Article
Biochemistry & Molecular Biology
Young Min Kim, Kyungsene Lee, Yuyeon Lee, Kyungjik Yang, Deokyeong Choe, Young Hoon Roh
Summary: In this study, thermoresponsive gelatin-alginate hybrid hydrogels and microcapsules were used to control the release of scent molecules from plant-based meats, providing a potential solution for enhancing market acceptance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Huazhong Ma, Jianglin Zhao, Ying Liu, Liang Liu, Juan Yu, Yimin Fan
Summary: An interpenetrating network (IPN) hydrogel was developed by crosslinking nanocellulose and sodium alginate through an acetic acid coagulation bath and Ca2+ chelation. The nanofibers in the hydrogel greatly extended the release time of aspirin to 60 hours, thanks to the well-structured network. Carboxyl groups played a role in the release capacity in different pH environments. This study provides a guide for the preparation of physically crosslinked IPN hydrogels with good mechanical properties and cytocompatibility for drug delivery applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Polymer Science
Guelsen Taskin Cakici
Summary: This study evaluated the in vitro release of 5-fluorouracil for the transdermal delivery system of NaAlg/HPMC/TiO2 biocompatible membranes. The nanocomposite membrane was prepared by adding TiO2 nanoparticles to a mixture of sodium alginate and hydroxypropyl methylcellulose polymers. The membranes were analyzed using various techniques, and the effects of crosslinking time, nanoparticle amount, and temperature on drug release were investigated. The release kinetics of 5-fluorouracil from NaAlg/HPMC/TiO2 membranes conformed to the Korsmeyer-Pappes model.
Article
Chemistry, Physical
Kyung Hee Park, Yeon Woo Choi, Heejoo Ryu, Hyoung Jae Lee, Jae-Hak Moon, Ho-Jun Song, Yeong-Joon Park
Summary: This study developed improved multi-component beads for controlled and sustained delivery of antibiotics. Single and multi-component beads were prepared using chitosan, calcium chloride, alginate, and citric acid, and the release of antibiotics was controlled by crosslinking. The crosslinked beads showed efficient sustained-release of gentamicin.
Article
Agriculture, Multidisciplinary
Yang Yang, Can Zhang, Xin Bian, Li-kun Ren, Chun-min Ma, Yue Xu, Dan Su, Lian-zhong Ai, Ming-feng Song, Na Zhang
Summary: This study prepared edible soy protein isolate (SPI) and sodium alginate (SA) interpenetrating polymer network (IPN) hydrogels using enzymatic and Ca2+ cross-linking methods, overcoming the disadvantages of traditional IPN hydrogels. The influence of changes in SPI and SA mass ratio on the performance of SPI-SA IPN hydrogels was investigated.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Polymer Science
Kasra Yari, Iman Akbari, Hossein Baniasadi
Summary: In this study, ibuprofen nanoparticles (Ibp NPs) with a particle size of less than 50 nm were synthesized and loaded into sodium alginate/psyllium seed mucilage (SA/PSM) carriers for a controlled drug release. The results showed that the SA/PSM beads had low swelling and release in acidic medium, and the drug release followed Fickian diffusion mechanism type.
Article
Chemistry, Applied
Xiang Xu, Linghan Meng, Chengcheng Gao, Weiwei Cheng, Yuling Yang, Xinchun Shen, Xiaozhi Tang
Summary: The effects of different concentrations and crosslinking methods of sodium alginate (SA) on the structure, cooking quality and in vitro starch digestibility of extruded whole buckwheat noodles were investigated. The addition of 1% SA significantly improved the cooking quality and reduced starch digestibility of the noodles, while the use of crosslinking methods further enhanced these properties by forming a Starch-SA interpenetrating polymer network (IPN).
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Applied
Ning Yang, Yali Huang, Jingwen Hou, Yaqiong Zhang, Liu Tian, Zhaoyang Chen, Zhu Jin, Yuanyuan Shen, Shengrong Guo
Summary: The study found that the semi-interpenetrating networks of HPMC and gellan exhibited strong gel states at 50°C and weak gel states at 20°C. The addition of gellan in aqueous systems containing 20% HPMC led to increased elasticity, hardness, fracturability, adhesiveness, and tensile strength of the gels. The combination of HPMC and gellan resulted in gel systems with more adjustable and enhanced rheological behaviors and texture properties in comparison to HPMC alone.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Applied
Furui He, Longzheng Wang, Shujuan Yang, Wenqi Qin, Yuhong Feng, Yuanyuan Liu, Yang Zhou, Gaobo Yu, Jiacheng Li
Summary: In this study, a highly stretchable and tough interpenetrating composite hydrogel with self-repairing behavior under light irradiation was successfully fabricated. The self-healing behavior of the gel is achieved through the host-guest interaction between cyclodextrin and azobenzene, enabling significant recovery of gel elongation within 48 hours under dark conditions. This gel demonstrates the ability to achieve self-healing while maintaining highly stretchable and tough performance.
CARBOHYDRATE POLYMERS
(2021)
Article
Food Science & Technology
Rui Cui, Bifen Zhu, Jiatong Yan, Yuyue Qin, Mingwei Yuan, Guiguang Cheng, Minglong Yuan
Summary: The study prepared antimicrobial food packaging film with controlled release by loading cinnamaldehyde on etched halloysite nanotubes and adding it to sodium alginate matrix. The film showed improved water vapor barrier properties, tensile strength, and reduced negative effects of UV rays. Controlled release of cinnamaldehyde in the film was confirmed, suggesting broad application prospects in fatty food packaging.
Article
Biochemistry & Molecular Biology
Chen Chen, Enhui He, Weina Jia, Shuwei Xia, Liangmin Yu
Summary: In this study, a novel magnetic adsorbent material Fe3O4@SA/CMC-Fe was successfully synthesized for efficient adsorption of dye wastewater. The Fe3O4@SA/CMC-Fe exhibited high adsorption efficiency for dye wastewater, and the adsorption mechanism involved hydrogen bonding, complexation, and electrostatic adsorption.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jeong Woo Lee, Jiwoo Han, Yong-Keun Choi, Saerom Park, Sang Hyun Lee
Summary: Alginate composite beads containing activated carbon (AC) and carboxymethyl cellulose (CMC) were prepared as reswellable hydrogels with enhanced adsorption capacity for ibuprofen. The dried Alg/AC/CMC beads could be recovered to their initial hydrogel state, while the dried Alg/AC beads without CMC could not. The reswelled Alg/AC/CMC beads showed an 86% recovery in the adsorption capacity for ibuprofen compared to the initial hydrogel beads, whereas the reswelled Alg/AC beads only exhibited 18% of the initial adsorption capacity. The effects of CMC substitution degree, AC content, and solution pH on the reswelling property and ibuprofen adsorption capacity of the Alg/AC/CMC beads were investigated. The prepared composite beads exhibited pseudosecond-order kinetics and Langmuir isotherms in the hydrogel and reswelled states, respectively. Additionally, the reswelled Alg composite beads maintained high adsorption capacity (>93%) after multiple cycles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kun Fang, Yuqi Zhang, Jiangyu Yin, Tonghan Yang, Kai Li, Li Wei, Jianbin Li, Wei He
Summary: In this study, pH-responsive and magnetic carboxymethyl starch/alginate hydrogel beads were developed as potential drug carriers for controlled release of anticancer drug. The beads demonstrated excellent stability in simulated stomach fluids and sustained release in simulated intestinal fluids. Applying an external magnetic field enhanced drug release. The beads showed significant cytotoxicity to colon cancer cell lines while having no harmful effects on normal cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mohamed Abdin, Mostafa Mabrouk, Laila El-Sebaiy, Maher Eissa, Mohamed El-Bana, Mohamed Abdelbaset Salama, A. E. El-Beltagy, Mohamed Ahmed Naeem
Summary: The study aimed to develop biodegradable films using carboxymethyl cellulose (CMC), sodium alginate (SA), and Thymus vulgaris purified leaves extract (TVE). The addition of TVE up to 1.6% in the film matrix increased opacity, reduced moisture, swelling, solubility, and water vapor permeability (WVP). The surface micrographs showed smoother surface at low TVE concentrations and became irregular and rough at higher concentrations. The developed CMC/SA/TVE2 film showed significant effects on preserving the quality of cheddar cheese during cold storage compared to commercial packaging materials.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
O. Sreekanth Reddy, M. C. S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao
Summary: The aim of this study was to fabricate dual cross linked sodium alginate/montmorillonite microbeads as a potential drug carrier for extended release of curcumin. Characterization of the microbeads was done using FTIR, DSC, TGA, X-RD, and SEM. The swelling and in vitro release studies of the microbeads were influenced by the pH of test media, indicating their potential for intestinal drug delivery.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)