Defects in cholesterol synthesis genes in mouse and in humans: lessons for drug development and safer treatments

Cholesterol Lowering, Cardiovascular Diseases, and the Rosuvastatin-JUPITER Controversy

(2010) Michel de Lorgeril   ARCHIVES OF INTERNAL MEDICINE

Interplay between cholesterol and drug metabolism

(2010) Tadeja Rezen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Intratumoral Estrogen Disposition in Breast Cancer

(2010) B. P. Haynes et al.   CLINICAL CANCER RESEARCH

Hydroxysteroid (17β) Dehydrogenase 7 Activity Is Essential for Fetalde NovoCholesterol Synthesis and for Neuroectodermal Survival and Cardiovascular Differentiation in Early Mouse Embryos

(2010) Heli Jokela et al.   ENDOCRINOLOGY

Effects of Toremifene and Tamoxifen on Lipid Profiles in Post-menopausal Patients with Early Breast Cancer: Interim Results from a Japanese Phase III Trial

(2010) T. Tominaga et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels

(2010) M. Lauth et al.   MOLECULAR PHARMACOLOGY

The chemical toolbox for monitoring protein fatty acylation and prenylation

(2010) Rami N Hannoush et al.   Nature Chemical Biology

Targeting farnesyl-transferase as a novel therapeutic strategy for mevalonate kinase deficiency: In vitro and in vivo approaches

(2010) Luigina De Leo et al.   PHARMACOLOGICAL RESEARCH

Perspectives of the non-statin hypolipidemic agents

(2010) Damjana Rozman et al.   PHARMACOLOGY & THERAPEUTICS

Requirement of DHCR24 for Postnatal Development of Epidermis and Hair Follicles in Mice

(2009) Rusella Mirza et al.   AMERICAN JOURNAL OF DERMATOPATHOLOGY

New insights on the neuroprotective role of sterols and sex steroids: The seladin-1/DHCR24 paradigm

(2009) Alessandro Peri et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Significant contributions of the extraembryonic membranes and maternal genotype to the placental pathology in heterozygous Nsdhl deficient female embryos

(2009) David Cunningham et al.   HUMAN MOLECULAR GENETICS

Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells

(2009) Jure Acimovic et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the Golden Syrian hamster

(2009) Katie T. Burke et al.   JOURNAL OF LIPID RESEARCH

Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells

(2009) Nicolas Parent et al.   Journal of Proteomics

Trafficking, development and hedgehog

(2009) Fiona Simpson et al.   MECHANISMS OF DEVELOPMENT

Induction of a Massive Endoplasmic Reticulum and Perinuclear Space Expansion by Expression of Lamin B Receptor Mutants and the Related Sterol Reductases TM7SF2 and DHCR7

(2009) Monika Zwerger et al.   MOLECULAR BIOLOGY OF THE CELL

CREM modulates the circadian expression of CYP51, HMGCR and cholesterogenesis in the liver

(2008) Jure Acimovic et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biochemical and Structural Basis for Feedback Inhibition of Mevalonate Kinase and Isoprenoid Metabolism†,‡

(2008) Zhuji Fu et al.   BIOCHEMISTRY

Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice

(2008) R. Mirza et al.   BRITISH JOURNAL OF DERMATOLOGY

Drug Interaction Potential of 2-((3,4-Dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the Novel Nonstatin-Type Cholesterol-Lowering Agent

(2008) K. Monostory et al.   DRUG METABOLISM AND DISPOSITION

Smith–Lemli–Opitz syndrome: pathogenesis, diagnosis and management

(2008) Forbes D Porter   EUROPEAN JOURNAL OF HUMAN GENETICS

Emerging lipid-lowering drugs: squalene synthase inhibitors

(2008) Raghda K Elsayed et al.   EXPERT OPINION ON EMERGING DRUGS

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Toremifene Improves Lipid Profiles in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer: Interim Analysis of a Multicenter Phase III Study

(2008) Matthew R. Smith et al.   JOURNAL OF CLINICAL ONCOLOGY

Prolactin Receptor-Associated Protein/17β-Hydroxysteroid Dehydrogenase Type 7 Gene (Hsd17b7) Plays a Crucial Role in Embryonic Development and Fetal Survival

(2008) Aurora Shehu et al.   MOLECULAR ENDOCRINOLOGY

Precholesterol Sterols Accumulate in Lipid Rafts of Patients with Smith-Lemli-Opitz Syndrome and X-Linked Dominant Chondrodysplasia Punctata

(2008) Dinesh Rakheja et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Prenatal exposure to HMG-CoA reductase inhibitors: Effects on fetal and neonatal outcomes

(2008) Nobuko Taguchi et al.   REPRODUCTIVE TOXICOLOGY

Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations

(2008) Alessandro Pedretti et al.   STEROIDS

Squalene in a sex-dependent manner modulates atherosclerotic lesion which correlates with hepatic fat content in apoE-knockout male mice

(2007) Natalia Guillén et al.   ATHEROSCLEROSIS

Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51)

(2007) Tina Korošec et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Oxysterols: Novel biologic roles for the 21st century

(2007) Norman B. Javitt   STEROIDS

Lathosterol side chain amides—A new class of human lathosterol oxidase inhibitors

(2007) Martin Giera et al.   STEROIDS