Chromosome Instability Underlies Hematopoietic Stem Cell Dysfunction and Lymphoid Neoplasia Associated with Impaired Fbw7-Mediated Cyclin E Regulation

Fbw7-dependent cyclin E regulation ensures terminal maturation of bone marrow erythroid cells by restraining oxidative metabolism

(2013) Y Xu et al.   ONCOGENE

Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age

(2012) J. Kenyon et al.   BLOOD

An integrated view of cyclin E function and regulation

(2012) Ka Tat Siu et al.   CELL CYCLE

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

(2012) J. E. Grim et al.   MOLECULAR AND CELLULAR BIOLOGY

p57Kip2 and p27Kip1 Cooperate to Maintain Hematopoietic Stem Cell Quiescence through Interactions with Hsc70

(2011) Peng Zou et al.   Cell Stem Cell

p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells

(2011) Akinobu Matsumoto et al.   Cell Stem Cell

Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatasePtpn11(Shp2) on malignant transformation of hematopoietic cells

(2011) Dan Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL)

(2011) Konstantinos J Mavrakis et al.   NATURE GENETICS

Mitotic Catastrophe Occurs in the Absence of Apoptosis in p53-Null Cells with a Defective G1 Checkpoint

(2011) Michalis Fragkos et al.   PLoS One

The Essence of Quiescence

(2011) H. A. Coller   SCIENCE

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

The tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis

(2010) Kuppusamy Balamurugan et al.   EMBO JOURNAL

MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7

(2010) Yanfei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

(2009) M. E. Figueroa et al.   BLOOD

JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal

(2009) Marianne Santaguida et al.   CANCER CELL

p53 Regulates Hematopoietic Stem Cell Quiescence

(2009) Yan Liu et al.   Cell Stem Cell

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family

(2008) Patrick Viatour et al.   Cell Stem Cell

Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

(2008) Jichun Chen et al.   EXPERIMENTAL HEMATOLOGY

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo

(2008) A. C. Minella et al.   GENES & DEVELOPMENT

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

(2008) S. Matsuoka et al.   GENES & DEVELOPMENT

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

(2008) Benjamin J. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS