Article
Nutrition & Dietetics
Noura B. Younes, Omnia Ahmed Mohamed, Nasser M. Rizk
Summary: This study demonstrates that DHA has the potential to mitigate obesity by reducing the secretion of inflammatory adipokines, oxidative stress, lipolysis, and apoptosis in adipocytes exposed to low O-2 tension-induced hypoxia.
Article
Nutrition & Dietetics
Danielle N. Christifano, Kathleen M. Gustafson, Susan E. Carlson, Nasrin Sultanna, Alexandra Brown, Scott A. Sands, John Colombo, Byron J. Gajewski
Summary: Achieving maternal-newborn docosahexaenoic acid (DHA) equilibrium (EQ) is important for optimizing newborn DHA status. This study aimed to determine the daily DHA intake during pregnancy most likely to result in EQ. The results suggest that an intake of 650mg DHA/day is necessary to increase the potential for EQ at delivery.
Article
Multidisciplinary Sciences
Jiqu Xu, Ben Ni, Congcong Ma, Shuang Rong, Hui Gao, Li Zhang, Xia Xiang, Qingde Huang, Qianchun Deng, Fenghong Huang
Summary: This study found that DHA improves hippocampal insulin sensitivity and cognitive function in aged rats fed a high-fat diet. The therapeutic effects of DHA are achieved by reducing systemic glucose homeostasis dysregulation, hippocampal neuroinflammation, and oxidative stress. In addition, DHA treatment breaks the cycle of hippocampal insulin resistance, Ab burden, and tau hyperphosphorylation, leading to enhanced cognitive capacity.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Fisheries
David Huyben, Teresa Grobler, Chessor Matthew, Marta Bou, Bente Ruyter, Brett Glencross
Summary: The requirement for omega-3 long-chain polyunsaturated fatty acids for Atlantic salmon is relative to the dietary lipid level, with high n-3 diets contributing to increased body weight and weight gain.
Article
Environmental Sciences
Uyun Nurul Aini, Siriporn Lunprom, Alissara Reungsang, Apilak Salakkam
Summary: This study investigates the feasibility of using cassava pulp as a low-cost carbon source for DHA production. Optimized cultivation conditions resulted in higher cell dry mass and DHA productivity using cassava pulp as the carbon source, making it an economical and sustainable method for DHA production.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Chemistry, Medicinal
Shenxu Wang, Jiaojiao Liu, Hongshuai Lv, Xiaoyan Huang, Peng Dong, Qi Wang, Haotong Yang, Si Wang, Xiaohai Li, Jinghua Hu, Dandan Wang, Shengnan Cao, Liangyu Xie, Yikang Shi
Summary: A novel dual drug delivery system based on carboxymethyl dextran (CMD) was developed in this study, which successfully delivered two water-insoluble drugs to tumor sites and exhibited excellent anticancer activities. The system showed high drug loading contents and improved water solubility, and could self-assemble into nanoparticles. The released drugs continuously in plasma and cancer cells, and showed higher distribution in tumor sites compared to traditional drug formulations. The system demonstrated superior antitumor efficacy without causing any weight loss in the mice model.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Marnie Newell, Vera Mazurak, Lynne M. Postovit, Catherine J. Field
Summary: This scoping review examined the clinical evidence of n-3 LCPUFA supplementation in cancer therapy based on 57 clinical trials. The results showed that supplementation with EPA and/or DHA could bring benefits to cancer patients, such as improving immune system, weight maintenance, survival rates, quality of life, and reducing adverse events. However, larger, well-controlled randomized clinical trials are needed to validate these findings before incorporation into treatment.
Article
Agriculture, Dairy & Animal Science
Nicole Frost Nyquist, Lena Burri, Rasmus Bovbjerg Jensen
Summary: Supplementation with krill oil (KO) in horses resulted in an increase in the n-3 index and a decrease in the n-6:n-3 ratio. Five horses were supplemented with KO for 35 days and showed improved red blood cell membrane fatty acid profile. KO was well accepted by the horses and no adverse effects were observed.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Min Wen, Yingcai Zhao, Haohao Shi, Chengcheng Wang, Tiantian Zhang, Yuming Wang, Changhu Xue
Summary: This study compares the efficiency of short-term supplementation of DHA in the form of phospholipids and triglycerides in improving cognitive deficiency in an O-3 Def model during different periods of brain development. Results show that DHA-PL is more effective in improving cognitive deficiency and increasing synapse-associated proteins compared to DHA-TG, particularly for adult O-3 Def offspring.
Article
Multidisciplinary Sciences
Vidyah Manikan, Yusuf Nazir, Aidil Abdul Hamid
Summary: Fructose has a significant positive effect on DHA content in Thraustochytrids, with a less profound impact on DHA biosynthetic capacity. When cultivated in fructose medium, Thraustochytrid species exhibit a slower growth rate but higher biomass and lipid accumulation compared to glucose medium after 48 hours.
Article
Pharmacology & Pharmacy
Kajal Hamidzadeh, Jodi Westcott, Nicholas Wourms, Ashley E. Shay, Anand Panigrahy, Michael J. Martin, Robert Nshimiyimana, Charles N. Serhan
Summary: The production of specialized pro-resolving mediators (SPMs) is crucial in resolving acute inflammation. The authors successfully synthesized a new SPM called 17-epi-NPD1/17-epi-PD1 and confirmed its bioactivities and ability to activate human leukocyte phagocytosis in vivo.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Chen Yang, Zhixian Qiao, Zhenxia Xu, Xu Wang, Qianchun Deng, Wenchao Chen, Fenghong Huang
Summary: In this study, algal oil rich in docosahexaenoic acid was found to alleviate mucosal injury and gut microbiota disorders caused by ceftriaxone sodium (CS). The supplementation of algal oil reduced pro-inflammatory cytokine levels, restored gut microbiota dysbiosis, and regulated metabolic disorders induced by CS, suggesting its potential as a functional food ingredient to protect against antibiotic-induced alterations of gut microbiota and metabolic dysbiosis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Natalie L. Pino-Maureira, Rodrigo R. Gonzalez-Saldia, Alejandro Capdeville, Benjamin Srain
Summary: Using raw glycerol as a carbon source, marine Rhodotorula strains can produce DHA and carotenoids for human and animal nutrition. The study also introduces a new genetically described Rhodotorula strain, NCYC1146, which shows potential for canthaxanthin production when glycerol is used as the main carbon source. This research provides evidence that marine Rhodotorula can utilize an alternative and low-cost carbon source for the sustainable production of essential nutrients.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Eun-Young Ko, Ramesh Kumar Saini, Young-Soo Keum, Byoung-Ki An
Summary: This study compared the nutritional compounds in eggs from laying hens of different ages and found that early-age eggs contained higher levels of vital compounds, while intermediate and late-age eggs had better fat quality. Surprisingly, cholesterol levels did not differ significantly among the age groups.
Article
Nutrition & Dietetics
Aleix Sala-Vila, Nathan Tintle, Jason Westra, William S. Harris
Summary: Dietary omega-3 fatty acids are inversely related to the risk of dementia, particularly in men and individuals aged 60 and above.