Journal
PSYCHIATRIC GENETICS
Volume 22, Issue 2, Pages 88-91Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/YPG.0b013e32834c0bd1
Keywords
association studies; cross-link immunoprecipitation; polymorphisms; splicing
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In a previous study we showed that prediction tools are useful to select single-nucleotide polymorphisms (SNPs) which potentially affect phenotype and therefore guide genotyping in association studies, thus saving time and money. Here we use the recently available RNA cross-link immunoprecipitation data to analyze several genes involved in psychiatric disorders and show which disease-associated SNPs can affect the splicing process by altering splicing factor binding sites. We point out the importance of using cross-link immunoprecipitation data in psychiatry to refine the SNP selection methods, to explain the association found and to plan molecular investigations. Psychiatr Genet 22: 88-91 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
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