Article
Neurosciences
Sissel Norland, Mariann Eilertsen, Ivar Ronnestad, Jon Vidar Helvik, Ana S. Gomes
Summary: The melanocortin system plays a critical role in regulating appetite and food intake in vertebrates. This study focused on mapping the mRNA expression of neuropeptides involved in this system in the brain of Atlantic salmon. The results showed that the lateral tuberal nucleus might serve as the appetite control center in salmon, similar to mammals. Additionally, other brain regions were also found to potentially be involved in regulating food intake.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Muhammad Sufyan Vohra, Khaled Benchoula, Christopher J. Serpell, Wong Eng Hwa
Summary: Obesity is a major health crisis worldwide, regulated by specific neuronal populations in the brain's ARC region. Understanding the cellular and molecular mechanisms in ARC neurons is crucial for managing obesity and maintaining weight loss effectively. Targeting specific ARC circuits may offer a promising strategy for treating obesity with minimal or no side effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Maria Andrikopoulou, Sunil K. Panigrahi, Giselle D. Jaconia, Cynthia Gyamfi-Bannerman, Richard M. Smiley, Gabrielle Page-Wilson
Summary: The study revealed that during early pregnancy, there are specific adaptations in the central regulation of energy balance, including reduced transport of leptin into the brain and decreased melanocortin tone favoring increased appetitive drive.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Junewoo Na, Byong Seo Park, Doohyeong Jang, Donggue Kim, Thai Hien Tu, Youngjae Ryu, Chang Man Ha, Marco Koch, Sungchil Yang, Jae Geun Kim, Sunggu Yang
Summary: This study extensively characterizes the AgRP, POMC, and dopaminergic neurons in the hypothalamic arcuate nucleus (Arc). The distinct anatomical and physiological properties of these neurons in response to appetite-regulating hormones are identified. This research highlights the importance of hypothalamic Arc neurons in appetite control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Ana Basto, Luisa M. P. Valente, Jose L. Soengas, Marta Conde-Sieira
Summary: Understanding the regulation of food intake in fish is crucial for formulating aquafeeds. This study evaluated the short- and mid-term response of European sea bass fed diets with partial and total fishmeal replacement by defatted Tenebrio molitor larvae meal (dTM). The results showed that dTM replacement did not affect food intake regulation in sea bass, but may lead to long-term changes in intermediary metabolism.
Article
Medicine, Research & Experimental
Fabiane Ferreira Martins, Thiago Santos-Reis, Thatiany Souza Marinho, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Summary: The aim of this study was to examine the effects of semaglutide on neuropeptide signaling in the hypothalamic energy metabolism of diet-induced obese mice. The results showed that semaglutide improved leptin sensitivity and anorexigenic signaling, while decreasing orexigenic signaling. Furthermore, semaglutide also affected biometric data and hypothalamic gene expressions. Therefore, semaglutide can activate anorexigenic signaling by restoring leptin, amylin, and POMC pathways in diet-induced obese mice.
Article
Biochemistry & Molecular Biology
Yunseon Jang, Jun Young Heo, Min Joung Lee, Jiebo Zhu, Changjun Seo, Da Hyun Go, Sung Kyung Yoon, Date Yukari, Yuichi Oike, Jong-Woo Sohn, Minho Shong, Gi Ryang Kweon
Summary: The hypothalamic regulation of appetite is crucial for whole-body energy balance. Recent research has shown that angiopoietin-like growth factor (AGF) is expressed in proopiomelanocortin (POMC)-expressing neurons in the hypothalamus and regulated by leptin signaling. These findings provide important insights into the neural mechanisms underlying obesity and anorexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Calvin V. Lieu, Neruja Loganathan, Denise D. Belsham
Summary: The hypothalamus plays a crucial role in maintaining body homeostasis by integrating various signals, including hormones, nutrients, and signaling molecules. Distinct neuronal subpopulations in the hypothalamus regulate functions such as energy balance, reproduction, and circadian rhythms. Changes at the hypothalamic level caused by factors like excessive saturated fatty acid consumption can lead to metabolic diseases, and microRNAs are emerging as potential tools in diagnosis and treatment.
Article
Endocrinology & Metabolism
Taylor Landry, Daniel Shookster, Alec Chaves, Katrina Free, Tony Nguyen, Hu Huang
Summary: Aerobic exercise plays a significant role in modulating neurons involved in appetite regulation, with high intensity exercise potentially suppressing food intake through POMC neuron excitation. Additionally, pre-exercise energy status can differentially affect post-exercise feeding behavior and hypothalamic neuron activity, shedding light on inconsistent results in weight loss intervention studies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Taylor Landry, Daniel Shookster, Alec Chaves, Katrina Free, Tony Nguyen, Hu Huang
Summary: Recent research has shown that aerobic exercise plays an important role in modulating the activity of hypothalamic neurons related to appetite, but most of these studies have been conducted on male rodents. This study aimed to investigate the effects of acute treadmill exercise on hypothalamic neuron populations involved in regulating appetite in female mice. The results demonstrated that moderate to high intensity exercise increased food intake and stimulated the activity of certain appetite-regulating neurons in the hypothalamus of female mice.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bernd Coester, Thomas A. Lutz, Christelle Le Foll
Summary: This study suggests that microglial amylin signaling is not a major player in the control of energy homeostasis in mice, as male mice with depleted CTR in microglia did not show significant differences in weight and metabolism compared to mice without depletion.
Article
Cell Biology
Patrick Sweeney, Michelle N. Bedenbaugh, Jose Maldonado, Pauline Pan, Katelyn Fowler, Savannah Y. Williams, Luis E. Gimenez, Masoud Ghamari-Langroudi, Griffin Downing, Yijun Gui, Colleen K. Hadley, Stephen T. Joy, Anna K. Mapp, Richard B. Simerly, Roger D. Cone
Summary: Research has shown that MC3R plays a crucial role in controlling feeding behavior, primarily through its impact on the AgRP circuitry. While there is sexual dimorphism in the expression of MC3R in different brain regions, there is no sexual dimorphism in AgRP neurons. MC3R is considered a potential therapeutic target for disorders such as anorexia.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Katarzyna Grzelka, Hannah Wilhelms, Stephan Dodt, Marie-Luise Dreisow, Joseph C. Madara, Samuel J. Walker, Chen Wu, Daqing Wang, Bradford B. Lowell, Henning Fenselau
Summary: Restricting caloric intake effectively reduces body weight, but most dieters fail long-term adherence to caloric deficit and eventually regain lost weight. This study reveals the crucial role of synaptic plasticity in hunger-promoting AgRP neurons and identifies a previously unrecognized target to combat regain of lost weight through activity-dependent amplification of synaptic activity originating from paraventricular hypothalamus thyrotropin-releasing (PVHTRH) neurons.
Article
Multidisciplinary Sciences
Amelia M. Douglass, Jon M. Resch, Joseph C. Madara, Hakan Kucukdereli, Ofer Yizhar, Abhinav Grama, Masahito Yamagata, Zongfang Yang, Bradford B. Lowell
Summary: Fasting activates the HPA axis through the inhibition of GABAergic afferents by AgRP neurons in the PVH. This study reveals the neural basis for fasting-induced HPA axis activation and provides insights into the mechanisms underlying stress-induced HPA axis activation.
Review
Cell Biology
Dhanush Haspula, Zhenzhong Cui
Summary: Precise neural regulation is essential for maintaining energy homeostasis. Hypothalamic and brainstem nuclei adjacent to the circumventricular organs play important roles in regulating energy balance. These nuclei receive inputs from other brain regions and circulating signals, allowing them to exert multi-tier control over metabolism. This review focuses on summarizing the mechanisms by which different neuronal subpopulations in the hypothalamus and brainstem regulate key metabolic functions.
Review
Toxicology
Donna L. Mendrick, Anna Mae Diehl, Lisa S. Topor, Rodney R. Dietert, Yvonne Will, Michele A. La Merrill, Sebastien Bouret, Vijayalaskshmi Varma, Kenneth L. Hastings, Thaddeus T. Schug, Susan G. Emeigh Hart, Florence G. Burlesona
TOXICOLOGICAL SCIENCES
(2018)
Article
Endocrinology & Metabolism
Thomas A. Lutz, Bernd Coester, Lynda Whiting, Ambrose A. Dunn-Meynell, Christina N. Boyle, Sebastien G. Bouret, Barry E. Levin, Christelle Le Foll
Article
Biochemical Research Methods
Philippe J. Eugster, Christina N. Boyle, Sylvain Prod'hom, Erika Tarasco, Thierry Buclin, Thomas A. Lutz, Alan G. Harris, Eric Grouzmann
DRUG TESTING AND ANALYSIS
(2018)
Article
Cell Biology
Elena G. Bochukova, Katherine Lawler, Sophie Croizier, Julia M. Keogh, Nisha Patel, Garth Strohbehn, Kitty K. Lo, Jack Humphrey, Anita Hokken-Koelega, Layla Damen, Stephany Donze, Sebastien G. Bouret, Vincent Plagnol, I. Sadaf Farooqi
Review
Endocrinology & Metabolism
Christina Neuner Boyle, Thomas Alexander Lutz, Christelle Le Foll
MOLECULAR METABOLISM
(2018)
Article
Physiology
Seraina S. Senn, Christelle Le Foll, Lynda Whiting, Erika Tarasco, Sonya Duffy, Thomas A. Lutz, Christina Neuner Boyle
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Erika Tarasco, Christina N. Boyle, Giovanni Pellegrini, Myrtha Arnold, Regula Steiner, Thorsten Hornemann, Dimitris Nasias, Dimitris Kardassis, Lynda Whiting, Thomas A. Lutz
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Review
Neurosciences
Christina N. Boyle, Christelle Le Foll
Article
Neurosciences
Bernd Coester, Sydney W. Pence, Soraya Arrigoni, Christina N. Boyle, Christelle Le Foll, Thomas A. Lutz
Article
Immunology
Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel, Martin F. Bachmann
Article
Endocrinology & Metabolism
Simone Carneiro-Nascimento, Jolanta Opacka-Juffry, Adele Costabile, Christina N. Boyle, Adrienne Mueller Herde, Simon M. Ametamey, Hannes Sigrist, Christopher R. Pryce, Michael Patterson
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Psychology, Biological
Miriam Honegger, Thomas A. Lutz, Christina N. Boyle
Summary: The ability of amylin to inhibit food intake is reduced under hypoglycemic conditions, possibly due to the co-sensitivity of AP neurons to amylin and glucose. Amylin can also buffer meal-induced glucose appearance at EU and HYPO levels.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monne Rodriguez, Julia Guenter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Summary: Dysregulated energy metabolism is a major cause of various diseases. OTUB1 plays an important regulatory role in energy metabolism. Deletion of OTUB1 in mice leads to increased energy expenditure and improved glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Christina N. Boyle, Yi Zheng, Thomas A. Lutz
Summary: Amylin, a pancreatic beta-cell hormone, plays important physiological roles in metabolic control, such as regulating satiation, gastric emptying, and glucagon secretion. Amylin analogs have emerged as promising approaches for obesity and diabetes treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)