NRSF: an Angel or a Devil in Neurogenesis and Neurological Diseases

Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF

(2015) Alix Warburton et al.   JOURNAL OF AFFECTIVE DISORDERS

RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function

(2014) Gerald Thiel et al.   CELL AND TISSUE RESEARCH

The Gene Silencing Transcription Factor REST Represses miR-132 Expression in Hippocampal Neurons Destined to Die

(2014) Jee-Yeon Hwang et al.   JOURNAL OF MOLECULAR BIOLOGY

Casein Kinase 1 Suppresses Activation of REST in Insulted Hippocampal Neurons and Halts Ischemia-Induced Neuronal Death

(2014) N. Kaneko et al.   JOURNAL OF NEUROSCIENCE

A protective factor for the ageing brain

(2014) Li-Huei Tsai et al.   NATURE

REST and stress resistance in ageing and Alzheimer’s disease

(2014) Tao Lu et al.   NATURE

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation

(2014) Edmund Nesti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137

(2014) Alix Warburton et al.   SCHIZOPHRENIA BULLETIN

TRF2-Mediated Stabilization of hREST4 Is Critical for the Differentiation and Maintenance of Neural Progenitors

(2014) Patrick Ovando-Roche et al.   STEM CELLS

Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions

(2014) Shira Rockowitz et al.   PLoS Computational Biology

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

(2013) Davide Pozzi et al.   EMBO JOURNAL

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms

(2013) Kuixing Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Polymorphic variation as a driver of differential neuropeptide gene expression

(2013) John P. Quinn et al.   NEUROPEPTIDES

RNA Helicase DDX3 Is a Regulatory Subunit of Casein Kinase 1 in Wnt- -Catenin Signaling

(2013) C.-M. Cruciat et al.   SCIENCE

REST: an oncogene or a tumor suppressor?

(2013) Sara Negrini et al.   TRENDS IN CELL BIOLOGY

Identification of REST-Regulated Genes and Pathways Using a REST-Targeted Antisense Approach

(2013) Yalda Sedaghat et al.   Nucleic Acid Therapeutics

A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease

(2012) Matthew P Wagoner et al.   BMC GENOMICS

REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells

(2012) M. V. Covey et al.   DEVELOPMENT

Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis

(2012) H. Aoki et al.   DEVELOPMENT

Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical results

(2012) Sharon Berendsen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Ubiquitination and deubiquitination of REST and its roles in cancers

(2012) Zhi Huang et al.   FEBS LETTERS

Loss of Brain-enriched miR-124 MicroRNA Enhances Stem-like Traits and Invasiveness of Glioma Cells

(2012) Hongping Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REST Is a Novel Prognostic Factor and Therapeutic Target for Medulloblastoma

(2012) P. Taylor et al.   MOLECULAR CANCER THERAPEUTICS

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

(2012) Alma Rodenas-Ruano et al.   NATURE NEUROSCIENCE

NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP

(2012) Mei Yu et al.   NEUROBIOLOGY OF AGING

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation

(2012) C M Das et al.   ONCOGENE

REST Controls Self-Renewal and Tumorigenic Competence of Human Glioblastoma Cells

(2012) Luciano Conti et al.   PLoS One

Dynamic Status of REST in the Mouse ESC Pluripotency Network

(2012) Sanjay K. Singh et al.   PLoS One

Repressor element-1 silencing transcription factor (REST)-dependent epigenetic remodeling is critical to ischemia-induced neuronal death

(2012) K.-M. Noh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

REST Regulates Oncogenic Properties of Glioblastoma Stem Cells

(2012) Mohamed M. Kamal et al.   STEM CELLS

MicroRNA-9 Modulates Hes1 Ultradian Oscillations by Forming a Double-Negative Feedback Loop

(2012) Boyan Bonev et al.   Cell Reports

REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

(2012) Nikolaj Dietrich et al.   PLoS Genetics

Retinoic acid induces REST degradation and neuronal differentiation by modulating the expression of SCFβ-TRCP in neuroblastoma cells

(2011) Akanksha Singh et al.   CANCER

Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis

(2011) Yuichiro Hatano et al.   CANCER SCIENCE

Conditional Deletion of NRSF in Forebrain Neurons Accelerates Epileptogenesis in the Kindling Model

(2011) Xiao-Ling Hu et al.   CEREBRAL CORTEX

miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion

(2011) Adam Fowler et al.   EUROPEAN JOURNAL OF CANCER

Coassembly of REST and its cofactors at sites of gene repression in embryonic stem cells

(2011) Hong-Bing Yu et al.   GENOME RESEARCH

A signaling loop of REST, TSC2 and  -catenin governs proliferation and function of PC12 neural cells

(2011) R. Tomasoni et al.   JOURNAL OF CELL SCIENCE

The Master Negative Regulator REST/NRSF Controls Adult Neurogenesis by Restraining the Neurogenic Program in Quiescent Stem Cells

(2011) Z. Gao et al.   JOURNAL OF NEUROSCIENCE

REST Interacts with Cbx Proteins and Regulates Polycomb Repressive Complex 1 Occupancy at RE1 Elements

(2011) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry

(2011) XiaoDong Huang et al.   MOLECULAR CELL

Cross-Regulation between an Alternative Splicing Activator and a Transcription Repressor Controls Neurogenesis

(2011) Bushra Raj et al.   MOLECULAR CELL

MicroRNAs in Brain Tumors

(2011) Richard Hummel et al.   MOLECULAR NEUROBIOLOGY

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells

(2011) Zhi Huang et al.   NATURE CELL BIOLOGY

Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice

(2011) L. Cai et al.   NEUROSCIENCE

Repressor Element 1 Silencing Transcription Factor Couples Loss of Pluripotency with Neural Induction and Neural Differentiation

(2011) Chiara Soldati et al.   STEM CELLS

Gene expression profiling in progressively MPTP-lesioned macaques reveals molecular pathways associated with sporadic Parkinson's disease

(2010) Tatsuya Ohnuki et al.   BRAIN RESEARCH

REST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions

(2010) Irfan A. Qureshi et al.   CELL CYCLE

Rest Promotes the Early Differentiation of Mouse ESCs but Is Not Required for Their Maintenance

(2010) Yasuhiro Yamada et al.   Cell Stem Cell

Roles of Hes genes in neural development

(2010) Ryoichiro Kageyama et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

The transcriptional repressor REST/NRSF modulates hedgehog signaling

(2010) Keith P. Gates et al.   DEVELOPMENTAL BIOLOGY

SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution

(2010) Yann Loe-Mie et al.   HUMAN MOLECULAR GENETICS

Expression and functions of the repressor element 1 (RE-1)-silencing transcription factor (REST) in breast cancer

(2010) Hui Lv et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease

(2010) Chiara Soldati et al.   JOURNAL OF NEUROCHEMISTRY

Early Life Stress Enhances Behavioral Vulnerability to Stress through the Activation of REST4-Mediated Gene Transcription in the Medial Prefrontal Cortex of Rodents

(2010) S. Uchida et al.   JOURNAL OF NEUROSCIENCE

A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation

(2010) Pietro Laneve et al.   NUCLEIC ACIDS RESEARCH

Regulation of the NRSF/REST gene by methylation and CREB affects the cellular phenotype of small-cell lung cancer

(2010) A Kreisler et al.   ONCOGENE

Transcriptional Activation of REST by Sp1 in Huntington's Disease Models

(2010) Myriam Ravache et al.   PLoS One

Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

(2010) M.-C. Tsai et al.   SCIENCE

Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

(2010) M. Stapels et al.   Science Signaling

Eradicating the Mediators of Neuronal Death with a Fine-Tooth Comb

(2010) R. S. Zukin   Science Signaling

The Transcription Factor REST Is Lost in Aggressive Breast Cancer

(2010) Matthew P. Wagoner et al.   PLoS Genetics

Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth

(2009) N. Baryawno et al.   CANCER RESEARCH

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells

(2009) H. F. Jorgensen et al.   DEVELOPMENT

Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain

(2009) C. A. Fasano et al.   GENES & DEVELOPMENT

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Is REST required for ESC pluripotency?

(2009) Helle F. Jørgensen et al.   NATURE

Is REST a regulator of pluripotency?

(2009) Noel J. Buckley et al.   NATURE

Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells

(2009) Mei Yu et al.   NEUROSCIENCE RESEARCH

Squelching glioblastoma stem cells by targeting REST for proteasomal degradation

(2009) Peisu Zhang et al.   TRENDS IN NEUROSCIENCES

Profiling RE1/REST-mediated histone modifications in the human genome

(2009) Deyou Zheng et al.   GENOME BIOLOGY

Modulation of CD59 Expression by Restrictive Silencer Factor-Derived Peptides in Cancer Immunotherapy for Neuroblastoma

(2008) R. M. Donev et al.   CANCER RESEARCH

SCG3 Transcript in Peripheral Blood Is a Prognostic Biomarker for REST-Deficient Small Cell Lung Cancer

(2008) A. C. Moss et al.   CLINICAL CANCER RESEARCH

Nontelomeric TRF2-REST Interaction Modulates Neuronal Gene Silencing and Fate of Tumor and Stem Cells

(2008) Peisu Zhang et al.   CURRENT BIOLOGY

Transcription of Genes Encoding Synaptic Vesicle Proteins in Human Neural Stem Cells

(2008) Myriam Ekici et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin Regulates RE1-silencing Transcription Factor/Neuron-restrictive Silencer Factor (REST/NRSF) Nuclear Trafficking Indirectly through a Complex with REST/NRSF-interacting LIM Domain Protein (RILP) and Dynactin p150Glued

(2008) Masahito Shimojo   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the neurosecretory process in pc12 cells is governed by rest

(2008) Rosalba D’Alessandro et al.   JOURNAL OF NEUROCHEMISTRY

REST maintains self-renewal and pluripotency of embryonic stem cells

(2008) Sanjay K. Singh et al.   NATURE

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

(2008) Daniele Guardavaccaro et al.   NATURE

Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data

(2008) Anton Valouev et al.   NATURE METHODS

Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor

(2007) Lichun Jiang et al.   JOURNAL OF NEUROSCIENCE RESEARCH