Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists

Treating Depression with SNRIs: Who Will Benefit Most?

(2016) Michael T. Isaac   CNS SPECTRUMS

Crosstalk between 5-HT2cR and PTEN signaling pathway in atypical antipsychotic-induced metabolic syndrome and cognitive dysfunction

(2013) Jun Cai et al.   MEDICAL HYPOTHESES

Aromatic interactions impact ligand binding and function at serotonin 5-HT2CG protein-coupled receptors: receptor homology modelling, ligand docking, and molecular dynamics results validated by experimental studies

(2013) Tania Córdova-Sintjago et al.   MOLECULAR PHYSICS

The dynamics of camphor in the cytochrome P450 CYP101D2

(2013) Shabana Vohra et al.   PROTEIN SCIENCE

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Bendix: intuitive helix geometry analysis and abstraction

(2012) A. C. E. Dahl et al.   BIOINFORMATICS

Single-Stranded DNA within Nanopores: Conformational Dynamics and Implications for Sequencing; a Molecular Dynamics Simulation Study

(2012) Andrew T. Guy et al.   BIOPHYSICAL JOURNAL

The N-terminal region of the human 5-HT2C receptor has as a cleavable signal peptide

(2012) Jan Anker Jahnsen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular determinants for ligand binding at serotonin 5-HT2Aand 5-HT2CGPCRs: Experimental affinity results analyzed by molecular modeling and ligand docking studies

(2012) Tania Córdova-Sintjago et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Homology modeling of the human 5-HT1A, 5-HT2A, D1, and D2 receptors: model refinement with molecular dynamics simulations and docking evaluation

(2012) Beow Keat Yap et al.   JOURNAL OF MOLECULAR MODELING

Striatal Dopamine Release and Genetic Variation of the Serotonin 2C Receptor in Humans

(2012) B. J. Mickey et al.   JOURNAL OF NEUROSCIENCE

The Role of Flexibility and Conformational Selection in the Binding Promiscuity of PDZ Domains

(2012) Márton Münz et al.   PLoS Computational Biology

Drug discovery targeting human 5-HT2C receptors: Residues S3.36 and Y7.43 impact ligand—Binding pocket structure via hydrogen bond formation

(2011) Clinton E. Canal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Predicted Structures and Dynamics for Agonists and Antagonists Bound to Serotonin 5-HT2B and 5-HT2C Receptors

(2011) Soo-Kyung Kim et al.   Journal of Chemical Information and Modeling

Insight into the binding interactions of CYP450 aromatase inhibitors with their target enzyme: a combined molecular docking and molecular dynamics study

(2011) Roberta Galeazzi et al.   JOURNAL OF MOLECULAR MODELING

Anxiolytic effects of 5-HT1A receptors and anxiogenic effects of 5-HT2C receptors in the amygdala of mice

(2011) Qian Li et al.   NEUROPHARMACOLOGY

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination and Reinstatement: Relationship to Feeding Behavior and Impulse Control

(2011) Guy A Higgins et al.   NEUROPSYCHOPHARMACOLOGY

Functional consequences of twoHTR2Cpolymorphisms associated with antipsychotic-induced weight gain

(2011) Matthew J Hill et al.   PHARMACOGENOMICS

Cross-link immunoprecipitation data to detect polymorphisms lying in splicing regulatory motifs

(2011) Francesco Piva et al.   PSYCHIATRIC GENETICS

Therapeutic Potential of 5-HT2CReceptor Ligands

(2011) Nanna H. Jensen et al.   TheScientificWorldJOURNAL

An improvedin silicoselection of phenotype affecting polymorphisms in SLC6A4, HTR1A and HTR2A genes

(2010) Francesco Piva et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Homology Modeling and Docking Evaluation of Aminergic G Protein-Coupled Receptors

(2010) Fiona M. McRobb et al.   Journal of Chemical Information and Modeling

Direct detection of CH/π interactions in proteins

(2010) Michael J. Plevin et al.   Nature Chemistry

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Erratum: Agomelatine, the first melatonergic antidepressant: discovery, characterization and development

(2010) Christian de Bodinat et al.   NATURE REVIEWS DRUG DISCOVERY

Polymorphisms of theHTR2Cgene and antipsychotic-induced weight gain: an update and meta-analysis

(2010) Michelle N Sicard et al.   PHARMACOGENOMICS

Association between HTR2C gene polymorphisms and the metabolic syndrome in patients using antipsychotics: a replication study

(2010) A J Risselada et al.   PHARMACOGENOMICS JOURNAL

Elucidation of the Molecular Basis of Cholecystokinin Peptide Docking to Its Receptor Using Site-Specific Intrinsic Photoaffinity Labeling and Molecular Modeling

(2009) Maoqing Dong et al.   BIOCHEMISTRY

Molecular Dynamics as a Tool in Rational Drug Design: Current Status and Some Major Applications

(2009) Roberta Galeazzi   Current Computer-Aided Drug Design

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

(2009) L. P. Pellissier et al.   MOLECULAR PHARMACOLOGY

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

The structure of human serotonin 2c G-protein-coupled receptor bound to agonists and antagonists

(2008) Jenelle K. Bray et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Fine-tuning serotonin2c receptor function in the brain: Molecular and functional implications

(2008) Kelly A. Berg et al.   NEUROPHARMACOLOGY

Effect of ritanserin, a 5HT2A/2C antagonist, on negative symptoms of schizophrenia: A double-blind randomized placebo-controlled study

(2008) Shahin Akhondzadeh et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Efficient docking of peptides to proteins without prior knowledge of the binding site

(2002) Csaba Hetényi et al.   PROTEIN SCIENCE