The Intestinal Virome and Immunity

Using Metagenomics to Characterize an Expanding Virosphere

(2018) Yong-Zhen Zhang et al.   CELL

Bacteria Facilitate Enteric Virus Co-infection of Mammalian Cells and Promote Genetic Recombination

(2018) Andrea K. Erickson et al.   Cell Host & Microbe

Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes

(2018) Geicho Nakatsu et al.   GASTROENTEROLOGY

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

(2018) Craig B. Wilen et al.   SCIENCE

Neoadjuvant oncolytic virotherapy before surgery sensitizes triple-negative breast cancer to immune checkpoint therapy

(2018) Marie-Claude Bourgeois-Daigneault et al.   Science Translational Medicine

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

(2018) Adel Samson et al.   Science Translational Medicine

Distinct Effects of Type I and III Interferons on Enteric Viruses

(2018) Harshad Ingle et al.   Viruses-Basel

Enteric Virome Sensing—Its Role in Intestinal Homeostasis and Immunity

(2018) Rebecca Metzger et al.   Viruses-Basel

Together Forever: Bacterial–Viral Interactions in Infection and Immunity

(2018) et al.   Viruses-Basel

Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection

(2017) Stephan J. Ott et al.   GASTROENTEROLOGY

Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome

(2017) Tao Zuo et al.   GUT

Differentiation and Protective Capacity of Virus-Specific CD8 + T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche

(2017) Vesselin T. Tomov et al.   IMMUNITY

Viral infections in allergy and immunology: How allergic inflammation influences viral infections and illness

(2017) Michael R. Edwards et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

(2017) Megan T. Baldridge et al.   JOURNAL OF VIROLOGY

Rhinovirus C, Asthma, and Cell Surface Expression of Virus Receptor CDHR3

(2017) Ann C. Palmenberg   JOURNAL OF VIROLOGY

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

(2017) Shu Zhu et al.   NATURE

The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease

(2017) Jérôme Legoff et al.   NATURE MEDICINE

Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer

(2017) George Kassiotis et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children

(2017) Guoyan Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease

(2017) Romain Bouziat et al.   SCIENCE

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury

(2017) Julius C. Fischer et al.   Science Translational Medicine

Origins and challenges of viral dark matter

(2017) Siddharth R. Krishnamurthy et al.   VIRUS RESEARCH

The Human Gut Phage Community and Its Implications for Health and Disease

(2017) Pilar Manrique et al.   Viruses-Basel

The blood DNA virome in 8,000 humans

(2017) Ahmed Moustafa et al.   PLoS Pathogens

Microbes and Viruses Are Bugging the Gut in Celiac Disease. Are They Friends or Foes?

(2017) Aaron Lerner et al.   Frontiers in Microbiology

Type I and III Interferon in the Gut: Tight Balance between Host Protection and Immunopathology

(2017) Johanna Pott et al.   Frontiers in Immunology

The major targets of acute norovirus infection are immune cells in the gut-associated lymphoid tissue

(2017) Katrina R. Grau et al.   Nature Microbiology

Discovery of an expansive bacteriophage family that includes the most abundant viruses from the human gut

(2017) Natalya Yutin et al.   Nature Microbiology

Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas

(2017) Virginie S.E. Jean-Baptiste et al.   EBioMedicine

Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome

(2016) Cynthia L. Monaco et al.   Cell Host & Microbe

Intrinsic Defense Mechanisms of the Intestinal Epithelium

(2016) Deepshika Ramanan et al.   Cell Host & Microbe

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production

(2016) Jin-Young Yang et al.   IMMUNITY

Rhinovirus-associated pulmonary exacerbations show a lack of FEV1improvement in children with cystic fibrosis

(2016) Mathias Cousin et al.   Influenza and Other Respiratory Viruses

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

(2016) James A. Pearson et al.   JOURNAL OF AUTOIMMUNITY

Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis

(2016) Cristina Hernández-Chirlaque et al.   Journal of Crohns & Colitis

The influence of commensal bacteria on infection with enteric viruses

(2016) Stephanie M. Karst   NATURE REVIEWS MICROBIOLOGY

Frequency and Duration of Rhinovirus Infections in Children With Cystic Fibrosis and Healthy Controls

(2016) Jasper S. Dijkema et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

TLR-7 activation enhances IL-22–mediated colonization resistance against vancomycin-resistant enterococcus

(2016) Michael C. Abt et al.   Science Translational Medicine

Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling

(2016) Jessica A. Pane et al.   Scientific Reports

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair

(2015) Lulu Sun et al.   Cell Host & Microbe

Innate Susceptibility to Norovirus Infections Influenced by FUT2 Genotype in a United States Pediatric Population

(2015) Rebecca L. Currier et al.   CLINICAL INFECTIOUS DISEASES

The Virome in Host Health and Disease

(2015) Ken Cadwell   IMMUNITY

Activation of the innate immune response by endogenous retroviruses

(2015) Tara P. Hurst et al.   JOURNAL OF GENERAL VIROLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Early life dynamics of the human gut virome and bacterial microbiome in infants

(2015) Efrem S Lim et al.   NATURE MEDICINE

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

(2015) Yury A. Bochkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nlrp6 regulates intestinal antiviral innate immunity

(2015) Penghua Wang et al.   SCIENCE

Comprehensive serological profiling of human populations using a synthetic human virome

(2015) G. J. Xu et al.   SCIENCE

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection

(2015) Donna A MacDuff et al.   eLife

Bacterial Lipopolysaccharide Binding Enhances Virion Stability and Promotes Environmental Fitness of an Enteric Virus

(2014) Christopher M. Robinson et al.   Cell Host & Microbe

Inflammatory Bowel Disease as a Model for Translating the Microbiome

(2014) Curtis Huttenhower et al.   IMMUNITY

Norovirus Triggered Microbiota-driven Mucosal Inflammation in Interleukin 10-deficient Mice

(2014) Marijana Basic et al.   INFLAMMATORY BOWEL DISEASES

Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients

(2014) Anne Goffard et al.   JOURNAL OF CLINICAL VIROLOGY

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell–dependent inflammation

(2014) Jian Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibiotic Treatment Suppresses Rotavirus Infection and Enhances Specific Humoral Immunity

(2014) Robin Uchiyama et al.   JOURNAL OF INFECTIOUS DISEASES

Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status

(2014) Ben A. Lopman et al.   JOURNAL OF INFECTIOUS DISEASES

An enteric virus can replace the beneficial function of commensal bacteria

(2014) Elisabeth Kernbauer et al.   NATURE

Commensal bacteria protect against food allergen sensitization

(2014) A. T. Stefka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18

(2014) B. Zhang et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

Enteric bacteria promote human and mouse norovirus infection of B cells

(2014) M. K. Jones et al.   SCIENCE

A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes

(2014) Bas E. Dutilh et al.   Nature Communications

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

(2014) Jessica A. Pane et al.   PLoS Pathogens

Coxsackievirus B1 Is Associated With Induction of  -Cell Autoimmunity That Portends Type 1 Diabetes

(2013) O. H. Laitinen et al.   DIABETES

Describing the Silent Human Virome with an Emphasis on Giant Viruses

(2013) Nikolay Popgeorgiev et al.   INTERVIROLOGY

Persistent Enteric Murine Norovirus Infection Is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses

(2013) V. T. Tomov et al.   JOURNAL OF VIROLOGY

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Control of pathogens and pathobionts by the gut microbiota

(2013) Nobuhiko Kamada et al.   NATURE IMMUNOLOGY

Rapid evolution of the human gut virome

(2013) S. Minot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Enterovirus Species B in Ileocecal Crohn’s Disease

(2013) Niklas Nyström et al.   Clinical and Translational Gastroenterology

Pathogenic Simian Immunodeficiency Virus Infection Is Associated with Expansion of the Enteric Virome

(2012) Scott A. Handley et al.   CELL

Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes

(2012) J. A. Pane et al.   DIABETOLOGIA

Adaptive Immunity Restricts Replication of Novel Murine Astroviruses

(2012) C. C. Yokoyama et al.   JOURNAL OF VIROLOGY

Norovirus Gastroenteritis in Immunocompromised Patients

(2012) Karin Bok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

(2011) Tina Herbst et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diversity and Abundance of Single-Stranded DNA Viruses in Human Feces

(2011) Min-Soo Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Norovirus gastroenteritis causes severe and lethal complications after chemotherapy and hematopoietic stem cell transplantation

(2011) S. Schwartz et al.   BLOOD

The human gut virome: Inter-individual variation and dynamic response to diet

(2011) S. Minot et al.   GENOME RESEARCH

Mitochondrial antiviral signaling protein (MAVS) monitors commensal bacteria and induces an immune response that prevents experimental colitis

(2011) X.-D. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful Transmission of a Retrovirus Depends on the Commensal Microbiota

(2011) M. Kane et al.   SCIENCE

Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis

(2011) S. K. Kuss et al.   SCIENCE

Viruses, Autophagy Genes, and Crohn’s Disease

(2011) Vanessa M. Hubbard et al.   Viruses-Basel

Latent herpesvirus infection arms NK cells

(2010) D. W. White et al.   BLOOD

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

Prevalence and characteristics of asymptomatic norovirus infection in the community in England

(2010) G. PHILLIPS et al.   EPIDEMIOLOGY AND INFECTION

Association between human rhinovirus C and severity of acute asthma in children

(2010) J. Bizzintino et al.   EUROPEAN RESPIRATORY JOURNAL

RIG-I/MDA5/MAVS Are Required To Signal a Protective IFN Response in Rotavirus-Infected Intestinal Epithelium

(2010) A. H. Broquet et al.   JOURNAL OF IMMUNOLOGY

Viruses in the faecal microbiota of monozygotic twins and their mothers

(2010) Alejandro Reyes et al.   NATURE

Transfusion transmission of highly prevalent commensal human viruses

(2010) Flavien Bernardin et al.   TRANSFUSION

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Metagenomic Analysis of Respiratory Tract DNA Viral Communities in Cystic Fibrosis and Non-Cystic Fibrosis Individuals

(2009) Dana Willner et al.   PLoS One

Antibody Is Critical for the Clearance of Murine Norovirus Infection

(2008) K. A. Chachu et al.   JOURNAL OF VIROLOGY

Rotavirus Infection Accelerates Type 1 Diabetes in Mice with Established Insulitis

(2008) K. L. Graham et al.   JOURNAL OF VIROLOGY

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection

(2008) Karen A. Chachu et al.   PLoS Pathogens

MDA-5 Recognition of a Murine Norovirus

(2008) Stephen A. McCartney et al.   PLoS Pathogens