Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical results

γ-Aminobutyric Acid Inhibits Synergistic Interleukin-6 Release but Not Transcriptional Activation in Astrocytoma Cells

(2017) Joseph D. Roach Jr. et al.   NEUROIMMUNOMODULATION

The Histone Deacetylase Inhibitor Valproic Acid Lessens NK Cell Action against Oncolytic Virus-Infected Glioblastoma Cells by Inhibition of STAT5/T-BET Signaling and Generation of Gamma Interferon

(2012) Christopher A. Alvarez-Breckenridge et al.   JOURNAL OF VIROLOGY

Location, Location, Location: FoxM1 Mediates β-Catenin Nuclear Translocation and Promotes Glioma Tumorigenesis

(2011) Angela Bowman et al.   CANCER CELL

Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments

(2011) S. P. Williams et al.   CANCER RESEARCH

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation

(2011) Xiaohua Zhang et al.   CANCER SCIENCE

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

(2011) L Qiang et al.   CELL DEATH AND DIFFERENTIATION

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic

(2011) Jacob E. Shabason et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The effect of antiepileptic drugs on coagulation and bleeding in the perioperative period of epilepsy surgery: The Cleveland Clinic experience

(2011) Crystal Manohar et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Valproic acid exhibits biphasic effects on apoptotic cell death of activated lymphocytes through differential modulation of multiple signaling pathways

(2011) Qing Chen et al.   Journal of Immunotoxicology

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

(2011) Ching-Hsein Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation

(2011) Krista A. Van Nifterik et al.   JOURNAL OF NEURO-ONCOLOGY

Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas

(2011) Ganeshkumar Rajendran et al.   JOURNAL OF NEURO-ONCOLOGY

Wnt activation is implicated in glioblastoma radioresistance

(2011) Yonghyun Kim et al.   LABORATORY INVESTIGATION

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

(2011) Ying Chen et al.   NATURE NEUROSCIENCE

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

(2011) J. Fu et al.   NEURO-ONCOLOGY

A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03

(2011) Fabio M. Iwamoto et al.   NEURO-ONCOLOGY

Valproic Acid and Warfarin: An Underrecognized Drug Interaction

(2011) Hyue W. Yoon et al.   Neurocritical Care

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma

(2011) M. Weller et al.   NEUROLOGY

Antitumor Effect of Suberoylanilide Hydroxamic Acid and Topotecan in Renal Cancer Cells

(2011) Akinori Sato et al.   ONCOLOGY RESEARCH

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demethylation of Specific Wnt/β-Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure

(2010) Zhongping Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

L-Carnitine for Acute Valproic Acid Overdose: A Systematic Review of Published Cases

(2010) Jerrold Perrott et al.   ANNALS OF PHARMACOTHERAPY

Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation

(2010) Kamil Gotfryd et al.   BMC CANCER

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells

(2010) Sridhar Reddy Chirasani et al.   BRAIN

Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

(2010) S R Green et al.   BRITISH JOURNAL OF CANCER

Global Histone Modification Patterns as Prognostic Markers to Classify Glioma Patients

(2010) B.-l. Liu et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture

(2010) Zhihua An et al.   CANCER LETTERS

Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas

(2010) Benito Campos et al.   CANCER SCIENCE

Phase 1 Study of Valproic Acid in Pediatric Patients with Refractory Solid or CNS Tumors: A Children's Oncology Group Report

(2010) J. M. Su et al.   CLINICAL CANCER RESEARCH

Mechanisms of Synergistic Antileukemic Interactions between Valproic Acid and Cytarabine in Pediatric Acute Myeloid Leukemia

(2010) C. Xie et al.   CLINICAL CANCER RESEARCH

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

Inside HDAC with HDAC inhibitors

(2010) Philippe Bertrand   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Human glioblastoma-initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection

(2010) Jérôme Kroonen et al.   INTERNATIONAL JOURNAL OF CANCER

A Phosphorylation Switch Regulates the Transcriptional Activation of Cell Cycle Regulator p21 by Histone Deacetylase Inhibitors

(2010) Elisabeth Simboeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tale of Protein Lysine Acetylation in the Cytoplasm

(2010) Karin Sadoul et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Physiological Roles of Class I HDAC Complex and Histone Demethylase

(2010) Tomohiro Hayakawa et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line

(2010) Yasumichi Yagi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

(2010) Qinglin Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines

(2010) Bhaswati Sarcar et al.   JOURNAL OF NEURO-ONCOLOGY

Histone Deacetylase Inhibitors Suppress the Expression of Inflammatory and Innate Immune Response Genes in Human Microglia and Astrocytes

(2010) Hyeon-Sook Suh et al.   Journal of Neuroimmune Pharmacology

Sorafenib Plus Valproic Acid for Infant Spinal Glioblastoma

(2010) Christopher Alan Rokes et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Active DNA demethylation: many roads lead to Rome

(2010) Susan C. Wu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells

(2010) Christian Lange et al.   NEUROSCIENCE LETTERS

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone Deacetylase Inhibitors Downregulate Checkpoint Kinase 1 Expression to Induce Cell Death in Non-Small Cell Lung Cancer Cells

(2010) William Brazelle et al.   PLoS One

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

(2010) James E. Bradner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

(2010) J.- H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Repair Targeting and Radiotherapy: A Focus on the Therapeutic Ratio

(2010) John Thoms et al.   SEMINARS IN RADIATION ONCOLOGY

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

(2010) Julia M. Wagner et al.   Clinical Epigenetics

HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A

(2009) Sumihito Togi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

(2009) Charn-Jung Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study

(2009) Stephan Koenig et al.   BLOOD COAGULATION & FIBRINOLYSIS

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

(2009) Annika Lehmann et al.   BMC CANCER

Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol

(2009) Johannes E.A. Wolff et al.   CANCER

HDAC Inhibitor, Valproic Acid, Induces p53-Dependent Radiosensitization of Colon Cancer Cells

(2009) Xufeng Chen et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Potential Therapeutic Effect of Glycogen Synthase Kinase 3  Inhibition against Human Glioblastoma

(2009) K. Miyashita et al.   CLINICAL CANCER RESEARCH

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors

(2009) Tao Liu et al.   EUROPEAN JOURNAL OF CANCER

HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model

(2009) Vishal Kothari et al.   INTERNATIONAL JOURNAL OF CANCER

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

(2009) Vivek Sharma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sensing invasion: Cell surface receptors driving spreading of glioblastoma

(2009) Marcin Teodorczyk et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells

(2009) Fu Xue Chen et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study

(2009) Evanthia Galanis et al.   JOURNAL OF CLINICAL ONCOLOGY

Efficacy of anti-epileptic drugs in patients with gliomas and seizures

(2009) Mèlanie S. M. Breemen et al.   JOURNAL OF NEUROLOGY

BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas

(2009) T. R. Burton et al.   JOURNAL OF NEUROSCIENCE

Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells

(2009) Kyoji Morita et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis

(2009) B Stamatopoulos et al.   LEUKEMIA

HDAC2 regulates chromatin plasticity and enhances DNA vulnerability

(2009) D. C. Marchion et al.   MOLECULAR CANCER THERAPEUTICS

Antiangiogenic therapies for high-grade glioma

(2009) Andrew D. Norden et al.   Nature Reviews Neurology

Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons

(2009) Baoman Li et al.   NEUROPHARMACOLOGY

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

(2009) Tatjana Perisic et al.   NEUROPSYCHOPHARMACOLOGY

Metabolic Enzymes as Oncogenes or Tumor Suppressors

(2009) Craig B. Thompson   NEW ENGLAND JOURNAL OF MEDICINE

DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis

(2009) G Foltz et al.   ONCOGENE

Histone deacetylase inhibitors cooperate with IFN-γ to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8

(2009) S Häcker et al.   ONCOGENE

GSK3β Regulates Differentiation and Growth Arrest in Glioblastoma

(2009) Serdar Korur et al.   PLoS One

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Epigenetic mechanisms in glioblastoma multiforme

(2009) Raman P. Nagarajan et al.   SEMINARS IN CANCER BIOLOGY

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

(2008) Agda KB Lucio-Eterovic et al.   BMC CANCER

Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway

(2008) Gyung-Ah Jung et al.   BMC CELL BIOLOGY

Histone deacetylase inhibitors and genomic instability

(2008) Grégory Eot-Houllier et al.   CANCER LETTERS

Inhibition of transcription factor STAT5b suppresses proliferation, induces G1 cell cycle arrest and reduces tumor cell invasion in human glioblastoma multiforme cells

(2008) Qin-Chuan Liang et al.   CANCER LETTERS

Targeting tumor angiogenesis with histone deacetylase inhibitors

(2008) Leigh Ellis et al.   CANCER LETTERS

Glycogen Synthase Kinase-3 Inhibition Induces Glioma Cell Death through c-MYC, Nuclear Factor- B, and Glucose Regulation

(2008) S. Kotliarova et al.   CANCER RESEARCH

Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors

(2008) Alfonso Duenas-Gonzalez et al.   CANCER TREATMENT REVIEWS

Promoter hypomethylation regulates CD133 expression in human gliomas

(2008) Kouichi Tabu et al.   CELL RESEARCH

Quantitative Assessment of Postoperative Blood Collection in Brain Tumor Surgery Under Valproate Medication

(2008) T. Psaras et al.   ZENTRALBLATT FUR NEUROCHIRURGIE

Postradiation Sensitization of the Histone Deacetylase Inhibitor Valproic Acid

(2008) P. Chinnaiyan et al.   CLINICAL CANCER RESEARCH

A Multiple-Loop, Double-Cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors

(2008) M. S.Q. Kortenhorst et al.   CLINICAL CANCER RESEARCH

Drug interactions between chemotherapeutic regimens and antiepileptics

(2008) K YAP et al.   CLINICAL THERAPEUTICS

Antiepileptic drugsbest practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

(2008) Philip N. Patsalos et al.   EPILEPSIA

Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: Mechanism and substrate specificity

(2008) Wiebke Fischer et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations

(2008) Francesca Rivers et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Selective repression of YKL-40 by NF-κB in glioma cell lines involves recruitment of histone deacetylase-1 and -2

(2008) Krishna P. Bhat et al.   FEBS LETTERS

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma

(2008) Johannes E. A. Wolff et al.   JOURNAL OF NEURO-ONCOLOGY

Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses

(2008) Akihiro Otsuki et al.   MOLECULAR THERAPY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Valproic acid induces polarization, neuronal-like differentiation of a subpopulation of C6 glioma cells and selectively regulates transgene expression

(2008) J.A. Benítez et al.   NEUROSCIENCE

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65

(2008) Christine Buerki et al.   NUCLEIC ACIDS RESEARCH

HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

(2008) Guolin Chai et al.   PLoS One

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells

(2007) F Condorelli et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Mood-Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase-3

(2003) Guang Chen et al.   JOURNAL OF NEUROCHEMISTRY