Article
Cell Biology
Fernanda O. Lemos, Ian de Ridder, Martin D. Bootman, Geert Bultynck, Jan B. Parys
Summary: PKM2 regulates calcium handling in the cytosol and mitochondria separately, while TAT-D5SD induces apoptosis by disrupting the PKM2:IP3R interaction.
Article
Cell Biology
Jeffrey T. Lock, Ian Parker
Summary: The study found that individual puffs contribute about 40% of the total Ca2+ liberation during global Ca2+ elevations, with the major factor terminating punctate Ca2+ release being a decline in puff frequency. While the amplitudes of large puffs decrease during the flurry, the amplitudes of smaller puffs remain steady, resulting in a modest overall decline in puff amplitudes (around 30%).
Article
Developmental Biology
Rishav Mitra, Shlesha Richhariya, Siddharth Jayakumar, Dimple Notani, Gaiti Hasan
Summary: In fruit fly larvae, the IP3/Ca2+ signals in specific interneurons drive the expression of Set2 gene, essential for pupariation in the absence of dietary protein. This signal-controlled expression of Set2 upregulates key Ca2+-signaling genes through a positive-feedback loop, regulating gene expression for the transition from larval to pupal stages.
Review
Biochemistry & Molecular Biology
Roberto Docampo, Guozhong Huang
Summary: Trypanosoma cruzi and the T. brucei group of parasites are neglected diseases affecting millions of people globally. These microorganisms have complex life cycles involving insect vectors and mammalian hosts, and possess unique signaling pathways and receptor adaptations that differentiate them from their mammalian counterparts.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Iyuki Namekata, Kento Jitsukata, Ayumi Fukuda, Ryosuke Odaka, Shogo Hamaguchi, Hikaru Tanaka
Summary: Intracellular Ca2+-mediated mechanisms are involved in the pacemaker depolarization in both mouse and guinea pig sinus node tissues, but the Na+-Ca2+ exchanger (NCX) current is only involved in mice.
Article
Multidisciplinary Sciences
Wataru Okumura, Takuma Kozono, Hiroyuki Sato, Hitomi Matsui, Tsubasa Takagi, Takashi Tonozuka, Atsushi Nishikawa
Summary: This study demonstrates that Jaw1 increases calcium influx by changing the oscillation pattern and enhancing calcium release activity of ITPR subtypes upon GPCR stimulation. The findings provide insights into the relationship between heterogeneous calcium dynamics and specific ITPR and Jaw1 expression patterns.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Lvying Wu, Jin Chen
Summary: Cell-fate decisions rely on the regulation of multiple signaling molecules and transcription factors. IP3R3, a tetrameric channel, releases Ca2+ in response to extracellular stimuli. Its gating is regulated by ligands and interacting proteins. Understanding the structure and regulation of IP3R3 provides insights into its biological functions and pathogenic mechanisms.
Review
Neurosciences
Kjell Heuser, Rune Enger
Summary: Epilepsy is a common neurological disorder affecting millions worldwide, with current research focusing on neuronal discharges and the role of astrocytes in releasing signaling substances that interact with neurons. The central role of astrocytic Ca2+ signals in promoting ictogenesis and epileptogenesis is increasingly recognized and studied.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Fernanda O. Lemos, Geert Bultynck, Jan B. Parys
Summary: The endoplasmic reticulum (ER) serves as the main Ca2+ store in cells, actively pumping and releasing Ca2+ through SERCA pumps, IP3 receptors, and ryanodine receptors. The function and impact of Ca2+ leakage channels are a major focus of research in this field.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Review
Biology
Derek A. Terrar
Summary: Rhythms of electrical activity in the heart can be influenced by various intracellular organelles, including the sarcoplasmic reticulum, lysosomes, and mitochondria. These organelles can provide timing mechanisms and participate in signaling processes to affect cardiac electrical activity. Calcium ions play multiple roles in carrying electric current, driving sodium-calcium exchange, and activating enzymes. The interaction between intracellular organelles has profound effects on heart rhythms, with sodium-calcium exchange playing a central role.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Physiology
L. A. Blatter, G. Kanaporis, E. Martinez-Hernandez, Y. Oropeza-Almazan, K. Banach
Summary: This passage discusses the process of excitation-contraction coupling in cardiac muscle, comparing the structural and functional attributes of ECC between atrial and ventricular tissue, as well as exploring novel paradigms of atrial ECC and Ca2+ release. Additionally, it delves into the role of the IP3 receptor Ca2+ release channel and its involvement in beat-to-beat ECC, nuclear Ca2+ signaling, and arrhythmogenesis. Finally, it examines electromechanical and Ca2+ alternans and their implications for atrial arrhythmia.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nicolas Rosa, Femke Speelman-Rooms, Jan B. Parys, Geert Bultynck
Summary: Members of the Bcl-2 protein family play important roles in controlling apoptotic cell death. Beyond their well-known functions in the mitochondria, these proteins also modulate intracellular Ca2+ signals originating from the endoplasmic reticulum. Recent studies have revealed new insights into the functions and interactions of Bcl-2 and Bcl-xL, opening up new possibilities for the treatment of Bcl-xL-dependent cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Editorial Material
Cell Biology
Karim Rahhali, Fabio Di Lisa, Nina Kaludercic
Summary: The close contacts between the endoplasmic reticulum and mitochondria are crucial for various cell functions. A recent article in Nature Communications demonstrated that motile IP(3)Rs can quickly transfer Ca2+ at ERMCs, thereby stimulating mitochondrial oxidative metabolism.
Article
Biochemistry & Molecular Biology
Andrew R. Lavik, Karen S. McColl, Fernanda O. Lemos, Martijn Kerkhofs, Fei Zhong, Michael Harr, Daniela Schlatzer, Kozo Hamada, Katsuhiko Mikoshiba, Francesco Crea, Geert Bultynck, Martin D. Bootman, Jan B. Parys, Clark W. Distelhorst
Summary: PKM2 is a highly expressed enzyme in embryonic tissues and cancer cells, playing a role in supporting anabolic processes during tumour formation. This study identifies PKM2 as an inositol 1,4,5-trisphosphate receptor (IP3R)-interacting protein that inhibits intracellular Ca2+ signalling. The interaction occurs at a highly conserved amino acid site and can be disrupted by synthetic peptides. These findings suggest that PKM2 has a novel non-canonical role in regulating intracellular signalling.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Carmen Costas-Ferreira, Lilian R. F. Faro
Summary: Pesticides from different chemical classes exert toxic effects on the nervous system by altering calcium homeostasis, leading to oxidative stress, neuroinflammation, and ultimately neuronal death. Proposed strategies to counteract these effects are also discussed in the review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Michael D. Lovelace, Ben J. Gu, Steven S. Eamegdool, Michael W. Weible, James S. Wiley, David G. Allen, Tailoi Chan-Ling
Article
Physiology
Yue-Kun Ju, Bon Hyang Lee, Sofie Trajanovska, Gouliang Hao, David G. Allen, Ming Lei, Mark B. Cannell
FRONTIERS IN PHYSIOLOGY
(2015)
Article
Physiology
Jie Liu, Li Xin, Victoria L. Benson, David G. Allen, Yue-Kun Ju
FRONTIERS IN PHYSIOLOGY
(2015)
Review
Physiology
David G. Allen, Nicholas P. Whitehead, Stanley C. Froehner
PHYSIOLOGICAL REVIEWS
(2016)
Editorial Material
Physiology
D. G. Allen
Review
Biochemistry & Molecular Biology
Hakan Westerblad, David G. Allen
ANTIOXIDANTS & REDOX SIGNALING
(2011)
Article
Cardiac & Cardiovascular Systems
Marion C. Mohl, Siiri E. Iismaa, Xiao-Hui Xiao, Oliver Friedrich, Soeren Wagner, Vesna Nikolova-Krstevski, Jianxin Wu, Ze-Yan Yu, Michael Feneley, Diane Fatkin, David G. Allen, Robert M. Graham
CARDIOVASCULAR RESEARCH
(2011)
Article
Cell Biology
Wangang Guo, Xiaoqin Shi, Anheng Liu, Guodong Yang, Fang Yu, Qiangsun Zheng, Zikuan Wang, David G. Allen, Zifan Lu
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2011)
Article
Cardiac & Cardiovascular Systems
Yue-Kun Ju, Jie Liu, Bon Hyang Lee, Donna Lai, Elizabeth A. Woodcock, Ming Lei, Mark B. Cannell, David G. Allen
CIRCULATION RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
David G. Allen, Nicholas P. Whitehead
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2011)
Article
Physiology
D. G. Allen, E. Clugston, Y. Petersen, I. V. Roeder, B. Chapman, R. Rudolf
JOURNAL OF APPLIED PHYSIOLOGY
(2011)
Article
Physiology
Bao-Ting Zhang, Nicholas P. Whitehead, Othon L. Gervasio, Trent F. Reardon, Molly Vale, Diane Fatkin, Alexander Dietrich, Ella W. Yeung, David G. Allen
JOURNAL OF APPLIED PHYSIOLOGY
(2012)
Article
Cell Biology
Othon L. Gervasio, William D. Phillips, Louise Cole, David G. Allen
JOURNAL OF CELL SCIENCE
(2011)
Review
Physiology
David G. Allen, Sofie Trajanovska
FRONTIERS IN PHYSIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
