Aromatic interactions impact ligand binding and function at serotonin 5-HT2CG protein-coupled receptors: receptor homology modelling, ligand docking, and molecular dynamics results validated by experimental studies

Molecular determinants for ligand binding at serotonin 5-HT2Aand 5-HT2CGPCRs: Experimental affinity results analyzed by molecular modeling and ligand docking studies

(2012) Tania Córdova-Sintjago et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Discovery of 1,2,4-Triazine Derivatives as Adenosine A2A Antagonists using Structure Based Drug Design

(2012) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Drug discovery targeting human 5-HT2C receptors: Residues S3.36 and Y7.43 impact ligand—Binding pocket structure via hydrogen bond formation

(2011) Clinton E. Canal et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenoceptor structure: Ligand docking and mutagenesis studies

(2011) Tania Córdova-Sintjago et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

Progress in Structure Based Drug Design for G Protein-Coupled Receptors

(2011) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the human histamine H1 receptor complex with doxepin

(2011) Tatsuro Shimamura et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Structure and function of an irreversible agonist-β2 adrenoceptor complex

(2011) Daniel M. Rosenbaum et al.   NATURE

Therapeutic Potential of 5-HT2CReceptor Ligands

(2011) Nanna H. Jensen et al.   TheScientificWorldJOURNAL

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

(1R, 3S)-(−)-Trans-PAT: A novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity

(2009) Raymond G. Booth et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New approach to 4-phenyl-β-aminotetralin from 4-(3-halophenyl)tetralen-2-ol phenylacetate

(2009) Adam S. Vincek et al.   TETRAHEDRON LETTERS

Molecular determinants of ligand-directed signaling for the histamine H1 receptor

(2008) R. G. Booth et al.   INFLAMMATION RESEARCH

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

(2008) Michael A. Hanson et al.   STRUCTURE