Multivalent DNA recognition by self-assembled clusters: deciphering structural effects by fragments screening and evaluation as siRNA vectors

Bioinspired Therapeutic Dendrimers as Efficient Peptide Drugs Based on Supramolecular Interactions for Tumor Inhibition

(2015) Xiao Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic Expression of DNA Complexation with Self-assembled Biomolecular Clusters

(2015) Eline Bartolami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cellular uptake: lessons from supramolecular organic chemistry

(2015) Giulio Gasparini et al.   CHEMICAL COMMUNICATIONS

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

(2015) Ulrich Lächelt et al.   CHEMICAL REVIEWS

The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

(2015) Pavel L. Padnya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems

(2014) Xiaoxuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cationic Vesicles Based on Amphiphilic Pillar[5]arene Capped with Ferrocenium: A Redox-Responsive System for Drug/siRNA Co-Delivery

(2014) Yincheng Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity

(2014) H. L. Cao et al.   CHEMICAL COMMUNICATIONS

Degradable Hybrid Materials Based on Cationic Acylhydrazone Dynamic Covalent Polymers Promote DNA Complexation through Multivalent Interactions

(2014) Camille Bouillon et al.   CHEMISTRY-A EUROPEAN JOURNAL

A releasable disulfide carbonate linker for polyethyleneimine (PEI)-based gene vectors

(2014) Liandong Feng et al.   NEW JOURNAL OF CHEMISTRY

Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin

(2014) Yi-Chao Huang et al.   TETRAHEDRON

Utilizing Combinatorial Chemistry and Rational Design: Peptidic Tweezers with Nanomolar Affinity to DNA Can Be Transformed into Efficient Vectors for Gene Delivery by Addition of a Lipophilic Tail

(2013) Hannes Y. Kuchelmeister et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanostructures of Cationic Amphiphilic Cyclodextrin Complexes with DNA

(2013) Valentina Villari et al.   BIOMACROMOLECULES

A bioreducible linear poly(β-amino ester) for siRNA delivery

(2013) Kristen L. Kozielski et al.   CHEMICAL COMMUNICATIONS

Polycationic Pillar[5]arene Derivatives: Interaction with DNA and Biological Applications

(2013) Iwona Nierengarten et al.   CHEMISTRY-A EUROPEAN JOURNAL

Amphiphilic Oligoethyleneimine−β-Cyclodextrin “Click” Clusters for Enhanced DNA Delivery

(2013) Álvaro Martínez et al.   JOURNAL OF ORGANIC CHEMISTRY

Dynamic Amphiphile Libraries To Screen for the “Fragrant” Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts

(2013) Charlotte Gehin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Degradable Polymer-Caged Lipoplex (PCL) Platform for siRNA Delivery: Facile Cellular Triggered Release of siRNA

(2013) Bong Jin Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double-degradable responsive self-assembled multivalent arrays – temporary nanoscale recognition between dendrons and DNA

(2013) Anna Barnard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Arginine clustering on calix[4]arene macrocycles for improved cell penetration and DNA delivery

(2013) Valentina Bagnacani et al.   Nature Communications

Polyspermine Imidazole-4,5-imine, a Chemically Dynamic and Biologically Responsive Carrier System for Intracellular Delivery of siRNA

(2012) Shiyue Duan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lower Rim Guanidinocalix[4]arenes: Macrocyclic Nonviral Vectors for Cell Transfection

(2012) Valentina Bagnacani et al.   BIOCONJUGATE CHEMISTRY

Acid-degradable polymers for drug delivery: a decade of innovation

(2012) Sandra Binauld et al.   CHEMICAL COMMUNICATIONS

Cationic polymers and their therapeutic potential

(2012) Sangram Keshari Samal et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of an Enlarged Library of Dynamic DNA Activators with Oxime, Disulfide and Hydrazone Bridges

(2012) Javier Montenegro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA

(2012) Lina Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfide Cross-Linked Low Generation Dendrimers with High Gene Transfection Efficacy, Low Cytotoxicity, and Low Cost

(2012) Hongmei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties

(2012) Céline Bienvenu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioreducible Polymers for Gene Silencing and Delivery

(2011) Sejin Son et al.   ACCOUNTS OF CHEMICAL RESEARCH

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Gene delivery with polycationic fullerene hexakis-adducts

(2011) David Sigwalt et al.   CHEMICAL COMMUNICATIONS

β-Cyclodextrin-Based Polycationic Amphiphilic “Click” Clusters: Effect of Structural Modifications in Their DNA Complexing and Delivery Properties

(2011) Alejandro Méndez-Ardoy et al.   JOURNAL OF ORGANIC CHEMISTRY

Degradable Self-Assembling Dendrons for Gene Delivery: Experimental and Theoretical Insights into the Barriers to Cellular Uptake

(2011) Anna Barnard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrophobically Modified Dendrons: Developing Structure−Activity Relationships for DNA Binding and Gene Transfection

(2011) Simon P. Jones et al.   MOLECULAR PHARMACEUTICS

Differences in DNA Condensation and Release by Lysine and Arginine Homopeptides Govern Their DNA Delivery Efficiencies

(2011) Anita Mann et al.   MOLECULAR PHARMACEUTICS

Dendrimers as non-viral vectors for siRNA delivery

(2011) Xiaoxuan Liu et al.   NEW JOURNAL OF CHEMISTRY

Comprehensive screening of octopus amphiphiles as DNA activators in lipid bilayers: implications on transport, sensing and cellular uptake

(2011) Javier Montenegro et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Protein–dendron conjugates for DNA binding: understanding the effect of the protein core on multivalency

(2011) Giovanni M. Pavan et al.   RSC Advances

Reduction-Degradable Linear Cationic Polymers as Gene Carriers Prepared by Cu(I)-Catalyzed Azide−Alkyne Cycloaddition

(2010) Yang Wang et al.   BIOMACROMOLECULES

RNA interference: a chemist's perspective

(2010) James W. Gaynor et al.   CHEMICAL SOCIETY REVIEWS

Dynamic Octopus Amphiphiles as Powerful Activators of DNA Transporters: Differential Fragrance Sensing and Beyond

(2010) Javier Montenegro et al.   CHEMISTRY-A EUROPEAN JOURNAL

Calixarenes: from biomimetic receptors to multivalent ligands for biomolecular recognition

(2010) Francesco Sansone et al.   NEW JOURNAL OF CHEMISTRY

Specificity landscapes of DNA binding molecules elucidate biological function

(2010) C. D. Carlson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Less is more – multiscale modelling of self-assembling multivalency and its impact on DNA binding and gene delivery

(2010) Paola Posocco et al.   Chemical Science

Delivery of Nucleic Acids via Disulfide-Based Carrier Systems

(2009) Sonja Bauhuber et al.   ADVANCED MATERIALS

“On-Off” Multivalent Recognition: Degradable Dendrons for Temporary High-Affinity DNA Binding

(2009) Daniel J. Welsh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems

(2009) Tae-il Kim et al.   BIOMATERIALS

CSI–FID: High throughput label-free detection of DNA binding molecules

(2009) Karl E. Hauschild et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Polycationic Amphiphilic Cyclodextrins for Gene Delivery: Synthesis and Effect of Structural Modifications on Plasmid DNA Complex Stability, Cytotoxicity, and Gene Expression

(2009) Alejandro Díaz-Moscoso et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modeling the Multivalent Recognition between Dendritic Molecules and DNA: Understanding How Ligand “Sacrifice” and Screening Can Enhance Binding

(2009) Giovanni M. Pavan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

Synergistic effects on gene delivery – co-formulation of small disulfide-linked dendritic polycations with Lipofectamine 2000™

(2009) John G. Hardy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Polymeric Materials for Gene Delivery and DNA Vaccination

(2008) David N. Nguyen et al.   ADVANCED MATERIALS

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

(2008) Alejandro Díaz-Moscoso et al.   CHEMICAL COMMUNICATIONS

Synergistic effects in gene delivery—a structure–activity approach to the optimisation of hybrid dendritic–lipidic transfection agents

(2008) Simon P. Jones et al.   CHEMICAL COMMUNICATIONS

Nonviral Vectors for Gene Delivery

(2008) Meredith A. Mintzer et al.   CHEMICAL REVIEWS

1-Ethoxyethylidene, a New Group for the Stepwise SPPS of Aminooxyacetic Acid Containing Peptides

(2008) Stéphanie Foillard et al.   JOURNAL OF ORGANIC CHEMISTRY

Tailoring β-Cyclodextrin for DNA Complexation and Delivery by Homogeneous Functionalization at the Secondary Face

(2008) Fernando Ortega-Caballero et al.   ORGANIC LETTERS

Macrocyclic Nonviral Vectors: High Cell Transfection Efficiency and Low Toxicity in a Lower Rim Guanidinium Calix[4]arene

(2008) Valentina Bagnacani et al.   ORGANIC LETTERS

Breaking the Bonds: Non-viral Vectors Become Chemically Dynamic

(2007) Jon A Wolff et al.   MOLECULAR THERAPY