemistry

(2011) Kedar G. Patel et al.   BIOCONJUGATE CHEMISTRY

Efficient production of chimeric Human papillomavirus 16 L1 protein bearing the M2e influenza epitope in Nicotiana benthamiana plants

(2011) Slavica Matić et al.   BMC BIOTECHNOLOGY

Cell Targeting with Hybrid Qβ Virus-Like Particles Displaying Epidermal Growth Factor

(2011) Jonathan K. Pokorski et al.   CHEMBIOCHEM

Virus-like particles: innate immune stimulators

(2011) Ramadevi Raghunandan   Expert Review of Vaccines

Delivery of chimeric hepatitis B core particles into liver cells

(2011) K.W. Lee et al.   JOURNAL OF APPLIED MICROBIOLOGY

Chimeric Trop2 Virus-like Particles

(2011) Rafael Cubas et al.   JOURNAL OF IMMUNOTHERAPY

The Second-Generation Active A  Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

(2011) C. Wiessner et al.   JOURNAL OF NEUROSCIENCE

Encapsulation of gold nanoparticles by simian virus 40 capsids

(2011) Tingjuan Wang et al.   Nanoscale

Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations

(2011) Huafang Lai et al.   PLANT CELL REPORTS

A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques

(2011) P. Garrone et al.   Science Translational Medicine

Fabrication of influenza virus-like particles using M2 fusion proteins for imaging single viruses and designing vaccines

(2011) Hung-Ju Wei et al.   VACCINE

H9N2 avian influenza virus-like particle vaccine provides protective immunity and a strategy for the differentiation of infected from vaccinated animals

(2011) Dong-Hun Lee et al.   VACCINE

Ebola virus glycoprotein Fc fusion protein confers protection against lethal challenge in vaccinated mice

(2011) Krishnamurthy Konduru et al.   VACCINE

Pandemic H1N1 influenza virus-like particles are immunogenic and provide protective immunity to pigs

(2011) Hyun-Mi Pyo et al.   VACCINE

Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig

(2011) Hye-Young Jeoung et al.   Virology Journal

A novel recombinant pseudorabies virus expressing parvovirus VP2 gene: Immunogenicity and protective efficacy in swine

(2011) Yang Chen et al.   Virology Journal

Vaccination with dengue virus-like particles induces humoral and cellular immune responses in mice

(2011) Shuo Zhang et al.   Virology Journal

Induction of insert-specific immune response in mice by hamster polyomavirus VP1 derived virus-like particles carrying LCMV GP33 CTL epitope

(2011) Egle Mazeike et al.   VIRUS RESEARCH

Construction and Immunological Evaluation of Multivalent Hepatitis B Virus (HBV) Core Virus-Like Particles Carrying HBV and HCV Epitopes

(2010) I. Sominskaya et al.   Clinical and Vaccine Immunology

Virus-like particles in vaccine development

(2010) António Roldão et al.   Expert Review of Vaccines

Efficient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model

(2010) L-S Chen et al.   GENE THERAPY

Generation of Merkel Cell Polyomavirus (MCV)-Like Particles and Their Application to Detection of MCV Antibodies

(2010) A. Touze et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Virus-Like Particle-Based Anti-Nerve Growth Factor Vaccine Reduces Inflammatory Hyperalgesia: Potential Long-Term Therapy for Chronic Pain

(2010) T. A. Rohn et al.   JOURNAL OF IMMUNOLOGY

Memory and Effector CD8 T-cell Responses After Nanoparticle Vaccination of Melanoma Patients

(2010) Daniel E. Speiser et al.   JOURNAL OF IMMUNOTHERAPY

Influenza virus-like particles as an antigen-carrier platform for the ESAT-6 epitope of Mycobacterium tuberculosis

(2010) Florian Krammer et al.   JOURNAL OF VIROLOGICAL METHODS

Assembly and Biological and Immunological Properties of Newcastle Disease Virus-Like Particles

(2010) L. W. McGinnes et al.   JOURNAL OF VIROLOGY

Mammalian Expression of Virus-Like Particles for Advanced Mimicry of Authentic Influenza Virus

(2010) Chia-Ying Wu et al.   PLoS One

Versatile Virus-Like Particle Carrier for Epitope Based Vaccines

(2010) Alain C. Tissot et al.   PLoS One

Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice

(2010) Fu-Shi Quan et al.   PLoS One

Immune responses and expression of the virus-like particle antigen of the porcine encephalomyocarditis virus

(2010) Hye-Young Jeoung et al.   RESEARCH IN VETERINARY SCIENCE

Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV

(2010) Rongxin Zhang et al.   VACCINE

Immunogenicity and efficacy of two types of West Nile virus-like particles different in size and maturation as a second-generation vaccine candidate

(2010) Naohiro Ohtaki et al.   VACCINE

One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions

(2010) Paolo Martelli et al.   VETERINARY MICROBIOLOGY

A VLP-based vaccine targeting domain III of the West Nile virus E protein protects from lethal infection in mice

(2010) Gunther Spohn et al.   Virology Journal

Self-assembly of virus-like particles of porcine circovirus type 2 capsid protein expressed from Escherichia coli

(2010) Shuanghui Yin et al.   Virology Journal

Wanted, dead or alive: New viral vaccines

(2009) Ian J. Amanna et al.   ANTIVIRAL RESEARCH

Expression and characterization of HPV-16 L1 capsid protein in Pichia pastoris

(2009) Silvia Boschi Bazan et al.   ARCHIVES OF VIROLOGY

Assembly of Hybrid Bacteriophage Qβ Virus-like Particles

(2009) Steven D. Brown et al.   BIOCHEMISTRY

Multiepitope peptide-loaded virus-like particles as a vaccine against hepatitis B virus-related hepatocellular carcinoma

(2009) Fei-Xiang Ding et al.   HEPATOLOGY

Cutting Edge: Limited Specialization of Dendritic Cell Subsets for MHC Class II-Associated Presentation of Viral Particles

(2009) Susanne A. Keller et al.   JOURNAL OF IMMUNOLOGY

An enzymatic virus-like particle assay for sensitive detection of virus entry

(2009) Donna M. Tscherne et al.   JOURNAL OF VIROLOGICAL METHODS

Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection

(2009) M. Kalia et al.   JOURNAL OF VIROLOGY

Induction of Long-Term Protective Immune Responses by Influenza H5N1 Virus-Like Particles

(2009) Sang-Moo Kang et al.   PLoS One

Adenovirus Dodecahedron, as a Drug Delivery Vector

(2009) Monika Zochowska et al.   PLoS One

Imaging Viral Behavior in Mammalian Cells with Self-Assembled Capsid-Quantum-Dot Hybrid Particles

(2009) Feng Li et al.   Small

The optimized capsid gene of porcine circovirus type 2 expressed in yeast forms virus-like particles and elicits antibody responses in mice fed with recombinant yeast extracts

(2009) Sergio A. Bucarey et al.   VACCINE

Induction of mucosal and systemic antibody responses against the HIV coreceptor CCR5 upon intramuscular immunization and aerosol delivery of a virus-like particle based vaccine

(2009) Zoe Hunter et al.   VACCINE

Expression and characterization of human group C rotavirus virus-like particles in insect cells

(2009) Kristina B. Clark et al.   VIROLOGY

Vaccination with virus-like particles protects mice from lethal infection of Rift Valley Fever Virus

(2009) Jonas Näslund et al.   VIROLOGY

Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses

(2009) Matthias Habjan et al.   VIROLOGY

Chimeric recombinant rotavirus-like particles as a vehicle for the display of heterologous epitopes

(2009) Andrea Peralta et al.   Virology Journal

Recombinant dengue virus-like particles from Pichia pastoris: efficient production and immunological properties

(2009) Wenquan Liu et al.   VIRUS GENES

Immunodrugs: Therapeutic VLP-Based Vaccines for Chronic Diseases

(2008) Gary T. Jennings et al.   Annual Review of Pharmacology and Toxicology

Chimeric virus-like particles for the delivery of an inserted conserved influenza A-specific CTL epitope

(2008) Wan-Shoo Cheong et al.   ANTIVIRAL RESEARCH

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids and HIV-1 TAT cell penetrating peptide

(2008) Baojun Wei et al.   BIOMEDICINE & PHARMACOTHERAPY

Melanoma vaccine candidates from chimeric hepatitis B core virus-like particles carrying a tumor-associated MAGE-3 epitope

(2008) Andris Kazaks et al.   Biotechnology Journal

Enzyme-Linked Immunosorbent Assays Using Novel Japanese Encephalitis Virus Antigen Improve the Accuracy of Clinical Diagnosis of Flavivirus Infections

(2008) S.-S. Chiou et al.   Clinical and Vaccine Immunology

Active immunization with IL-1 displayed on virus-like particles protects from autoimmune arthritis

(2008) Gunther Spohn et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Immunogenic Display of Diverse Peptides on Virus-like Particles of RNA Phage MS2

(2008) David S. Peabody et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of immunisation against angiotensin II with CYT006-AngQb on ambulatory blood pressure: a double-blind, randomised, placebo-controlled phase IIa study

(2008) Alain C Tissot et al.   LANCET

Imaging the biogenesis of individual HIV-1 virions in live cells

(2008) Nolwenn Jouvenet et al.   NATURE

Cross-Clade Protective Immune Responses to Influenza Viruses with H5N1 HA and NA Elicited by an Influenza Virus-Like Particle

(2008) Rick A. Bright et al.   PLoS One

A Vaccine against Nicotine for Smoking Cessation: A Randomized Controlled Trial

(2008) Jacques Cornuz et al.   PLoS One

Vaccination against GIP for the Treatment of Obesity

(2008) Alma Fulurija et al.   PLoS One

Development of recombinant porcine parvovirus-like particles as an antigen carrier formed by the hybrid VP2 protein carrying immunoreactive epitope of porcine circovirus type 2

(2008) Qunxing Pan et al.   VACCINE

Immunization with virus-like particles of enterovirus 71 elicits potent immune responses and protects mice against lethal challenge

(2008) Yao-Chi Chung et al.   VACCINE

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

(2008) Luca Santi et al.   VACCINE

Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins

(2008) M. Fort et al.   VACCINE

The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex

(2008) Vicky Fachinger et al.   VACCINE

Influenza-pseudotyped Gag virus-like particle vaccines provide broad protection against highly pathogenic avian influenza challenge

(2008) Joel R. Haynes et al.   VACCINE

Noroviral P particle: Structure, function and applications in virus–host interaction

(2008) Ming Tan et al.   VIROLOGY

Rift Valley fever virus structural proteins: expression, characterization and assembly of recombinant proteins

(2008) Li Liu et al.   Virology Journal