Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization

Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response

(2015) Jessica C. Pahler et al.   NEOPLASIA

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4

(2010) Patricia A Cronin et al.   BMC CANCER

Why not treat human cancer with interleukin-1 blockade?

(2010) Charles A. Dinarello   CANCER AND METASTASIS REVIEWS

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

NF-κB promotes epithelial–mesenchymal transition, migration and invasion of pancreatic carcinoma cells

(2010) Harald J. Maier et al.   CANCER LETTERS

Lung Metastasis Fails in MMTV-PyMT Oncomice Lacking S100A4 Due to a T-Cell Deficiency in Primary Tumors

(2010) B. Grum-Schwensen et al.   CANCER RESEARCH

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

An Ets2-Driven Transcriptional Program in Tumor-Associated Macrophages Promotes Tumor Metastasis

(2010) T. Zabuawala et al.   CANCER RESEARCH

Matrix Metalloproteinases Contribute Distinct Roles in Neuroendocrine Prostate Carcinogenesis, Metastasis, and Angiogenesis Progression

(2010) L. E. Littlepage et al.   CANCER RESEARCH

Up-regulation of pro-inflammatory genes as adaptation to hypoxia in MCF-7 cells and in human mammary invasive carcinoma microenvironment

(2010) Marco Tafani et al.   CANCER SCIENCE

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation

(2010) T Chihara et al.   CELL DEATH AND DIFFERENTIATION

Interleukin-6 Increases Expression and Secretion of Cathepsin B by Breast Tumor-Associated Monocytes

(2010) Mona Mohamed et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel Bone-Targeted Strategies in Oncology

(2010) S. Vallet et al.   CLINICAL CANCER RESEARCH

Interleukin-6 in bone metastasis and cancer progression

(2010) Tasnim Ara et al.   EUROPEAN JOURNAL OF CANCER

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

(2010) V. Gocheva et al.   GENES & DEVELOPMENT

Lack of an Endogenous Anti-inflammatory Protein in Mice Enhances Colonization of B16F10 Melanoma Cells in the Lungs

(2010) Arjun Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-Conditioned Macrophages Secrete Migration-Stimulating Factor: A New Marker for M2-Polarization, Influencing Tumor Cell Motility

(2010) G. Solinas et al.   JOURNAL OF IMMUNOLOGY

Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells

(2010) Suwen Wei et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression of stromal derived factor-1 (SDF-1) and chemokine receptor (CXCR4) in bone metastasis of renal carcinoma

(2010) Fu-long Zhao et al.   MOLECULAR BIOLOGY REPORTS

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice

(2010) L Sevenich et al.   ONCOGENE

Metastasis-Inducing S100A4 and RANTES Cooperate in Promoting Tumor Progression in Mice

(2010) Birgitte Forst et al.   PLoS One

Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model

(2010) T. Kitamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemokines and chemokine receptors: new insights into cancer-related inflammation

(2010) Gwendal Lazennec et al.   TRENDS IN MOLECULAR MEDICINE

Live Imaging of Innate Immune Cell Sensing of Transformed Cells in Zebrafish Larvae: Parallels between Tumor Initiation and Wound Inflammation

(2010) Yi Feng et al.   PLOS BIOLOGY

The Chemokine Receptor CXCR4 and the Metalloproteinase MT1-MMP Are Mutually Required during Melanoma Metastasis to Lungs

(2009) Rubén A. Bartolomé et al.   AMERICAN JOURNAL OF PATHOLOGY

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy

(2009) A. K. Azab et al.   BLOOD

CD4+ T Cells Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing Protumor Properties of Macrophages

(2009) David G. DeNardo et al.   CANCER CELL

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

Hypoxia-Induced Lysyl Oxidase Is a Critical Mediator of Bone Marrow Cell Recruitment to Form the Premetastatic Niche

(2009) Janine T. Erler et al.   CANCER CELL

Increased Expression of Vascular Endothelial Growth Factor-C and Nuclear CXCR4 in Hepatocellular Carcinoma Is Correlated With Lymph Node Metastasis and Poor Outcome

(2009) Zuolin Xiang et al.   CANCER JOURNAL

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells

(2009) M Kochetkova et al.   CELL DEATH AND DIFFERENTIATION

CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis

(2009) Jian Zhang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer

(2009) Sergei I. Grivennikov et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Chemokine–chemokine receptor axes in melanoma brain metastasis

(2009) Sivan Izraely et al.   IMMUNOLOGY LETTERS

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms

(2009) Braedon McDonald et al.   INTERNATIONAL JOURNAL OF CANCER

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Expression of SDF-1α and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer

(2008) N Yoshitake et al.   BRITISH JOURNAL OF CANCER

Abrogation of TGFβ Signaling in Mammary Carcinomas Recruits Gr-1+CD11b+ Myeloid Cells that Promote Metastasis

(2008) Li Yang et al.   CANCER CELL

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization

(2008) Daniel P. Fitzgerald et al.   CLINICAL & EXPERIMENTAL METASTASIS

CCR9 Homes Metastatic Melanoma Cells to the Small Bowel

(2008) A. Richmond   CLINICAL CANCER RESEARCH

Immune surveillance: a balance between protumor and antitumor immunity

(2008) Suzanne Ostrand-Rosenberg   CURRENT OPINION IN GENETICS & DEVELOPMENT

Nuclear expression of CXCR4 in tumor cells of non–small cell lung cancer is correlated with lymph node metastasis

(2008) Il-Kang Na et al.   HUMAN PATHOLOGY

Selective expression of inhibitory Fcγ receptor by metastatic melanoma impairs tumor susceptibility to IgG-dependent cellular response

(2008) Lydie Cassard et al.   INTERNATIONAL JOURNAL OF CANCER

Twist Is Transcriptionally Induced by Activation of STAT3 and Mediates STAT3 Oncogenic Function

(2008) George Z. Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL12 and CXCR4 in adenocarcinoma of the lung: Association with metastasis and survival

(2008) Patrick L. Wagner et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

(2008) J A Burger et al.   LEUKEMIA

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase

(2008) Sachie Hiratsuka et al.   NATURE CELL BIOLOGY

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

(2008) H. Lin et al.   SCIENCE