Article
Food Science & Technology
Esther Santamaria, Alicia Maestro, Carmen Gonzalez
Summary: Nanoemulsions were prepared using a low-energy emulsification method and encapsulated into alginate beads. The beads were coated with chitosan and pullulan to improve the release kinetics of carvacrol. The chitosan-coated beads showed sustained release patterns and avoided the initial burst effect.
Article
Chemistry, Applied
Ling Tang, Yi-Hong Chen, Qiong Wang, Xiao-Hui Wang, Qing-Xi Wu, Zhi-Feng Ding
Summary: The study focused on overcoming the challenges bioactive proteins face in the harsh gastric environment, utilizing microencapsulation as a strategy to protect them. Bovine serum albumin and ovalbumin were used as model proteins, with a polylysine-alginate complex fabricated for microencapsulation. Results showed that the protein-loaded microcapsules exhibited excellent tolerability to the acidic gastric environment, with slow release in simulated gastric fluids and sustained release in intestinal fluids. The developed microcapsules could potentially be used as a vehicle for bioactive proteins in functional foods, health care products, and medical formulations.
Article
Chemistry, Applied
Alexandra N. Kovacs, Norbert Varga, Adam Juhasz, Edit Csapo
Summary: A protein-polysaccharide-based potential nanocarrier system has been developed using a simple, one-step preparation method, avoiding long-term heating and the use of hard to remove crosslinking agents, surfactants, and toxic organic solvents. The pH-dependent quantitative relationship between BSA and HyA has been detailed in this study, with the particle charge titrations studies supporting a core-shell type structure of the colloidal complex nanoconjugates. The study also included drug encapsulation capacity and dissolution profiles for IBU and 2-PA as model drugs.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Miao Hu, Xiaoqian Du, Guannan Liu, Yuyang Huang, Baokun Qi, Yang Li
Summary: This study successfully fabricated hydrogel beads with low porosity and high antioxidation activities by using covalent and noncovalent conjugation of soy protein isolate modified with EGCG complexes, followed by complexation with SA. Experimental analysis showed that these hydrogel beads have smoother surfaces, thicker shells, lower porosity, and significantly higher antioxidant activities.
Article
Multidisciplinary Sciences
Kanjana Singh, Benu Adhikari, Julia Low, Margaret Anne Brennan, Lisa Newman, Charles Stephen Brennan, Niramon Utama-ang
Summary: This study investigates the ability of shell formulations comprised of alginate and glucono delta lactone (GDL) to encapsulate a mixture of green tea and turmeric extracts. The results show that increasing the concentration of alginate and GDL improves the retention of catechin and curcuminoid contents, encapsulation efficiency, and consumer acceptance. Thermal treatment also increases the retention of catechin and curcuminoid contents and reduces pungent flavor and bitterness.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Rui-xia Li, Jiang-lan Yuan, Chang-sheng Ding, Xu Kang
Summary: This study successfully fabricated BSA cold-set emulsion gels using MTGase and GDL, and evaluated their embedding potential for quercetin and VE. The results showed that hardness and springiness decreased with increasing GDL, while water-holding capacity was positively correlated to GDL addition. The study shed light on the rational design of food protein gels for protecting, stabilizing, and delivering small hydrophobic bioactive molecules.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Lan Wang, Jin Mao, Qi Zhou, Qianchun Deng, Lei Zheng, Jie Shi
Summary: Curcumin-loaded bovine serum albumin/carboxymethylpachymaran nanoparticles (BMCNPs) were fabricated to enhance the solubility and stability of curcumin. The optimized BMCNPs had excellent encapsulation efficiency and showed sustained release of curcumin in the small intestine stage. In vitro cytotoxicity tests also confirmed the biocompatibility of BMCNPs.
Article
Biochemistry & Molecular Biology
Niuosha Sanaeifar, Karsten Maeder, Dariush Hinderberger
Summary: We report extended ethanol-induced gelation procedures of bovine serum albumin (BSA) at 37 degrees C and investigate the release behavior of a spin-labeled naproxen derivative (SL-NPX) from these hydrogels. The alteration of initial drug loading percentage, hydrogel incubation time, BSA and alcohol concentrations affect the release rate of SL-NPX from BSA hydrogels. BSA hydrogels offer a remarkable fine-tuning capability for controlled drug delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Faith Seke, Vimbainashe E. Manhivi, Retha M. Slabbert, Yasmina Sultanbawa, Dharini Sivakumar
Summary: This study aimed to improve the bioaccessibility of anthocyanins in Natal plum by using microencapsulation techniques. The highest encapsulation efficiency and anthocyanin bioaccessibility were achieved with alginate/psyllium mucilage beads.
Article
Chemistry, Applied
Jingyi Yang, Jiangliu Song, Song Miao, Yanxiang Gao, Like Mao
Summary: This study developed novel gel beads with bigel structures based on alginate hydrogel and glycerol monostearate oleogel. The beads were able to encapsulate lipophilic and hydrophilic bioactives simultaneously. The increase in oleogel content led to larger bead size, higher oil filling level, and lower mechanical strength. The swelling of beads was inhibited by the increase in oleogel content. The gel structures provided good protection for curcumin, and about 70% of the original curcumin was retained after a 40-day storage test. The study provided valuable information for the development of functional food materials.
FOOD HYDROCOLLOIDS
(2024)
Article
Biochemistry & Molecular Biology
Emine Bulut
Summary: The study focused on the preparation of ionically crosslinked beads as semi-interpenetrating polymer networks loaded with ibuprofen. The drug release behaviors and performance parameters of the beads were investigated and optimized for the best release conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Han, Jiao Sun, Peter A. Williams, Jixin Yang, Shubiao Zhang
Summary: The solubilization and targeted delivery of hydrophobic anti-cancer drugs using sugar-based micelles have shown promising results in inhibiting tumor growth and reducing systemic toxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Alejandro Londono-Moreno, Zayra Mundo-Franco, Margarita Franco-Colin, Carolina Buitrago-Arias, Martha Lucia Arenas-Ocampo, Antonio Ruperto Jimenez-Aparicio, Edgar Cano-Europa, Brenda Hildeliza Camacho-Diaz
Summary: The aim of this study was to develop a microencapsulate of a complex matrix using polysaccharides to protect and control the release of CPC. The results showed that the encapsulation efficiency of the matrix-type encapsulates increased as more components were added to the mixtures. Therefore, matrix M4 exhibited an encapsulation efficiency for CPC of 98% and a bioaccessibility of 10.65 +/- 0.65% after the passage of encapsulates through in vitro digestion.
Article
Nanoscience & Nanotechnology
Tianzi Geng, Lining Zhao, Di Wu, Hongxin Zhang, Xiaolong Zhao, Meng Jiao, Leyong Zeng
Summary: In this study, ultrasmall AuNC bombined with BSA nanospheres to form stable and biocompatible AuNCs@BSA nanoprobes, which showed enhanced fluorescence emission and singlet oxygen yield compared to single AuNCs. The nanoprobes exhibited lower cytotoxicity, stronger cellular uptake, and significantly improved cell viability and tumor elimination in PDT applications. The results demonstrated that AuNCs@BSA;nanoprobes have great potential for efficient PDT due to their safety and reliability.
ACS APPLIED NANO MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Ivana M. Savic Gajic, Ivan M. Savic, Dragoljub G. Gajic, Aleksandar Dosic
Summary: This study aimed to develop an ultrasound-assisted extraction method for carotenoids from orange peel using olive oil as a solvent, finding optimal extraction conditions and preparing stable Ca-alginate beads enriched with carotenoids in olive oil. The results indicated that extraction time had the greatest impact on carotenoid content.
Article
Agriculture, Multidisciplinary
Kyria Boundy-Mills, Nardrapee Karuna, L. Antonio Garay, Julian M. Lopez, Calvin Yee, Alex Hitomi, Audry K. Nishi, Lauren L. Enriquez, Christopher Roberts, David E. Block, Tina Jeoh
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2019)
Article
Pharmacology & Pharmacy
Scott A. Strobel, Herbert B. Scher, Nitin Nitin, Tina Jeoh
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Food Science & Technology
Amna Javed, Annie J. King, Muhammad Imran, Tina Jeoh, Sadia Naseem
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2019)
Article
Marine & Freshwater Biology
Sergio P. Barahona, Ximena Velez-Zuazo, Monica Santa-Maria, Aldo S. Pacheco
MARINE ECOLOGY-AN EVOLUTIONARY PERSPECTIVE
(2019)
Article
Biotechnology & Applied Microbiology
Akshata R. Mudinoor, Peter M. Goodwin, Raghavendra U. Rao, Nardrapee Karuna, Alex Hitomi, Jennifer Nill, Tina Jeoh
BIOTECHNOLOGY FOR BIOFUELS
(2020)
Article
Food Science & Technology
Scott A. Strobel, Kevin Hudnall, Benjamin Arbaugh, Julia C. Cunniffe, Herbert B. Scher, Tina Jeoh
FOOD AND BIOPROCESS TECHNOLOGY
(2020)
Article
Food Science & Technology
Yuting Tang, Herbert B. Scher, Tina Jeoh
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2020)
Article
Engineering, Chemical
Scott A. Strobel, Lucille Knowles, Nitin Nitin, Herbert B. Scher, Tina Jeoh
JOURNAL OF FOOD ENGINEERING
(2020)
Article
Engineering, Chemical
Shan Huang, Scott A. Strobel, Rewa Rai, Tina Jeoh, Nitin Nitin
JOURNAL OF FOOD ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Jennifer Danger Nill, Tina Jeoh
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Chemistry, Multidisciplinary
Dana E. Wong, Julia C. Cunniffe, Herbert B. Scher, Tina Jeoh
Article
Multidisciplinary Sciences
Tina Jeoh, Dana E. Wong, Scott A. Strobel, Kevin Hudnall, Nadia R. Pereira, Kyle A. Williams, Benjamin M. Arbaugh, Julia C. Cunniffe, Herbert B. Scher
Summary: This study demonstrates that alginate gel rapidly under ambient conditions through calcium mediated electrostatic crosslinks, forming protective matrices for sensitive bioactive cargo. The crosslinking in CLAMs plays a crucial role in determining its barrier properties and applications in food, cosmetics, and agriculture. The extent of gelation in spray dried CLAMs can be controlled by the molecular weights of the alginates at saturating calcium concentrations.
Article
Fisheries
Ximena Velez-Zuazo, Sergio P. Barahona, Omar G. Melo, Eric Hanschke, Ian Hanschke, Monica C. Santa-Maria
Summary: The study revealed no spatial divergence among Peruvian scallop populations, but a strong differentiation with the Chilean population. Migration rate estimates suggested asymmetric directionality of seed translocation, supporting a remnant effect of intense historic translocation and ongoing gene flow among wild populations in Peru.
JOURNAL OF THE WORLD AQUACULTURE SOCIETY
(2022)
Article
Multidisciplinary Sciences
Alonso Reyes-Calderon, Elias Mindreau-Ganoza, Braulio Pardo-Figueroa, Katherine R. Garcia-Luquillas, Sonia P. Yufra, Pedro E. Romero, Claudia Antonini, Jose-Miguel Renom, Cesar R. Mota, Monica C. Santa-Maria
Summary: Wastewater-Based Epidemiology (WBE) is a method that quantifies biomarkers in sewerage systems to obtain real-time information on the health and lifestyle of the population. This study evaluates low-cost methods for SARS-CoV-2 RNA quantification and variant identification in wastewater samples. The results suggest the use of a robust and cost-effective method for SARS-CoV-2 RNA analysis that could be implemented for other viruses.
Article
Nanoscience & Nanotechnology
Alixander Perzon, Benedikt M. Blossom, Claus Felby, Tina Jeoh, Alex Hitomi, Peter Ulvskov, Bodil Jorgensen
ACS APPLIED NANO MATERIALS
(2020)