The Anti-Aging and Tumor Suppressor Protein Klotho Enhances Differentiation of a Human Oligodendrocytic Hybrid Cell Line

Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

(2016) Marie-Thérèse Château et al.   Aging-US

Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer

(2013) Biao Xie et al.   Cancer Cell International

The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS

(2013) C.-D. Chen et al.   JOURNAL OF NEUROSCIENCE

Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner

(2012) Bo Chen et al.   CANCER BIOLOGY & THERAPY

Small-molecule Klotho enhancers as novel treatment of neurodegeneration

(2012) Carmela R Abraham et al.   Future Medicinal Chemistry

Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells

(2012) Guoshun Shu et al.   CELLULAR ONCOLOGY

Promoter methylation and age-related downregulation of Klotho in rhesus monkey

(2011) Gwendalyn D. King et al.   AGE

Identification of novel small molecules that elevate Klotho expression

(2011) Gwendalyn D. King et al.   BIOCHEMICAL JOURNAL

Epigenetic silencing of the tumor suppressor klotho in human breast cancer

(2011) Tami Rubinek et al.   BREAST CANCER RESEARCH AND TREATMENT

Silencing or knocking out the Na+/Ca2+ exchanger-3 (NCX3) impairs oligodendrocyte differentiation

(2011) F Boscia et al.   CELL DEATH AND DIFFERENTIATION

KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer

(2011) L. Abramovitz et al.   CLINICAL CANCER RESEARCH

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer

(2011) Jie Pan et al.   TUMOR BIOLOGY

Cell-type dependent modulation of Notch signaling by the amyloid precursor protein

(2010) Sun Young Oh et al.   JOURNAL OF NEUROCHEMISTRY

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

(2010) Jaehyouk Lee et al.   Molecular Cancer

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Differential expression of apoptotic genes PDIA3 and MAP3K5 distinguishes between low- and high-risk prostate cancer

(2009) Nicole Pressinotti et al.   Molecular Cancer

DISC1 Regulates New Neuron Development in the Adult Brain via Modulation of AKT-mTOR Signaling through KIAA1212

(2009) Ju Young Kim et al.   NEURON

Klotho Expression in Epithelial Ovarian Cancer and its Association with Insulin-Like Growth Factors and Disease Progression

(2008) Lingeng Lu et al.   CANCER INVESTIGATION

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

(2008) N. de la Iglesia et al.   GENES & DEVELOPMENT

NF-κB and epithelial to mesenchymal transition of cancer

(2008) Chengyin Min et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey

(2007) James A. Duce et al.   GLIA