Arkadia, a Novel SUMO-Targeted Ubiquitin Ligase Involved in PML Degradation

Sumoylation of MDC1 is important for proper DNA damage response

(2012) Kuntian Luo et al.   EMBO JOURNAL

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

(2012) Y. Yin et al.   GENES & DEVELOPMENT

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair

(2012) Y. Galanty et al.   GENES & DEVELOPMENT

Enhancement of TGF-  Signaling Responses by the E3 Ubiquitin Ligase Arkadia Provides Tumor Suppression in Colorectal Cancer

(2011) V. Sharma et al.   CANCER RESEARCH

Nuclear organization in genome stability: SUMO connections

(2011) Shigeki Nagai et al.   CELL RESEARCH

Purification and identification of endogenous polySUMO conjugates

(2011) Roland Bruderer et al.   EMBO REPORTS

Mechanism of ubiquitylation by dimeric RING ligase RNF4

(2011) Anna Plechanovová et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RING domain dimerization is essential for RNF4 function

(2010) Chu Wai Liew et al.   BIOCHEMICAL JOURNAL

Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling

(2010) Anna Mizutani et al.   JOURNAL OF BIOCHEMISTRY

The SUMO E3 Ligase Activity of Pc2 Is Coordinated through a SUMO Interaction Motif

(2010) S. h. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies

(2010) Marie-Claude Geoffroy et al.   MOLECULAR BIOLOGY OF THE CELL

Genome stability roles of SUMO-targeted ubiquitin ligases

(2009) J. Heideker et al.   DNA REPAIR

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

(2009) Nadine Martin et al.   EMBO JOURNAL

Role of SUMO in RNF4-mediated Promyelocytic Leukemia Protein (PML) Degradation

(2009) Yann Percherancier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An additional role for SUMO in ubiquitin-mediated proteolysis

(2009) Marie-Claude Geoffroy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

System-Wide Changes to SUMO Modifications in Response to Heat Shock

(2009) F. Golebiowski et al.   Science Signaling

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Transforming Growth Factor-  Suppresses the Ability of Ski to Inhibit Tumor Metastasis by Inducing Its Degradation

(2008) E. Le Scolan et al.   CANCER RESEARCH

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

A SIM-ultaneous role for SUMO and ubiquitin

(2008) J. Jefferson P. Perry et al.   TRENDS IN BIOCHEMICAL SCIENCES