The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression

(2014) Kazunobu Isogaya et al.   CELL RESEARCH

Epithelial Splicing Regulatory Proteins 1 (ESRP1) and 2 (ESRP2) Suppress Cancer Cell Motility via Different Mechanisms

(2014) Hiroki Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing in cancer: implications for biology and therapy

(2014) J Chen et al.   ONCOGENE

The alternative splicing side of cancer

(2014) Giuseppe Biamonti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Arkadia Regulates Tumor Metastasis by Modulation of the TGF-  Pathway

(2013) M. A. Briones-Orta et al.   CANCER RESEARCH

Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas

(2013) Q. Zhao et al.   CLINICAL CANCER RESEARCH

Genomics of alternative splicing: evolution, development and pathophysiology

(2013) Eric R. Gamazon et al.   HUMAN GENETICS

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation

(2013) Y. Erker et al.   MOLECULAR AND CELLULAR BIOLOGY

Heparin-binding epidermal growth factor-like growth factor eliminates constraints on activated Kras to promote rapid onset of pancreatic neoplasia

(2013) K C Ray et al.   ONCOGENE

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

(2013) Z N Zhou et al.   ONCOGENE

Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases

(2013) J Ueda et al.   ONCOGENE

Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing

(2013) Anelia Horvath et al.   Scientific Reports

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Neuropilins: expression and roles in the epithelium

(2012) Jonathan R. L. Wild et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/β-catenin Pathway

(2012) Ren-Jun Hsu et al.   PLoS One

Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT)

(2012) Claude C. Warzecha et al.   SEMINARS IN CANCER BIOLOGY

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Enhancement of TGF-  Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

(2011) V. Sharma et al.   CANCER RESEARCH

TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition

(2011) Takuya Shirakihara et al.   EMBO JOURNAL

The GAS41-PP2Cβ Complex Dephosphorylates p53 at Serine 366 and Regulates Its Stability

(2011) Jeong Hyeon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Type-specific Target Selection by Combinatorial Binding of Smad2/3 Proteins and Hepatocyte Nuclear Factor 4α in HepG2 Cells

(2011) Anna Mizutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical K27-Linked Polyubiquitination of TIEG1 Regulates Foxp3 Expression and Tumor Growth

(2011) D.-J. Peng et al.   JOURNAL OF IMMUNOLOGY

Functional consequences of developmentally regulated alternative splicing

(2011) Auinash Kalsotra et al.   NATURE REVIEWS GENETICS

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP

(2011) K Horiguchi et al.   ONCOGENE

An EMT–Driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype

(2011) Irina M. Shapiro et al.   PLoS Genetics

An ESRP-regulated splicing programme is abrogated during the epithelial–mesenchymal transition

(2010) Claude C Warzecha et al.   EMBO JOURNAL

Arkadia--beyond the TGF-  pathway

(2010) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling

(2010) Anna Mizutani et al.   JOURNAL OF BIOCHEMISTRY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts

(2008) Hisanori Yuzawa et al.   BONE

Transforming Growth Factor-  Suppresses the Ability of Ski to Inhibit Tumor Metastasis by Inducing Its Degradation

(2008) E. Le Scolan et al.   CANCER RESEARCH