The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

Aberrant Regulation and Function of MicroRNAs in Cancer

(2014) Brian D. Adams et al.   CURRENT BIOLOGY

A pan-cancer proteomic perspective on The Cancer Genome Atlas

(2014) Rehan Akbani et al.   Nature Communications

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

(2014) Limo Chen et al.   Nature Communications

MiR-200, a new star miRNA in human cancer

(2013) Xiangling Feng et al.   CANCER LETTERS

Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation

(2013) Marco Pieraccioli et al.   CELL CYCLE

Foxf2 in Intestinal Fibroblasts Reduces Numbers of Lgr5+ Stem Cells and Adenoma Formation by Inhibiting Wnt Signaling

(2013) Ali Moussavi Nik et al.   GASTROENTEROLOGY

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

A p21-ZEB1 Complex Inhibits Epithelial-Mesenchymal Transition through the MicroRNA 183-96-182 Cluster

(2013) X. L. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of metastatic progression by microRNA regulatory networks

(2013) Nora Pencheva et al.   NATURE CELL BIOLOGY

Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer

(2013) S S Roy et al.   ONCOGENE

Suppression of MIM by microRNA-182 activates RhoA and promotes breast cancer metastasis

(2013) R Lei et al.   ONCOGENE

Multilayer control of the EMT master regulators

(2013) H Zheng et al.   ONCOGENE

MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer

(2013) Hiroshi Hirata et al.   PLoS One

Decreased FOXF2 mRNA Expression Indicates Early-Onset Metastasis and Poor Prognosis for Breast Cancer Patients with Histological Grade II Tumor

(2013) Peng-Zhou Kong et al.   PLoS One

Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma

(2012) Shyamal Dilhan Weeraratne et al.   ACTA NEUROPATHOLOGICA

Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin

(2012) Junfeng Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Cancer genetics and genomics of human FOX family genes

(2012) Masuko Katoh et al.   CANCER LETTERS

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

(2012) L. A. Byers et al.   CLINICAL CANCER RESEARCH

Cytoplasmic mislocalization of overexpressed FOXF1 is associated with the malignancy and metastasis of colorectal adenocarcinomas

(2012) Pang-Kuo Lo et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma

(2012) Limin Xia et al.   HEPATOLOGY

ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression

(2012) Young-Ho Ahn et al.   JOURNAL OF CLINICAL INVESTIGATION

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of p300 and PCAF in the Control of MicroRNA 200c/141 Transcription and Epithelial Characteristics

(2012) Yoshiaki Mizuguchi et al.   PLoS One

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

ZEB proteins link cell motility with cell cycle control and cell survival in cancer

(2011) Gareth Browne et al.   CELL CYCLE

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice

(2011) Yanan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer

(2011) Xiao-Guang Liu et al.   MEDICAL ONCOLOGY

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

(2011) Emily C. Knouf et al.   NUCLEIC ACIDS RESEARCH

The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis

(2011) Manav Korpal et al.   RNA Biology

Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro

(2010) Yihua Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dysregulated miR-183 inhibits migration in breast cancer cells

(2010) Aoife J Lowery et al.   BMC CANCER

ZEB1-responsive genes in non-small cell lung cancer

(2010) Robert M. Gemmill et al.   CANCER LETTERS

MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

(2010) A. L. Sarver et al.   CANCER RESEARCH

Nuclear Janus-Activated Kinase 2/Nuclear Factor 1-C2 Suppresses Tumorigenesis and Epithelial-to-Mesenchymal Transition by Repressing Forkhead Box F1

(2010) J. Nilsson et al.   CANCER RESEARCH

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Efficient in vivo microRNA targeting of liver metastasis

(2010) C Huynh et al.   ONCOGENE

Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

(2010) Doron Betel et al.   GENOME BIOLOGY

MicroRNAs in Cancer

(2009) Ramiro Garzon et al.   Annual Review of Medicine

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression

(2009) D. L. Gibbons et al.   GENES & DEVELOPMENT

Targeting of Integrin β1 and Kinesin 2α by MicroRNA 183

(2009) Guorong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate Regulation of FOXO1 by miR-27a, miR-96, and miR-182 in Breast Cancer Cells

(2009) Irene K. Guttilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

(2009) Miguel F. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

(2008) S.-M. Park et al.   GENES & DEVELOPMENT

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY