Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A

New aspects in cardiac L-type Ca2+ channel regulation

(2020) Tamara Pallien et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

PKA functions in metabolism and resistance to obesity: lessons from mouse and human studies

(2020) Edra London et al.   JOURNAL OF ENDOCRINOLOGY

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

(2020) Cristina Olivieri et al.   eLife

Protein kinase A inhibitor proteins (PKIs) divert GPCR‐Gαs‐cAMP signaling toward EPAC and ERK activation and are involved in tumor growth

(2020) James J. Hoy et al.   FASEB JOURNAL

Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart

(2019) Ying Zhang et al.   CIRCULATION RESEARCH

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A

(2019) Jascha T. Manschwetus et al.   MOLECULES

Cardiac function modulation depends on the A‐kinase anchoring protein complex

(2019) Yan‐Rong Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial cAMP-PKA signaling: What do we really know?

(2018) Yasmine Ould Amer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Norepinephrine inhibits the cytotoxicity of NK92‑MI cells via the β2‑adrenoceptor/cAMP/PKA/p‑CREB signaling pathway

(2018) Zan Sun et al.   Molecular Medicine Reports

Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders

(2018) Angela R. Wild et al.   PHARMACOLOGY & THERAPEUTICS

Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane

(2018) Alex Burdyga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding mechanism and dynamic conformational change of C subunit of PKA with different pathways

(2017) Wen-Ting Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local protein kinase A action proceeds through intact holoenzymes

(2017) F. Donelson Smith et al.   SCIENCE

Cannabinoid receptor-2 stimulation suppresses neuroinflammation by regulating microglial M1/M2 polarization through the cAMP/PKA pathway in an experimental GMH rat model

(2016) Yihao Tao et al.   BRAIN BEHAVIOR AND IMMUNITY

In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability

(2016) Fumio Yamauchi et al.   CANCER RESEARCH

Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition

(2016) Liang Zhang et al.   HUMAN REPRODUCTION

The Natural cAMP Elevating Compound Forskolin in Cancer Therapy: Is It Time?

(2016) Luigi Sapio et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60

(2016) Shiori Akabane et al.   MOLECULAR CELL

Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling

(2016) Verena A. Bachmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling

(2015) Alessandro Dema et al.   CELLULAR SIGNALLING

A historical overview of protein kinases and their targeted small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

PKA Inhibitor H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulfonamide) Attenuates Synaptic Dysfunction and Neuronal Cell Death following Ischemic Injury

(2015) Juhyun Song et al.   NEURAL PLASTICITY

Protein kinase A type II-α regulatory subunit regulates the response of prostate cancer cells to taxane treatment

(2014) Evan R Zynda et al.   CELL CYCLE

Compartmentalization Role of A-Kinase Anchoring Proteins (AKAPs) in Mediating Protein Kinase A (PKA) Signaling and Cardiomyocyte Hypertrophy

(2014) Abeer Rababa'h et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High cAMP attenuation of insulin-stimulated meiotic G2-M1 transition in zebrafish oocytes: Interaction between the cAMP-dependent protein kinase (PKA) and the MAPK3/1 pathways

(2014) Sudipta Maitra et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Manipulation of Endogenous Kinase Activity in Living Cells Using Photoswitchable Inhibitory Peptides

(2014) Jason J. Yi et al.   ACS Synthetic Biology

Adiponectin inhibits oxidative/nitrative stress during myocardial ischemia and reperfusion via PKA signaling

(2013) Yanqing Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition

(2013) Hiroko Inoue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reduction of inorganic phosphate-induced human smooth muscle cells calcification by inhibition of protein kinase A and p38 mitogen-activated protein kinase

(2013) Jeong-Hun Kang et al.   HEART AND VESSELS

Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation

(2013) J. Toneatto et al.   JOURNAL OF CELL SCIENCE

Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation

(2013) F Donelson Smith et al.   eLife

Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway

(2012) I-Chen Peng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardiotoxic and Cardioprotective Features of Chronic β-Adrenergic Signaling

(2012) Xiaoying Zhang et al.   CIRCULATION RESEARCH

Participation of cAMP-dependent protein kinase and MAP kinase pathways during Anabas testudineus oocyte maturation

(2012) P.P. Khan et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Assembly of allosteric macromolecular switches: lessons from PKA

(2012) Susan S. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution of the eukaryotic protein kinases as dynamic molecular switches

(2012) S. S. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The AGC Kinase Inhibitor H89 Attenuates Airway Inflammation in Mouse Models of Asthma

(2012) Laurent L. Reber et al.   PLoS One

The cAMP-Dependent Protein Kinase Pathway as Therapeutic Target – Possibilities and Pitfalls

(2011) Rune Kleppe et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89

(2011) Cuauhtemoc Gomez-Concha et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation

(2011) Archana Gangopahyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An inhibitor of cAMP-dependent protein kinase induces behavioural and neurological antidepressant-like effects in rats

(2011) Nico Liebenberg et al.   NEUROSCIENCE LETTERS

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and β-adrenergic reserve of hearts with increased Cav1.2 activity

(2010) Mingxin Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Conformationally constrained analogs of protein kinase inhibitor(6-22)amide: Effect of turn structures in the center of the peptide on inhibition of cAMP-dependent protein kinase

(2010) David B. Glass et al.   PROTEIN SCIENCE

Mouse models of altered protein kinase A signaling

(2009) Lawrence S Kirschner et al.   ENDOCRINE-RELATED CANCER

Prostaglandin E2-Induced Masculinization of Brain and Behavior Requires Protein Kinase A, AMPA/Kainate, and Metabotropic Glutamate Receptor Signaling

(2009) C. L. Wright et al.   JOURNAL OF NEUROSCIENCE

N6-Substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a Protein Kinase A-Independent Mechanism

(2009) H. Liu et al.   MOLECULAR PHARMACOLOGY

Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA

(2008) Bastian Zimmermann et al.   BIOCHEMICAL JOURNAL

ACTH Inhibits bTREK-1 K+Channels through Multiple cAMP-dependent Signaling Pathways

(2008) Haiyan Liu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling