Article
Cell Biology
Anne Petzold, Hanna Elin van den Munkhof, Rebecca Figge-Schlensok, Tatiana Korotkova
Summary: By studying freely behaving mice using calcium imaging, optogenetics, and chemogenetics, researchers found that two neuronal populations in the lateral hypothalamus guide hungry animals to make behavioral choices between nutritional and social rewards. One population of neurons increased food consumption by inhibiting hunger signals, while the other population limited feeding and drinking and promoted social interaction despite hunger or thirst. These findings shed light on the neuronal mechanisms of balancing competing needs and provide insights into the flexible fulfillment of essential needs in animals.
Article
Endocrinology & Metabolism
Byong Seo Park, Dasol Kang, Kwang Kon Kim, Bora Jeong, Tae Hwan Lee, Jeong Woo Park, Shioko Kimura, Jung -Yong Yeh, Gu Seob Roh, Chang-Joong Lee, Sungchil Yang, Sunggu Yang, Jae Geun Kim, Byung Ju Lee
Summary: The study reveals that hypothalamic TTF-1 plays a crucial role in leptin signaling and activity, with its selective deletion enhancing the effects of leptin and alleviating obesity caused by leptin resistance. This suggests that TTF-1 may be a potential therapeutic target for the treatment of obesity.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Junewoo Na, Byong Seo Park, Doohyeong Jang, Donggue Kim, Thai Hien Tu, Youngjae Ryu, Chang Man Ha, Marco Koch, Sungchil Yang, Jae Geun Kim, Sunggu Yang
Summary: This study extensively characterizes the AgRP, POMC, and dopaminergic neurons in the hypothalamic arcuate nucleus (Arc). The distinct anatomical and physiological properties of these neurons in response to appetite-regulating hormones are identified. This research highlights the importance of hypothalamic Arc neurons in appetite control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Liliia Butiaeva, Tal Slutzki, Hannah E. Swick, Clement Bourguignon, Sarah C. Robins, Xiaohong Liu, Kai-Florian Storch, Maia Kokoeva
Summary: Studies have shown that LepR pericytes facilitate localized, paracellular blood-brain barrier leaks, enabling MBH LepR neurons to access circulating leptin. Disruption of LepR in pericytes leads to increased food intake, increased fat mass, and loss of leptin-dependent signaling in nearby LepR neurons.
Article
Multidisciplinary Sciences
Ekaterina Martianova, Renata Sadretdinova, Alicia Pageau, Nikola Pausic, Tommy Doucet Gentiletti, Danahe Leblanc, Arturo Marroquin Rivera, Benoit Labonte, Christophe D. Proulx
Summary: The outputs of lateral hypothalamic neurons play a critical role in sensory integration and organizing behavior responses. This study demonstrates the significant coherent activity of three major neuronal outputs projecting to downstream targets during sensory-evoked or self-initiated motor responses in mice.
Review
Neurosciences
Lukas T. Oesch, Antoine R. Adamantidis
Summary: This review focuses on the electrical activity of feeding-promoting cells in the lateral hypothalamus across different states of vigilance, with a specific emphasis on REM sleep and its role in brain plasticity related to energy homeostasis and behavioral optimization.
TRENDS IN NEUROSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Song-Yu Li, Jing-Juan Cao, Kang Tan, Liu Fan, Ya-Qian Wang, Zi-Xuan Shen, Shuai-Shuai Li, Chao Wu, Hui Zhou, Hua-Tai Xu
Summary: Food cues play a pivotal role in triggering physiological responses and have a critical impact on obesity risk. This study revealed the crucial role of corticotropin-releasing hormone (CRH)-expressing neurons in the lateral hypothalamic area in promoting feeding behaviors in mice. The research also identified downstream targets and emphasized the involvement of CRH neuropeptide in orchestrating this regulatory network.
Article
Biochemistry & Molecular Biology
Mahendra Wagle, Mahdi Zarei, Matthew Lovett-Barron, Kristina Tyler Poston, Jin Xu, Vince Ramey, Katherine S. Pollard, David A. Prober, Jay Schulkin, Karl Deisseroth, Su Guo
Summary: This study investigates the role of hypothalamic corticotropin releasing factor neurons in regulating the perception and emotional valence of light. The findings suggest that these neurons play a significant role in light perception and mood disorders, and light therapy may alleviate these disorders by reducing the overall activity of these neurons.
MOLECULAR PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Alice Adriaenssens, Johannes Broichhagen, Anne de Bray, Julia Ast, Annie Hasib, Ben Jones, Alejandra Tomas, Natalie Figueredo Burgos, Orla Woodward, Jo Lewis, Elisabeth O'Flaherty, Kimberley El, Canqi Cui, Norio Harada, Nobuya Inagaki, Jonathan Campbell, Daniel Brierley, David J. Hodson, Ricardo Samms, Fiona Gribble, Frank Reimann
Summary: The signaling pathways of the central glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) in the brain are not fully understood, and its role in GIP-based therapeutics for weight loss is critical. This study found that Gipr neurons in the hypothalamus and dorsal vagal complex (DVC) play a role in the control of energy balance, but they have different connectivity, transcriptomic profiles, and appetite-controlling mechanisms. The study also showed that GIPR agonists have restricted access to the central nervous system, primarily targeting circumventricular organs. These findings highlight the heterogeneity of the central GIPR signaling axis and suggest the need to consider multiple regulatory pathways in studying the effects of GIP pharmacology on feeding behavior.
Review
Cell Biology
Cayo Almeida, Renan Paschoalino Pongilio, Marilia Ines Movio, Guilherme Shigueto Vilar Higa, Rodrigo Ribeiro Resende, Jianxiong Jiang, Erika Reime Kinjo, Alexandre Hiroaki Kihara
Summary: Temporal lobe epilepsy (TLE) is associated with oxidative stress and neuroinflammation, which involve various types of cells. Molecules involved in oxidative stress response and neuroinflammation have been proposed as potential targets for TLE treatment. This review examines the roles of Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase 2 (NOX2) and Myeloid Differentiation Primary Response 88 (MyD88) in astrocytes, microglia, and neurons during epileptogenesis. The use of single-cell RNA sequencing, transgenic technologies, and viral serotypes with specific promoters is also discussed for studying gene expression in different cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dan Chen, Yong Qi, Jia Zhang, Yunlei Yang
Summary: This study reveals the role of astrocytes in regulating adipose sympathetic nerve activity and adipocyte functions, showing that astrocyte stimulation can increase sympathetic activity and promote lipolysis. Additionally, the study found that astrocyte stimulation excites POMC neurons in the arcuate nucleus, which could be a potential target for obesity treatment.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Xiao Lv, Feng Gao, Tuo Peter Li, Peng Xue, Xiao Wang, Mei Wan, Bo Hu, Hao Chen, Amit Jain, Zengwu Shao, Xu Cao
Summary: In this study, it was found that ascending skeleton interoceptive signaling downregulates hypothalamic NPY expression, inducing lipolysis and promoting osteoblastic bone formation. SMILE plays a key role in this process by inhibiting NPY expression. Inhibition of NPY Y1 receptor can rescue bone loss.
Article
Multidisciplinary Sciences
Tomomi Karigo, Ann Kennedy, Bin Yang, Mengyu Liu, Derek Tai, Iman A. Wahle, David J. Anderson
Summary: This study showed that ultrasonic vocalizations can distinguish the intent of mounting behaviors in male laboratory mice, with most male-directed mounting being aggressive. Distinct patterns of neural activity were found in subpopulations of neurons in the medial preoptic area (MPOA) and ventromedial hypothalamus, ventrolateral subdivision (VMHvl) during USV+ and USV- mounting, indicating the encoded behavioral states are represented by different neural populations. Optogenetic stimulation of specific neurons in MPOA and VMHvl could promote or inhibit different types of mounting behaviors, suggesting that distinct hypothalamic neuronal populations mediate the different internal states expressed through similar behaviors.
Article
Medicine, Research & Experimental
Ji Su Sun, Dong Joo Yang, Ann W. Kinyua, Seul Gi Yoon, Je Kyung Seong, Juwon Kim, Seok Jun Moon, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The dysfunction of primary cilia in the ventromedial hypothalamus is linked to impaired energy and skeletal homeostasis, resulting in obesity and increased bone density. Dysfunction of VMH primary cilia leads to decreased sympathetic activation and central leptin resistance, impacting energy expenditure and bone metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Seul Ki Kim, Le Trung Tran, Cherl NamKoong, Hyung Jin Choi, Hye Jin Chun, Yong-ho Lee, MyungHyun Cheon, ChiHye Chung, Junmo Hwang, Hyun-Ho Lim, Dong Min Shin, Yun-Hee Choi, Ki Woo Kim
Summary: The mitochondrial-derived peptide SHLP2 plays a crucial role in energy homeostasis by activating hypothalamic neurons and binding to CXCR7. It protects against obesity and improves insulin sensitivity in mice fed a high-fat diet.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Sophie M. Steculorum, Gustav Collden, Berengere Coupe, Sophie Croizier, Sarah Lockie, Zane B. Andrews, Florian Jarosch, Sven Klussmann, Sebastien G. Bouret
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Review
Physiology
Sebastien Bouret, Barry E. Levin, Susan E. Ozanne
PHYSIOLOGICAL REVIEWS
(2015)
Article
Endocrinology & Metabolism
Gustav Collden, Eglantine Balland, Jyoti Parkash, Emilie Caron, Fanny Langlet, Vincent Prevot, Sebastien G. Bouret
MOLECULAR METABOLISM
(2015)
Article
Physiology
Miranda D. Johnson, Sebastien G. Bouret, Ambrose A. Dunn-Meynell, Christina N. Boyle, Thomas A. Lutz, Barry E. Levin
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Julien Maillard, Soyoung Park, Sophie Croizier, Charlotte Vanacker, Joshua H. Cook, Vincent Prevot, Maithe Tauber, Sebastien G. Bouret
HUMAN MOLECULAR GENETICS
(2016)
Correction
Endocrinology & Metabolism
Jeffrey M. Zigman, Sebastien G. Bouret, Zane B. Andrews
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2016)
Review
Endocrinology & Metabolism
Jeffrey M. Zigman, Sebastien G. Bouret, Zane B. Andrews
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Cell Biology
Sophie Croizier, Vincent Prevot, Sebastien G. Bouret
Review
Toxicology
Donna L. Mendrick, Anna Mae Diehl, Lisa S. Topor, Rodney R. Dietert, Yvonne Will, Michele A. La Merrill, Sebastien Bouret, Vijayalaskshmi Varma, Kenneth L. Hastings, Thaddeus T. Schug, Susan G. Emeigh Hart, Florence G. Burlesona
TOXICOLOGICAL SCIENCES
(2018)
Article
Endocrinology & Metabolism
Kathrin Abegg, Andreas Hermann, Christina N. Boyle, Sebastien G. Bouret, Thomas A. Lutz, Thomas Riediger
FRONTIERS IN ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll
Article
Cell Biology
Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel, Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi
Article
Cell Biology
Eglantine Balland, Julie Dam, Fanny Langlet, Emilie Caron, Sophie Steculorum, Andrea Messina, S. Rasika, Anthony Falluel-Morel, Youssef Anouar, Benedicte Dehouck, Eric Trinquet, Ralf Jockers, Sebastien G. Bouret, Vincent Prevot
Article
Medicine, Research & Experimental
Nicole Bellefontaine, Konstantina Chachlaki, Jyoti Parkash, Charlotte Vanacker, William Colledge, Xavier d'Anglemont de Tassigny, John Garthwaite, Sebastien G. Bouret, Vincent Prevot
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Multidisciplinary Sciences
Brandon D. Kayser, Michael I. Goran, Sebastien G. Bouret