Article
Multidisciplinary Sciences
Rushita A. Bagchi, Emma L. Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A. Tharp, Hanan Qasim, Kathleen M. Gavin, Julie Pires da Silva, Jennifer L. Major, Bradley K. McConnell, Edward Seto, Hening Lin, Timothy A. McKinsey
Summary: This article highlights the importance of lysine myristoylation in regulating protein localization and function, as well as its role in controlling G protein-coupled receptor signaling. Inhibiting HDAC11 may have therapeutic potential for manipulating adipocyte phenotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaomin Song, Xuan Zou, Weipeng Ge, Cuiliu Hou, Zhujie Cao, Hongmei Zhao, Tiantian Zhang, Ling Jin, Yi Fu, Wei Kong, Chen Yan, Jun Cai, Jing Wang
Summary: The study revealed the significant role of IgG and its receptor in hypertension, suggesting a potential mechanism involving the suppression of AT1R internalization in smooth muscle cells. Fc gamma RIIB could be an innovative therapeutic target for hypertension, particularly for patients with autoimmune diseases.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Jihye Seong, Michael Z. Lin
Summary: Optobiochemical control of protein activities using light allows for high spatiotemporal resolution studies of protein functions in living cells. By categorizing, describing, and discussing various photosensory domains and mechanisms, it is possible to better understand and manipulate the effects of these chromophores on proteins.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021
(2021)
Article
Biochemistry & Molecular Biology
Argha Mitra, Arijit Sarkar, Attila Borics
Summary: Research has revealed both structural similarities and receptor-specific differences between G protein-coupled receptors, which could be associated with different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Moriah Gildart Turcotte, Hrishikesh Thakur, Michael S. Kapiloff, Kimberly L. Dodge-Kafka
Summary: Pathological cardiac myocyte hypertrophy, which is a condition characterized by the enlargement of heart cells, is regulated by the pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin. This study reveals that the scaffold protein muscle A-Kinase Anchoring Protein beta (mAKAP beta/AKAP6 beta) organizes perinuclear signalosomes, which are responsible for localized calcium transients and the subsequent activation of calcineurin-dependent NFATc nuclear localization, leading to myocyte hypertrophy upon beta-adrenergic receptor activation. These findings demonstrate the existence of a functionally independent calcium signaling compartment in cardiac myocytes that regulates hypertrophy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Amrita Ahluwalia, Neil Hoa, Debbie Moreira, Daniel Aziz, Karanvir Singh, Khushin N. Patel, Ellis R. Levin
Summary: This study investigates the function of membrane estrogen receptor beta (ER beta) in opposing AngII-induced cardiac cell pathology. The results demonstrate that membrane ER beta plays a crucial role in mitigating cardiac cell pathology and provides insights into the mechanisms of cardiac hypertrophy and fibrosis.
Article
Biotechnology & Applied Microbiology
Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Summary: This study utilized computational models and software tools to analyze the mechanisms regulating the switch between permanent and transient cartilage, identifying potential therapeutic opportunities. Combinatorial treatments were tested and validated experimentally, showing both positive and negative effects on cartilage formation and growth, providing insights for interventions in normal cartilage development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jin-Fan Zhang, Sohum Mehta, Jin Zhang
Summary: The review discusses how genetically encoded fluorescent biosensors are used to visualize dynamic signaling events in their native cellular context, revealing the different strategies employed by cells to ensure functional specificity by organizing signaling activities into discrete compartments or signaling microdomains.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Biochemistry & Molecular Biology
Jaime Balderas-Villalobos, J. M. Lourdes Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Janee Hayles, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit
Summary: Frequent premature ventricular contractions (PVCs) in a large animal model of PVC-induced cardiomyopathy (PVC-CM) resulted in eccentric cardiac hypertrophy and reduced ejection fraction. The molecular mechanisms and markers of this hypertrophic remodeling were explored. Pathological hypertrophy markers were unaltered, while prohypertrophic and antiapoptotic pathways were activated in the PVC-CM group.
Article
Health Care Sciences & Services
Richard J. Roberts, Logan Hallee, Chi Keung Lam
Summary: Hsp90 is a key molecular chaperone that interacts with numerous disease pathways in cells, making it a potential therapeutic target. While small-molecule inhibition of Hsp90 activity may have cardiac toxicity, targeting Hsp90 through modulation of post-translational modifications (PTMs) could be a more attractive therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Lu Gao, Sen Guo, Rui Long, Lili Xiao, Rui Yao, Xiaolin Zheng, Yanzhou Zhang, Xiaofang Wang
Summary: LAPTM5 is involved in pathological cardiac hypertrophy by binding to Rac1 and inhibiting the MEK-ERK1/2 signaling pathway, ultimately regulating the development of hypertrophy. Targeting LAPTM5 may hold great therapeutic potential in treating pathological cardiac hypertrophy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Cesare Cuspidi, Marijana Tadic, Carla Sala, Stefano Carugo, Giuseppe Mancia, Guido Grassi
Summary: This systematic meta-analysis found an unfavorable association between the reverse dipping pattern and subclinical cardiac alterations, with reverse dippers showing higher left ventricular mass index and relative wall thickness compared to dippers and nondippers. The study suggests that detecting this blood pressure phenotype may help identify individuals at increased risk for subclinical organ damage.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Cesare Cuspidi, Marijana Tadic, Carla Sala, Fosca Quarti-Trevano, Elisa Gherbesi, Giuseppe Mancia, Guido Grassi
Summary: This systematic meta-analysis of echocardiographic studies on primary aldosteronism patients after adrenalectomy found that the procedure can lead to a reduction in left ventricular hypertrophy and an improvement in left ventricular structure and geometry.
JOURNAL OF HYPERTENSION
(2021)
Review
Sport Sciences
Myles N. Moore, Rachel E. Climie, Petr Otahal, James E. Sharman, Martin G. Schultz
Summary: Exercise systolic blood pressure is associated with changes in cardiac structure, and individuals with a hypertensive response to exercise show evidence of adverse cardiac remodeling. These findings were consistent across different study populations, highlighting the cardiovascular risk associated with a hypertensive response to exercise.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2021)
Review
Biochemistry & Molecular Biology
Tatsuo Kawai, Katherine J. Elliott, Rosario Scalia, Satoru Eguchi
Summary: ADAMs play a key role in cell signaling by shedding cytokines and growth factors, leading to cell proliferation and inflammation. Among them, ADAM17 is the most extensively studied member and may have significant implications in cardiovascular diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiahui Jiang, Cong Lan, Liangpeng Li, Dezhong Yang, Xuewei Xia, Qiao Liao, Wenbin Fu, Xiongwen Chen, Songzhu An, Wei Eric Wang, Chunyu Zeng
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Correction
Medicine, Research & Experimental
Dezhong Yang, Wenbin Fu, Liangpeng Li, Xuewei Xia, Qiao Liao, Rongchuan Yue, Hongmei Chen, Xiongwen Chen, Songzhu An, Chunyu Zeng, Wei Eric Wang
Article
Cardiac & Cardiovascular Systems
Ying Zhang, Wei Eric Wang, Xiaoying Zhang, Ying Li, Biyi Chen, Chong Liu, Xiaojie Ai, Xiaoxiao Zhang, Ying Tian, Chen Zhang, Mingxin Tang, Christopher Szeto, Xiang Hua, Mingxin Xie, Chunyu Zeng, Yingjie Wu, Lin Zhou, Weizhong Zhu, Daohai Yu, Steven R. Houser, Xiongwen Chen
CIRCULATION RESEARCH
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Xiongwen Chen, Xiaoying Zhang, Scott Gross, Steven R. Houser, Jonathan Soboloff
CIRCULATION RESEARCH
(2019)
Article
Nutrition & Dietetics
Jining Yang, Xiaoying Zhang, Long Yi, Ling Yang, Wei Eric Wang, Chunyu Zeng, Mantian Mi, Xiongwen Chen
NUTRITION & METABOLISM
(2019)
Article
Cardiac & Cardiovascular Systems
Polina Gross, Jaslyn Johnson, Carlos M. Romero, Deborah M. Eaton, Claire Poulet, Jose Sanchez-Alonso, Carla Lucarelli, Jean Ross, Andrew A. Gibb, Joanne F. Garbincius, Jonathan Lambert, Erdem Varol, Yijun Yang, Markus Wallner, Eric A. Feldsott, Hajime Kubo, Remus M. Berretta, Daohai Yu, Victor Rizzo, John Elrod, Abdelkarim Sabri, Julia Gorelik, Xiongwen Chen, Steven R. Houser
Summary: The joining region in JPH2 interacts with LTCC-alpha 1C subunit, causing LTCCs to distribute to dyads and colocalize with RyRs, facilitating dyad assembly and maintaining normal CICR in cardiomyocytes. Disruption of this interaction leads to T-tubule remodeling, impaired excitation-contraction coupling, and altered myocyte bioenergetics.
CIRCULATION RESEARCH
(2021)
Review
Physiology
Chong Liu, Ping Ke, Jingjing Zhang, Xiaoying Zhang, Xiongwen Chen
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Lixiao Zhen, Qian Zhao, Jinhui Lu, Shengqiong Deng, Zhen Xu, Lin Zhang, Yuzhen Zhang, Huimin Fan, Xiongwen Chen, Zhongmin Liu, Yuying Gu, Zuoren Yu
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Pharmacology & Pharmacy
Jing Wang, Tianshu Liu, Xiongwen Chen, Qiaofeng Jin, Yihan Chen, Li Zhang, Zhengyang Han, Dandan Chen, Yuman Li, Qing Lv, Mingxing Xie
Summary: Th17 cells play a significant role in the pathogenesis of myocarditis, and Bazedoxifene can affect STAT3 signaling to effectively inhibit the progression of cardiac inflammation. Therefore, Bazedoxifene may be a promising therapeutic strategy for the treatment of experimental autoimmune myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Ya Liu, Xiongwen Chen, Hai-Gang Zhang
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yijia Li, Xiongwen Chen, Yue Qi, Yichen Qu, Akshay Kumar, Songbo Dong, Yan Yang, Qiong Zhao
Summary: This study evaluated the impact of gender on Sievers types, valvulopathy, aortopathy, and outcomes of aortic valve replacement (AVR) in Chinese patients with bicuspid aortic valve (BAV). The results showed that male patients had more severe valvulopathy and aortopathy, as well as a higher risk of left ventricular dysfunction after AVR. Importantly, male patients developed these conditions at a younger age.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2022)
Article
Cardiac & Cardiovascular Systems
Yijia Li, Jaslyn P. Johnson, Yijun Yang, Daohai Yu, Hajime Kubo, Remus M. Berretta, Tao Wang, Xiaoying Zhang, Michael Foster, Jun Yu, Douglas G. Tilley, Steven R. Houser, Xiongwen Chen
Summary: Maternal hypothyroidism can negatively impact the cardiac disease responses of offspring by reducing early postnatal cardiomyocyte proliferation and resulting in a smaller number of larger cardiac myocytes. These changes are associated with more severe cardiac disease responses following injury.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Zhang, Yijia Li, Xiaoying Zhang, Valentino Piacentino, David M. Harris, Remus Berretta, Kenneth B. Margulies, Steven R. Houser, Xiongwen Chen
Article
Cell Biology
Tongtong Cao, Daniela Liccardo, Ryan LaCanna, Xiaoying Zhang, Rong Luz, Brian N. Finck, Tani Leigh, Xiongwen Chen, Konstantinos Drosatos, Ying Tian
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2019)
Meeting Abstract
Biotechnology & Applied Microbiology
Yinxia Xu, Junping Zhang, Xiaoying Zhang, Ping Guo, Helen Chew, Matthew Chrzanowski, Jenni Firrman, Nianli Sang, Xiongwen Chen, Yong Diao, Weidong Xiao
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)