Skeleton interoception regulates bone and fat metabolism through hypothalamic neuroendocrine NPY

Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity

(2021) Chenxu Yan et al.   Nature Communications

The lack of neuropeptide Y‐Y 1 receptor signaling modulates the chemical and mechanical properties of bone matrix

(2020) Daniela M. Sousa et al.   FASEB JOURNAL

Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP/PKA/CREB pathway

(2020) Weixin Xie et al.   Aging-US

An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents

(2020) Sara L. Prescott et al.   CELL

Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones

(2020) Bo Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self

(2020) Wen G. Chen et al.   TRENDS IN NEUROSCIENCES

Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis

(2019) Hao Chen et al.   Nature Communications

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus

(2019) Adilson Guilherme et al.   Nature Reviews Endocrinology

Nerves in Bone: Evolving Concepts in Pain and Anabolism

(2019) Jennifer M Brazill et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The SMILE transcriptional corepressor inhibits cAMP response element–binding protein (CREB)-mediated transactivation of gluconeogenic genes

(2018) Ji-Min Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor

(2018) Zhenlin Yang et al.   NATURE

Neural Sensing of Organ Volume

(2018) Benjamin D. Umans et al.   TRENDS IN NEUROSCIENCES

Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways

(2017) Zhigang Shi et al.   JOURNAL OF CLINICAL INVESTIGATION

Anterograde monosynaptic transneuronal tracers derived from herpes simplex virus 1 strain H129

(2017) Wen-Bo Zeng et al.   Molecular Neurodegeneration

Bone Cell Bioenergetics and Skeletal Energy Homeostasis

(2017) Ryan C. Riddle et al.   PHYSIOLOGICAL REVIEWS

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

Insulin controls food intake and energy balance via NPY neurons

(2017) Kim Loh et al.   Molecular Metabolism

Glucose metabolism in bone

(2017) Courtney M. Karner et al.   BONE

Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts

(2016) Min Hee Park et al.   STEM CELLS

Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow

(2015) M. H. Park et al.   EMBO JOURNAL

Wnt-Lrp5 Signaling Regulates Fatty Acid Metabolism in the Osteoblast

(2015) Julie L. Frey et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

(2015) Y. Zhang et al.   SCIENCE

Regulation of energy homeostasis by the NPY system

(2015) Kim Loh et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

NPY antagonism reduces adiposity and attenuates age-related imbalance of adipose tissue metabolism

(2014) Seongjoon Park et al.   FASEB JOURNAL

Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism

(2014) Wei Zhang et al.   Nutrition & Metabolism

Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN

(2013) Yan-Chuan Shi et al.   Cell Metabolism

Sema3A regulates bone-mass accrual through sensory innervations

(2013) Toru Fukuda et al.   NATURE

Neuropeptide Y Y1 receptor antagonism increases bone mass in mice

(2012) Daniela M. Sousa et al.   BONE

Stress Hormone Epinephrine Enhances Adipogenesis in Murine Embryonic Stem Cells by Up-Regulating the Neuropeptide Y System

(2012) Ruijun Han et al.   PLoS One

The receptive function of hypothalamic and brainstem centres to hormonal and nutrient signals affecting energy balance

(2012) Thomas Riediger   PROCEEDINGS OF THE NUTRITION SOCIETY

Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity

(2011) Pei-Ting Chao et al.   Cell Metabolism

Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)

(2011) Jagannath Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Prostaglandins in bone: bad cop, good cop?

(2010) Katherine A. Blackwell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms

(2009) Cyrille B. Confavreux et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight

(2009) Paul A. Baldock et al.   PLoS One

Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy

(2008) Sandeep Uppal et al.   NATURE GENETICS